103 results match your criteria: "Servicio de Dermatología y Venereología del Hospital Clínico Universitario San Cecilio[Affiliation]"

Clinical-Epidemiological Profile, and Treatment Response in Relation to Associated Atopic Comorbidity in Atopic Dermatitis. Experience From the BIOBADATOP Registry.

Actas Dermosifiliogr

November 2024

Servicio de Dermatología, Hospital Universitari Germans Trias i Pujol, Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, España; Departament de Medicina, Universitat Autònoma de Barcelona (UAB), Barcelona, España.

Article Synopsis
  • A study was conducted on patients with atopic dermatitis (AD) to explore the impact of atopic comorbidities like asthma and allergic rhinitis on their treatment response.
  • Data was collected from the BIOBADATOP registry, involving 509 patients, mostly adults with severe AD, and analyzed for associations between atopic comorbidities and clinical characteristics.
  • Results indicated that patients with personal atopic comorbidities had more severe symptoms and a higher history of treatments, but no significant differences in treatment response were found after 6 and 12 months, suggesting a need for longer follow-up.
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Article Synopsis
  • Patch test outcomes can be affected by age, but there are mixed findings on how age impacts these results.
  • The study involved over 13,000 patients and revealed that middle-aged adults (31-65 years) had the highest rates of positive skin sensitisation results, particularly for certain substances like nickel and potassium dichromate.
  • Overall, while age does influence some patch test results, most allergens showed consistent reactivity across ages, underscoring the importance of standard testing regardless of age.
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Article Synopsis
  • * The MEASURE-AD trial was conducted to gather comprehensive data on the burden of AD, using both patient and physician feedback, focusing on adults with moderate-to-severe cases.
  • * Results from the Spanish cohort revealed that patients with higher disease severity (EASI scores 21.1-72) experienced greater symptom burden, mental health issues, reduced quality of life, increased healthcare usage, and higher out-of-pocket costs compared to those with lower severity scores.
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Introduction And Objectives: We report the results of the 2023 Spanish catheter ablation registry.

Methods: Procedural data were collected and incorporated into the REDCap platform by all participating centers through a specific form.

Results: There were 104 participating centers in 2023 compared with 103 in 2022.

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Article Synopsis
  • * In a group of 13 patients who underwent revision surgery after using ceramics, assessments showed that despite appearances of fusion on imaging, actual solid fusion was lacking according to surgical and histological evaluations.
  • * Findings indicated that biphasic ceramics did not integrate well with bone, with evidence of incomplete resorption and replacement by immature tissue, suggesting that their use should be approached with caution.
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A retrospective study describing the acetabular consequences of Legg- Calve-Perthes disease.

BMC Musculoskelet Disord

September 2024

SERGAS (Servizo Galego de Saude), Santiago University Clinical Hospital, Building C, Travesía da Choupana S/N, Santiago de Compostela, 15706, Spain.

Article Synopsis
  • Legg Calve Perthes disease (LCPD) is a childhood hip disorder caused by reduced blood flow, leading to femoral head deformity if not treated.
  • This study investigated four pelvic radiographic parameters to see if they can predict outcomes in LCPD patients, comparing data from healthy vs. affected hips.
  • Significant differences were found in three parameters, but only the Acetabular Depth-Width Ratio was predictive of disease outcomes, highlighting the need for more extensive research.
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The One Health approach, recognizing the interconnectedness of human, animal, and environmental health, has gained significance amid emerging zoonotic diseases and antibiotic resistance concerns. This paper aims to demonstrate the utility of a collaborative tool, the SIEGA, for monitoring infectious diseases across domains, fostering a comprehensive understanding of disease dynamics and risk factors, highlighting the pivotal role of One Health surveillance systems. Raw whole-genome sequencing is processed through different species-specific open software that additionally reports the presence of genes associated to anti-microbial resistances and virulence.

