2 results match your criteria: "Shaba Medical Center[Affiliation]"
Modeling epithelial-mesenchymal transition in patient-derived breast cancer organoids.
Front Oncol
October 2024
Oncology Institute, Shaba Medical Center, Ramat-Gan, Israel.
Cellular plasticity is enhanced by dedifferentiation processes such as epithelial-mesenchymal transition (EMT). The dynamic and transient nature of EMT-like processes challenges the investigation of cell plasticity in patient-derived breast cancer models. Here, we utilized patient-derived organoids (PDOs) as a model to study the susceptibility of primary breast cancer cells to EMT.
View Article and Find Full Text PDFIntegrase strand transfer inhibitor (INSTI)-resistance mutations for the surveillance of transmitted HIV-1 drug resistance.
J Antimicrob Chemother
January 2020
Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, CA, USA.
Background: Integrase strand transfer inhibitors (INSTIs) are expected to be widely adopted globally, requiring surveillance of resistance emergence and transmission.
Objectives: We therefore sought to develop a standardized list of INSTI-resistance mutations suitable for the surveillance of transmitted INSTI resistance.
Methods: To characterize the suitability of the INSTI-resistance mutations for transmitted HIV-1 drug resistance (TDR) surveillance, we classified them according to their presence on published expert lists, conservation in INSTI-naive persons, frequency in INSTI-treated persons and contribution to reduced in vitro susceptibility.