Unlocking new possibilities in ionic thermoelectric materials: a machine learning perspective.

The high thermopower of ionic thermoelectric (-TE) materials holds promise for miniaturized waste-heat recovery devices and thermal sensors. However, progress is hampered by laborious trial-and-error experimentations, which lack theoretical underpinning. Herein, by introducing the simplified molecular-input line-entry system, we have addressed the challenge posed by the inconsistency of -TE material types, and present a machine learning model that evaluates the Seebeck coefficient with an of 0.

A Wireless Health Monitoring System Accomplishing Bimodal Decoupling Based on an "IS"-Shaped Multifunctional Conductive Hydrogel.

Flexible wearable sensors with bimodal functionality offer substantial value for human health monitoring, as relying on a single indicator is insufficient for capturing comprehensive physiological information. However, bimodal sensors face multiple challenges in practical applications, including mutual interference between various modalities, and integration of excellent mechanical properties, interfacial adhesion, environmental adaptability and biocompatibility. Herein, the multifunctional hydrogel, synthesized through radical grafting and supramolecular self-crosslinking reactions, exhibits excellent thermal sensitivity (TCR = -1.

Psychological stress and depression symptoms in nursing undergraduates: the chain mediating effect of cognitive reappraisal and ruminate thinking.

Background: Nursing students exhibit a higher incidence of mental disorders. Studies have identified psychological stress contributes to elevated depression symptoms through reappraisal cognitive in nursing students. However, there is little research exploring the knowledge regarding the role of ruminative thinking in mediating the associations between psychological stress and depression symptoms.

Using electrical resistivity techniques (ERT and SP) for nondestructive detection of seepage channels at the Leitai heritage site, China.

Seepage accelerates the weathering and destruction of cultural heritage sites, posing a major preservation challenge, while the concealed nature of seepage channels complicates their detection due to noninvasive requirements. In this study, we applied a comprehensive geophysical approach, integrating electrical resistivity tomography (ERT) and self-potential (SP) techniques, to image seepage channels within the Leitai heritage site. These potential seepage channels have already caused a collapse pit measuring 3.

Temperature influence on matric suction in unsaturated soils: experimental insights.

Temperature is a critical factor affecting the matric suction of unsaturated soils. This study employed a simple and time-saving method to investigate the influences of temperature and moisture content on the temperature dependence of matric suction in loess and sand soils. Based on experimental data, the fitting performance of three data-fitting models-Brooks-Corey, van Genuchten, and Fredlund-Xing -was evaluated at temperatures above 0 °C.

Expert consensus on pulpotomy in the management of mature permanent teeth with pulpitis.

Pulpotomy, which belongs to vital pulp therapy, has become a strategy for managing pulpitis in recent decades. This minimally invasive treatment reflects the recognition of preserving healthy dental pulp and optimizing long-term patient-centered outcomes. Pulpotomy is categorized into partial pulpotomy (PP), the removal of a partial segment of the coronal pulp tissue, and full pulpotomy (FP), the removal of whole coronal pulp, which is followed by applying the biomaterials onto the remaining pulp tissue and ultimately restoring the tooth.

Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content.

The anti-PD-1 mAb may be further considered along with PGD2 or active molecules that can promote PGD2 synthesis to enhance the anti-tumor immune response.

A comprehensive investigation of identifying miRNA biomarkers and their potential role in age-related cataract by meta-analysis and bioinformatics analysis.

Purpose: Age-related cataract (ARC) remains one of the leading causes of blindness globally. Despite the satisfactory outcomes of surgical interventions, significant disparities in access to medical care prevent many patients from receiving effective treatment. Thus, identifying reliable biomarkers and therapeutic targets to expand treatment options for ARC is essential.

Association of frailty index with new-onset diabetes: from the China Health and Retirement Longitudinal Study (CHARLS).

Background: To investigate the association of frailty status and its changes with new-onset diabetes.

Methods: A total of 4638 participants from the China Health and Retirement Longitudinal Study (CHARLS) were included. Frailty status was assessed by the frailty index (FI) and categorized as robust, pre-frail, and frail.