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Detecting the association of genetic variants to the response of biological therapy represents an important advance in developing a personalized therapy. The aim of this work was to study the association of polymorphisms with an optimal response to tildrakizumab in patients with psoriasis in a real-life clinical practice. Ninety patients with plaque psoriasis recruited from-Spanish hospitals receiving tildrakizumab for at least 24 weeks were genotyped for 180 polymorphisms.

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After the meeting held by the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) back in October 2021, changes were suggested to the Spanish Standard Series patch testing. Hydroxyethyl methacrylate (2% pet.), textile dye mixt (6.

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Introduction: A clinical dermatological research was conducted in Spain from 2005 through 2014 as part of the MaIND project with the provinces or centers with the highest number of published articles. However, a low level of evidence in scientific production was confirmed as the overall result. The aim of this study is to update the Spanish clinical dermatological research in bibliometric terms from 2015 through 2021 with comparisons between both periods of time.

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Molecular and phylogenetic characterization of the monkeypox outbreak in the South of Spain.

Health Sci Rep

March 2024

Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), ISCIII Madrid Spain.

Article Synopsis
  • The Monkeypox virus (MPXV), previously limited to Africa, experienced a rapid outbreak in 2022 across non-endemic countries, prompting genomic surveillance in southern Spain.
  • Whole genome sequencing of 160 MPXV samples was conducted, revealing genomic profiles and tracking relationships to prior outbreak sequences.
  • Notably, a mutation linked to potential drug resistance was found in a patient who died, suggesting implications for treatment efficacy, while most samples showed low mutation rates consistent with DNA viruses.
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Clinical practice guideline on the management of vestibular schwannoma.

Acta Otorrinolaringol Esp (Engl Ed)

August 2024

Servicio de Otorrinolaringología, Hospital Universitario La Paz, Madrid, Spain; Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ), Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain.

Article Synopsis
  • - Vestibular schwannoma (VS), the most common tumor in the cerebellopontine angle, often leads to challenging treatment decisions among observation, surgery, or radiotherapy based on patient-specific factors including age and symptoms.
  • - A comprehensive literature review was conducted to create a clinical guide addressing frequently asked questions by clinicians regarding VS, with input from a panel of experts from the SEORL-CCC.
  • - The resulting clinical practice guideline summarizes the 13 most debated topics related to VS management, presenting answers to 50 key questions, though it notes that the levels of evidence are mostly medium or low due to a lack of sufficient prospective studies.
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Background: Although the Spanish Ministry of Health prepares national therapeutic positioning reports (TPRs) and drug reimbursement policies, each of the country's 17 autonomous communities (ACs) is responsible for health care services and prescription requirements in its territory. The aim of the EQUIDAD study was to describe and explore potential differences in prescription requirements for new dermatology drugs across the autonomous communities.

Material And Methods: Cross-sectional study conducted in April and May, 2023.

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To evaluate molecular assays for Mpox diagnosis available in various clinical microbiology services in Spain through a quality control (QC) approach. A total of 14 centers from across Spain participated in the study. The Reference Laboratory dispatched eight serum samples and eight nucleic acid extracts to each participating center.

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Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort.

Int J Infect Dis

December 2023

Department of Infectious Diseases, Microbiology and Parasitology, Institute of Biomedicine of Seville, University Hospital Virgen del Rocío, Spanish National Research Council, University of Seville, Spain; CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP).

Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events.

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Background: Although the Spanish Ministry of Health prepares national therapeutic positioning reports (TPRs) and drug reimbursement policies, each of the country's 17 autonomous communities (ACs) is responsible for health care services and prescription requirements in its territory. The aim of the EQUIDAD study was to describe and explore potential differences in prescription requirements for new dermatology drugs across the autonomous communities.

Material And Methods: Cross-sectional study conducted in April and May, 2023.

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Background: Treatment of splenic trauma is currently based on non-surgical treatment or the use of interventional radiology. The conservative surgery of the spleen in splenic trauma remains marginal.

