Transcriptome analysis reveals differences in developmental neurotoxicity mechanism of methyl-, ethyl-, and propyl- parabens in zebrafish embryos.

Studies on the comparison of developmental (neuro) toxicity of parabens are currently limited, and unharmonized concentrations between phenotypic observations and transcriptome analysis hamper the understanding of their differential molecular mechanisms. Thus, developmental toxicity testing was conducted herein using the commonly used methyl- (MtP), ethyl- (EtP), and propyl-parabens (PrP) in zebrafish embryos. With a benchmark dose of 5%, embryonic-mortality-based point-of-departure (M-POD) values of the three parabens were determined, and changes in locomotor behavior were evaluated at concentrations of 0, M-POD/50, M-POD/10, and M-POD, where transcriptome analysis was conducted to explore the underlying neurotoxicity mechanism.

Size-dependent seizurogenic effect of polystyrene microplastics in zebrafish embryos.

The effects of polystyrene microplastic (PS-MP) size on neurotoxicity remain to be evaluated at various microsizes, and the seizurogenic effects of PS-MPs are unknown. This study aimed to evaluate the swimming behavior of zebrafish larvae under light-dark transitions after exposure to four PS-MP sizes (i.e.

Nano-QTTR development for interspecies aquatic toxicity of silver nanoparticles between daphnia and fish.

Limited studies of quantitative toxicity-toxicity relationship (QTTR) modeling have been conducted to predict interspecies toxicity of engineered nanomaterials (ENMs) between aquatic test species. A meta-analysis of 66 publications providing acute toxicity data of silver nanoparticles (AgNPs) to daphnia and fish was performed, and the toxicity data, physicochemical properties, and experimental conditions were collected and curated. Based on Euclidean distance (ED) grouping, a meaningful correlation of logarithmic lethal concentrations between daphnia and fish was derived for bare (R = 0.

miR-137 and miR-141 regulate tail defects in zebrafish embryos caused by triphenyl phosphate (TPHP).

Exposure to triphenyl phosphate (TPHP), an organophosphate flame retardants (OPFRs), caused developmental toxicity in zebrafish embryos. However, the underlying molecular mechanism at the epigenetic level is largely unknown. Based on developmental toxicity (i.