216 results match your criteria: "Servicio de Endocrinología y Nutrición. Complejo Hospitalario Universitario de Albacete.[Affiliation]"

The CDK12-BRCA1 signaling axis mediates dinaciclib-associated radiosensitivity through p53-mediated cellular senescence.

Mol Oncol

December 2024

Laboratorio de Oncología Molecular, Unidad de Medicina Molecular, Instituto de Biomedicina, Universidad de Castilla-La Mancha, Albacete, Spain.

Article Synopsis
  • * In experiments, dinaciclib increased the sensitivity of certain cancer cell lines to radiation but did not significantly affect apoptosis levels or alter certain cellular signaling pathways, suggesting a complex interaction between the drug and radiation.
  • * The study highlights how dinaciclib's inhibition of CDK12 leads to reduced BRCA1 levels, which affects DNA repair mechanisms and may contribute to cancer cell aging, proposing a potential personalized treatment approach based on the genetic characteristics of different tumors.
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Article Synopsis
  • Pulmonary embolism (PE) is a major cause of hospital deaths and cardiovascular issues, with traditional treatments like anticoagulation and surgery being standard options.
  • Recent advancements include catheter-directed interventions (CDI), such as thrombolysis, which may quickly enhance patient outcomes, despite limited supporting evidence from clinical trials.
  • A joint report highlights the need for rapid response teams, thorough patient evaluation, and collaborative methods to optimize treatment and outcomes for those dealing with PE.
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Low penetrance of frequent ATP7B mutations explains the low prevalence of Wilson disease. Lessons from real-life registries.

Dig Liver Dis

September 2024

Grupo de Investigación Patología Médica, Instituto de Investigaciones Biomédicas y Sanitarias. Universidad de Las Palmas de Gran Canaria. Servicio Digestivo, Complejo Hospitalario Universitario Insular Materno Infantil (CHUIMI), Las Palmas de Gran Canaria, Spain. Electronic address:

Article Synopsis
  • Wilson disease is a genetic disorder affecting copper metabolism, primarily linked to mutations in the ATP7B gene, showing a wide range of clinical symptoms among patients.
  • A study of 260 patients revealed that some common mutations, particularly p.Met645Arg and p.Gly869Arg, are underreported due to their milder symptoms, leading to a higher estimated prevalence than recorded (1:3,785, suggesting over 10,500 potential cases in Spain).
  • The findings indicate that individuals with the p.Met645Arg mutation often have fewer severe symptoms at diagnosis and are more likely to be diagnosed later in life, underscoring the need for increased awareness and early intervention.
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Introduction And Objectives: We report the results of the 2023 Spanish catheter ablation registry.

Methods: Procedural data were collected and incorporated into the REDCap platform by all participating centers through a specific form.

Results: There were 104 participating centers in 2023 compared with 103 in 2022.

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Introduction: Currently there is a shortage of general practitioners (GP), and this is expected to increase in the coming years. Despite this need, it is a specialty that is supposedly little demanded, leaving specialized training places unfilled in recent years. The purpose of this study is to present new parameters to more objectively measure the demand and the relationship between supply and demand.

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Undergraduate and postgraduate training in Endocrinology and Nutrition.

Endocrinol Diabetes Nutr (Engl Ed)

January 2024

Servicio de Endocrinología y Nutrición, Complejo Hospitalario Universitario de Albacete, Albacete, Spain; Vocal de docencia y formación 2020-2023, Sociedad Española de Endocrinología y Nutrición. Electronic address:

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Gas cooking indoors and respiratory symptoms in the ECRHS cohort.

Int J Hyg Environ Health

March 2024

National Heart and Lung Institute, Imperial College London, London, UK; MRC Centre for Environment & Health, London, UK. Electronic address:

Background: Gas cooking is an important source of indoor air pollutants, and there is some limited evidence that it might adversely be associated with respiratory health. Using repeated cross-sectional data from the multi-centre international European Community Respiratory Health Survey, we assessed whether adults using gas cookers have increased risk of respiratory symptoms compared to those using electric cookers and tested whether there was effect modification by a priori selected factors.

Methods: Data on respiratory symptoms and gas cooking were collected from participants at 26-55 and 38-67 years (median time between examinations 11.

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Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort.

Int J Infect Dis

December 2023

Department of Infectious Diseases, Microbiology and Parasitology, Institute of Biomedicine of Seville, University Hospital Virgen del Rocío, Spanish National Research Council, University of Seville, Spain; CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP).

Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events.

