3 results match your criteria: "Shaanxi Province Blood Center[Affiliation]"

Article Synopsis
  • HLA class II molecules play a key role in acquired aplastic anaemia (AA) by affecting immune responses and T cell-mediated cell death in the bone marrow.
  • A study of 96 AA patients found specific amino acid variations in HLA molecules that are significantly linked to the disease, particularly at certain residue positions in DQB1 and DRB1.
  • Structural analysis suggests that these variations may alter the immune response by changing how antigens are presented to T cells, highlighting potential avenues for new immunotherapy treatments.
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Extracellular Vehicles from Commensal Skin Inhibit Proliferation and Biofilm Formation.

ACS Infect Dis

February 2024

National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 710119, China.

The colonizing microbiota on the body surface play a crucial role in barrier function. () is a significant contributor to skin infection, and the utilization of colonization resistance of skin commensal microorganisms to counteract the invasion of pathogens is a viable approach. However, most studies on colonization resistance have focused on skin bacteria, with limited research on the resistance of skin fungal communities to pathogenic bacteria.

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Background: Occult hepatitis B virus (HBV) infection (OBI) is primarily characterized by the persistence of HBV-DNA in the liver tissues and/or in the serum without detectable HBsAg. Human leukocyte antigen (HLA) polymorphisms have been found to be strongly associated with HBV in different ethnic backgrounds. The association of HLA-DRB1-DQB1 haplotypes with OBI has not been previously reported in China.

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