Impact of thrombocytopenia on failure of endoscopic variceal treatment in cirrhotic patients with acute variceal bleeding.

Background: Acute variceal bleeding (AVB), a life-threatening complication of liver cirrhosis, can be effectively treated by endoscopy, but there is a risk of early rebleeding after endoscopic variceal treatment (EVT). Thrombocytopenia is the most common hemostatic abnormality in liver cirrhosis. However, it is still unclear about whether thrombocytopenia increases the failure of EVT in cirrhotic patients with AVB.

Tumor burden with AFP improves survival prediction for TACE-treated patients with HCC: An international observational study.

Background & Aims: Current prognostic models for patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) are not extensively validated and widely accepted. We aimed to develop and validate a continuous model incorporating tumor burden and biology for individual survival prediction and risk stratification.

Methods: Overall, 4,377 treatment-naive candidates for whom TACE was recommended, from 39 centers in five countries, were enrolled and divided into training, internal validation, and two external validation datasets.

High-Aspect-Ratio InGaO Integrated with Amorphous AlO Nanofibers: All-Inorganic Self-Supporting Wearable Membranes for Ultralow-Concentration NO Sensing in Simulated Exhalation.

Achieving high flexibility, breathability, and sensitivity in inorganic semiconductor gas sensors remains a substantial challenge, especially for wearable applications in high-humidity environments. This study develops a hyper-flexible, thermally stable, and highly breathable full-inorganic, self-supporting InGaO-AlO/AlO nanofiber membrane sensor, fabricated using a dual-spinneret electrospinning method with an interlocking design. This innovative sensor has a bilayer structure with an amorphous AlO nanofiber substrate layer supporting an active layer of high-aspect-ratio interwoven InGaO and AlO nanofibers, providing outstanding flexibility, elevated breathability, and strong thermal stability.

Electrostatic Harmonization for Superior Charge Extraction at Interface for Stable High-Efficiency FAPbI Quantum Dots Solar Cells.

Organic-inorganic formamidinium lead triiodide (FAPbI) hybrid perovskite quantum dots (QDs) have garnered considerable attention in the photovoltaic field due to their narrow bandgap, exceptional environmental stability, and prolonged carrier lifetime. Unfortunately, their insulating ligands and surface vacancy defects pose significant obstacles to efficient charge transfer across device interfaces. In this work, an electrostatic harmonization strategy at the interface using a donor-acceptor dipole molecular attachment to achieve enhanced charge separation capabilities on the QD surface is ventured.

Multi-Dimensional Color Tunable Long Persistent Luminescence in Metal Halide-Based CPs Through Precise Manipulation of Electronic and Steric Effects.

Regulating strategies for long persistent luminescence (LPL) are always in high demand. Herein, a series of coordination polymers (CPs) (SUST-Z1-Z4) are fabricated using 1,10-phenanthroline derivatives involving different substituents (─H, ─CH, ─Cl, and ─Br) as ligands, respectively. Crystallographic data demonstrate that these CPs adopt alternating arrangements of cadmium halide chains and π-conjugated ligands.

Iodine Stabilization in Perovskite Lattice for Internal Stress Relief.

Atomic iodine ionization in perovskite crystals leads to defect formation, lattice distortion, and the occurrence of localized micro-strain. These atomic-level chemical and mechanical effects significantly alter the electronic band landscape, profoundly affecting device performance. While iodine stabilization effects have traditionally been focused on stability, their impact on electrical properties, particularly the coupling effect with internal stress and lattice strain, remains underexplored.

Positron emission tomography tracers for synucleinopathies.

Synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, are characterized by the aggregation of α-synuclein. Variations in brain distribution allow for differentiation among these diseases and facilitate precise clinical diagnosis. However, distinguishing between synucleinopathies and Parkinsonism with tauopathies poses a challenge, significantly impacting clinical drug development.

A ratiometric fluorescence sensor based on molecular imprinting technology for rapid and visual detection of norfloxacin.

The problem of excessive use and abuse of antibiotics in the environment and food biology is becoming increasingly prominent, and norfloxacin (NOR) is widely used as an inexpensive and broad-spectrum antibiotic drug. Therefore, rapid and effective detection of antibiotics and residues in biological samples has become a demand of the times. This article describes a ratiometric fluorescence sensor based on molecular imprinting technology for the rapid and visual detection of NOR.

