Synthesis and Biological Activity of New Hydrazones Based on N-Aminomorpholine.

The data on the synthesis of N-aminomorpholine hydrazones are presented. It is shown that the interaction of N-aminomorpholine with functionally substituted benzaldehydes and 4-pyridinaldehyde in isopropyl alcohol leads to the formation of corresponding hydrazones. The structure of the synthesized compounds was studied by H and C NMR spectroscopy methods, including the COSY (H-H), HMQC (H-C) and HMBC (H-C) methodologies.

Morpholine, Piperazine, and Piperidine Derivatives as Antidiabetic Agents.

Diabetes mellitus is a severe endocrine disease that affects more and more people every year. Modern medical chemistry sets itself the task of finding effective and safe drugs against diabetes. This review provides an overview of potential antidiabetic drugs based on three heterocyclic compounds, namely morpholine, piperazine, and piperidine.

Mechanisms of Concept Verbalization in the Ethnolinguistic Context.

This article investigates the verbalization mechanisms of the 'family' concept within the Kazakh, Russian, and English linguistic cultures. The research aims to examine the verbal representation mechanisms of the 'family' concept within the linguistic worldviews of the aforementioned cultures. The research material comprises dictionary definitions of the primary lexemes as presented in explanatory dictionaries and synonym dictionaries, proverbs and sayings, phraseological units, and data derived from an associative experiment.

Explicit and Implicit Ways of Expressing Author's Modality in Kazakh, Kyrgyz and Russian Languages: A Comparative Aspect.

Linguistic modality is one of the most complex categories, that is why its nature, meanings and ways of expression often become the object of various, at times, controversial theories. The present article described the concept of modality in the context of linguistic research. The purpose of this study was to identify the means of expressing author's modality in Kazakh, Kyrgyz and Russian, determine their relations in intra- and inter-system contexts, and specify the significance of modality for typological studies of these languages.

Absorption of Water Vapor by Bambus[6]uril and a Density Functional Theory Study of Its Aqua Complexes.

The absorption/desorption of water vapor by bambus[6]uril (Bu[6]) has been studied. According to kinetic experiments, the absorption capacity of Bu[6] is 4 moles of water per 1 mole of Bu[6] with the absorption duration of 20 min and the complete desorption duration of 100 min. Experimental rate constants for water vapor absorption and desorption by Bu[6] have been determined to be 0.

Inhibition of Acetylcholinesterase by Novel Lupinine Derivatives.

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory loss and cognitive impairment due in part to a severe loss of cholinergic neurons in specific brain areas. AD is the most common type of dementia in the aging population. Although several acetylcholinesterase (AChE) inhibitors are currently available, their performance sometimes yields unexpected results.

Speech therapy to overcome dyslexia in primary schoolers.

This research was aimed to investigate changes in the reading technique and in terms of its semantic charge in primary schoolers diagnosed with dyslexia, which occur as a result of the integrated use of speech therapy techniques. The study was performed between 2016 and 2019 in 6 schools of Moscow and Almaty. It enrolled 194 and 200 children, respectively, who were examined with form I to III inclusive.

Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine.

This article has studied the synthesis of a new derivative of the known alkaloid cytisine contained in the seeds of plants of Cytisus laburnum L. and Thermopsis lanceolata R.Br.

Combined Computational and Experimental Studies of Anabasine Encapsulation by Beta-Cyclodextrin.

The encapsulation of the famous alkaloid, anabasine, with β-CD was studied to obtain a more stable and bioavailable inclusion complex. Various in silico and experimental studies of the obtained β-CD-anabasine complex are presented. Firstly, molecular docking studies were conducted against the α, β, and γ cyclodextrins to explore which subclass is the best for encapsulation.

Isolation and In Silico Inhibitory Potential against SARS-CoV-2 RNA Polymerase of the Rare Kaempferol 3--(6″--acetyl)-Glucoside from .

The phytochemical constituents of Jaub. & Spach (Family Polygonaceae) were studied for the first time. The study resulted in the isolation of the rare flavonol glycoside, kaempferol 3--(6″--acetyl)-glucoside,(K3G-A).

Treatment of waste stabilization pond effluent using natural zeolite for irrigation potential.

Direct utilization of treated effluent from natural treatment systems for irrigation can be challenging on sensitive plants due to high levels of salinity. Post-treatment of such an effluent prior to its applicability in irrigation can be of significant importance. In this study, the wastewater from a natural treatment plant was treated using a lab-scale filtration system with zeolite as a filter material.

Isolation and In Silico SARS-CoV-2 Main Protease Inhibition Potential of Jusan Coumarin, a New Dicoumarin from .

A new dicoumarin, jusan coumarin, (), has been isolated from aerial parts. The chemical structure of jusan coumarin was estimated, by 1D, 2D NMR as well as HR-Ms spectroscopic methods, to be 7-hydroxy-6-methoxy-3-[(2-oxo-2H-chromen-6-yl)oxy]-2H-chromen-2-one. As the first time to be introduced in nature, its potential against SARS-CoV-2 has been estimated using various in silico methods.

Jusanin, a New Flavonoid from with an In Silico Inhibitory Potential against the SARS-CoV-2 Main Protease.

A new flavonoid, Jusanin, () has been isolated from the aerial parts of . The chemical structure of Jusanin has been elucidated using 1D, 2D NMR, and HR-Ms spectroscopic methods to be 5,2',4'-trihydroxy-6,7,5'-trimethoxyflavone. Being new in nature, the inhibition potential of has been estimated against SARS-CoV-2 using different in silico techniques.

Isolation and In Silico Anti-SARS-CoV-2 Papain-Like Protease Potentialities of Two Rare 2-Phenoxychromone Derivatives from spp.

Two rare 2-phenoxychromone derivatives, 6-demethoxy-4`-O-capillarsine () and tenuflorin C (), were isolated from the areal parts of and respectively, for the first time. Being rare in nature, the inhibition potentialities of and against SARS-CoV-2 was investigated using multistage in silico techniques. At first, molecular similarity and fingerprint studies were conducted for and against co-crystallized ligands of eight different COVID-19 enzymes.

Assessing the Influence of Electrode Polarity on the Treatment of Poultry Slaughterhouse Wastewater.

Electrochemical methods have been increasingly gaining popularity in the field of wastewater treatment. However, the performance of these methods can be highly affected by the polarity direction as determined by the electrodes arrangement (anode to cathode or cathode to anode); as well as the characteristics of the wastewater to be treated as determined by the type of wastewater. The presented research work investigated the relationship between polarity direction and the removal of pollutants from poultry slaughterhouse wastewater using titanium and aluminium electrode materials.

Investigating the Influence of Column Depth on the Treatment of Textile Wastewater Using Natural Zeolite.

Textile industry production processes generate one of the most highly polluted wastewaters in the world. Unfortunately, the field is also challenged by the availability of relatively cheap and highly effective technologies for wastewater purification. The application of natural zeolite as a depth filter offers an alternative and potential approach for textile wastewater treatment.