Objective: To analyze the safety and efficacy of conservative surgical treatment in splenic trauma.

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Ocular involvement in adult and paediatric patients with monogenic autoinflammatory diseases: a Spanish multicentre retrospective study.

Clin Exp Rheumatol

October 2023

Autoinflammatory Diseases Clin Unit & Vasculitis Research Unit, Dept of Autoimmune Diseases, Hosp Clínic Barcelona, Univ of Barcelona, Inst d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Center of the European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA), Spanish Center of the Centros, Servicios y Unidades de Referencia (CSUR) and Catalan Center of the Xarxa d'Unitats d'Expertesa Clínica(XUEC) for Autoinflammatory Diseases, Barcelona, Spain.

Article Synopsis
  • * Among 46 patients, conjunctivitis (56.5%) and uveitis (50%) were the most common eye conditions, with cataracts and posterior synechiae being the primary structural complications.
  • * The findings indicate that this cohort experienced less severe eye involvement compared to previous studies primarily focused on children, with effective treatment leading to good visual outcomes for most patients.
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Introduction: HPV infection is a common risk factor for all anogenital cancers. However, there are important differences in the epidemiology of anogenital cancers and these have not been compared considering diverse epidemiological indicators over a long period of time. To fill this gap, we investigated incidence, mortality, and survival trends of anogenital cancers over a period of three decades.

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Background: Several studies support the hypothesis that scabies is on the rise in Spain. There are also concerns about the possible development of resistance to treatment and an increase in atypical presentations. The aims of this study were to describe the demographic and clinical characteristics of patients with scabies seen by dermatologists in Spain, to identify the possible emergence of atypical forms of scabies, and to explore the frequency of treatment failures and associated risk factors.

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Drug Survival in Cyclosporine Treatment for Moderate to Severe Atopic Dermatitis: Analysis of the Spanish Atopic Dermatitis Registry (BIOBADATOP).

Actas Dermosifiliogr

April 2024

Servicio de Dermatología, Complejo Hospitalario Universitario de Pontevedra, Pontevedra, España; Grupo de Investigación DIPO, Instituto de Investigación Sanitaria Galicia Sur (IIS Galicia Sur), SERGAS-UVIGO, España.

Background: The past 5 years have seen a proliferation of new treatments for atopic dermatitis (AD). We analyzed recent drug survival data for cyclosporine in this setting. Because the Spanish National Healthcare system requires patients with AD to be treated with cyclosporine before they can be prescribed other systemic treatments, drug survival for cyclosporine may be shorter than in other diseases.

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Millions of SARS-CoV-2 whole genome sequences have been generated to date. However, good quality data and adequate surveillance systems are required to contribute to meaningful surveillance in public health. In this context, the network of Spanish laboratories for coronavirus (RELECOV) was created with the main goal of promoting actions to speed up the detection, analyses, and evaluation of SARS-CoV-2 at a national level, partially structured and financed by an ECDC-HERA-Incubator action (ECDC/GRANT/2021/024).

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Impact of nutritional and educational support on home enteral nutrition.

J Health Popul Nutr

May 2023

Departamento de Medicina, Facultad de Medicina, Av. de la Investigación, 11, 18016, Granada, Spain.

Background: Home Enteral Nutrition (HEN) is used to prevent or correct malnutrition in outpatients. Due to the complexity of this process, the indication, follow-up, and results of an educational program of HEN patients was evaluated.

Methods: A prospective, observational, real-life, multicenter study was performed in 21 Spanish Hospital.

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The advent of biosimilar drugs and their use in routine clinical practice has revolutionized the management of moderate to severe psoriasis and led to changes in the positioning of the existing molecules used to control this condition. Evidence from clinical trials complemented by real-world experience has helped to clarify concepts and has significantly changed the use and positioning of biologic agents in this setting. The present document is an update on the position of the Spanish Psoriasis Working Group regarding the use of biosimilar drugs, which takes into account this new situation.

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