Net energy of grains for dairy goats differed with processing methods and grain types.

Background: The diverse types and processing methods of grains intricately influence the sites and digestibility of starch digestion, thereby impacting energy utilization. This study aimed to explore the impact of grain variety and processing methods on the net energy (NE) in dairy goats, analyzing these effects at the level of nutrient digestion and metabolism.

Methods: Eighteen castrated Guanzhong dairy goats (44.

Design and synthesis of a new highly efficient adjustable Ln-MOF for fluorescence sensing and information encryption.

Elemental analysis, infrared spectroscopy, and X-ray single crystal diffraction indicated that a novel metal-organic framework (Tb-MOF) designated as 0.5n[Hbpy]·[Tb(dpa)(HO)]·4nHO was synthesized successfully, (where Hdpa = 5-(3, 4-dicarboxy- phenoxy) isophenic acid, bpy = protonated 4,4'-bipyridine). Tb-MOF adopts a 3D network structure based on Tb ions and the (dpa) ligand through µ: η, η, η, η binding modes.

Melatonin improves endometrial receptivity and embryo implantation via MT2/PI3K/LIF signaling pathway in sows.

Background: Increased backfat thickness of sows in early gestation is negative to reproductive performance. Endometrial receptivity is an important determinant of reproductive success, but it is unclear whether the effect of sow backfat thickness on litter size is associated with endometrial receptivity and whether melatonin treatment may have benefits. The present study seeks to answer these questions through in vitro and in vivo investigations.

Inhibition of METTL14 overcomes CDK4/6 inhibitor resistance driven by METTL14-m6A-E2F1-axis in ERα-positive breast cancer.

CDK4/6i, the first-line drug for treating ERα-positive breast cancer, significantly improves clinical outcomes. However, CDK4/6i resistance often develops and remains a major hurdle, and the underlying mechanisms remain challenging to fully investigate. Here, we used Genome-wide CRISPR/Cas9 library screening combined with single-cell sequencing to screen for molecules mediating CDK4/6i resistance and identified METTL14 as a determinant of CDK4/6i sensitivity.

Systematic functional characterization of non-coding regulatory SNPs associated with central obesity.

Central obesity is associated with higher risk of developing a wide range of diseases independent of overall obesity. Genome-wide association studies (GWASs) have identified more than 300 susceptibility loci associated with central obesity. However, the functional understanding of these loci is limited by the fact that most loci are in non-coding regions.

Arbuscular mycorrhizal fungi mitigate cadmium stress in maize.

Soil cadmium (Cd) pollution poses a significant environmental threat, impacting global food security and human health. Recent studies have highlighted the potential of arbuscular mycorrhizal (AM) fungi to protect crops from various heavy metal stresses, including Cd toxicity. To elucidate the tolerance mechanisms of maize in response to Cd toxicity under AM symbiosis, this study used two maize genotypes with contrasting Cd tolerance: Zhengdan958 (Cd-tolerant) and Zhongke11 (Cd-sensitive).

Smartphone-Assisted Fluorescence Determination of Inorganic Phosphorus Using a Samarium Metal-Organic Framework.

Inorganic phosphori are widely used in food, whose quantitative detection method is of significance. This work presents a Sm-DDB (HDDB = 1,3-di(3',5'-dicarboxylphenyl)benzene), which acts as a ratiometric fluorescence sensor to monitor PO, HPO, and (PO) with high sensitivity. The determination factors of pH, MOF dosage, and fluorescence response time are optimized as 7.

Neohesperidin Improves Depressive-Like Behavior Induced by Chronic Unpredictable Mild Stress in Mice.

Depression is a common and complex neuropsychiatric disorder affecting people of all ages worldwide, associated with high rates of relapse and disability. Neohesperidin (NEO) is a dietary flavonoid with applications in therapeutics; however, its effects on depressive-like behavior remain unknown. Here, we evaluated the effects of NEO on depressive-like behavior induced by chronic and unpredictable mild stress (CUMS).