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Article Synopsis
  • This article reports on the annual activities of the Interventional Cardiology Association of the Spanish Society of Cardiology for 2022.
  • A total of 111 centers participated, revealing a 4.8% increase in diagnostic studies and a significant 22% rise in PCIs on the left main coronary artery, while the overall PCI numbers remained stable.
  • Key trends included a preference for the radial approach in 94.9% of cases, increased use of drug-eluting balloons and intracoronary imaging, and a continuous rise in noncoronary procedures, especially those related to heart valve and structural heart issues.
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Background: While the adverse effects of short-term ambient ozone exposure on lung function are well-documented, the impact of long-term exposure remains poorly understood, especially in adults.

Methods: We aimed to investigate the association between long-term ozone exposure and lung function decline. The 3014 participants were drawn from 17 centers across eight countries, all of which were from the European Community Respiratory Health Survey (ECRHS).

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CYP21A2 and CYP11B1 gene analyses in a virilized newborn female with congenital adrenal hyperplasia.

Med Clin (Barc)

November 2023

Laboratorio de Diagnóstico Molecular, Servicio de Bioquímica, Hospital General Universitario Gregorio Marañón, Madrid, España; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, España. Electronic address:

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Vaccination trends in people with HIV infection participanting in the hospital-based survey of patients infected with HIV, 2006-2021.

Enferm Infecc Microbiol Clin (Engl Ed)

August 2024

Unidad de Vigilancia de VIH, ITS y Hepatitis B y C. Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, Spain; CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.

Objective: To assess the trend in hepatitis A, hepatitis B, pneumococcal, tetanus and seasonal influenza vaccination in people with HIV infection and to analyse associated factors.

Methods: The Hospital Survey of Patients with HIV, an annual cross-sectional study conducted on a fixed day (2006-2021), was used. Inpatients and outpatients were included.

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Introduction: In February 2022, the Emerging Thoracic Surgery Group of the Spanish Society of Pneumology and Thoracic Surgery initiated a multicenter study on the surgical management of primary spontaneous pneumothorax (PSP). As a preliminary step, this survey was developed with the aim of finding out the current situation in our country to specify and direct this project.

Method: A descriptive study was carried out based on the results of this survey launched through the Google Docs® platform.

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Introduction: The prevalence of dysphagia in hospitalized patients is extraordinarily high and little known. The goal of care should be to assess the efficacy and safety of swallowing, to indicate personalized nutritional therapy. The development of Dysphagia Units, as a multidisciplinary team, facilitates comprehensive care for this type of patient.

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Introduction And Objectives: Vaccines against SARS-CoV-2 have been a major scientific and medical achievement in the control of the COVID-19 pandemic. However, very infrequent cases of inflammatory heart disease have been described as adverse events, leading to uncertainty in the scientific community and in the general population.

Methods: The Vaccine-Carditis Registry has included all cases of myocarditis and pericarditis diagnosed within 30 days after COVID-19 vaccination since August 1, 2021 in 29 centers throughout the Spanish territory.

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MAPK11 (p38β) is a major determinant of cellular radiosensitivity by controlling ionizing radiation-associated senescence: An in vitro study.

Clin Transl Radiat Oncol

July 2023

Laboratorio de Oncología Molecular, Unidad de Medicina Molecular, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha. Unidad Asociada de Biomedicina UCLM, Unidad asociada al CSIC, Albacete, España.

Background And Purpose: MAPKs are among the most relevant signalling pathways involved in coordinating cell responses to different stimuli. This group includes p38MAPKs, constituted by 4 different proteins with a high sequence homology: MAPK14 (p38α), MAPK11 (p38β), MAPK12 (p38γ) and MAPK13 (p38δ). Despite their high similarity, each member shows unique expression patterns and even exclusive functions.

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Residential greenspace and lung function decline over 20 years in a prospective cohort: The ECRHS study.

Environ Int

August 2023

Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany; Allergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, Australia. Electronic address:

Article Synopsis
  • The study examines the link between residential greenspace and lung function decline over 20 years in 5,559 adults across 11 countries, revealing conflicting prior research results.
  • It measured lung function at three different ages and assessed greenspace using the Normalized Difference Vegetation Index (NDVI), considering various green space types around residential areas.
  • The findings indicated that increased greenspace, particularly within 500 meters, correlates with a faster decline in lung function, especially in females and individuals in low air pollution areas, challenging the assumption that more greenspace equals better lung health.
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Cardiogenic shock care in centers with an infarction code program but without cardiac surgery.

Rev Esp Cardiol (Engl Ed)

August 2023

Unidad de Hemodinámica, Servicio de Cardiología, Hospital Universitario Clínico San Cecilio, Instituto de Investigación Biosanitaria IBS, Granada, Spain.

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