Effect of mechanical and chemical surface treatments on the repairing of milled and 3D-printed denture bases.

Ensuring a strong bond between chairside autopolymerized acrylic resin to denture base is essential for denture repair and reline procedures. However, there is no established protocol to enhance bond strength between autopolymerizing resin and computer-aided design and computer-aided manufacturing (CAD-CAM) denture base materials. The purpose of this study was to determine shear bond strength of CAD-CAM denture bases and autopolymerizing acrylic resin after mechanical and chemical surface treatments compared with heat-polymerized acrylic resin.

Cost-effectiveness of expanding national health insurance coverage for composite resin restorations in cancer patients in South Korea.

Objectives: Cancer patients often have compromised oral health, making them vulnerable to severe dental caries and restoration failures. Due to the nature of cervical or anterior caries in cancer patients, the use of adequate restorative materials is important. However, public dental insurance coverage for composite treatments varies among countries and only glass ionomer cements (GICs) are covered in all age groups in South Korea.

Application of Collagen Matrix in Peri-Implant Dehiscence Defect: A Case Series.

During implant placement, dehiscence defects can result in complications such as mucosal recession and peri-implantitis. Whereas guided bone regeneration (GBR) is a common approach to managing these defects, it is often complex and time-intensive. This case series evaluates an alternative method using a collagen matrix (Collagen Graft2) applied to peri-implant dehiscence defects without GBR.

A new method to measure the mechanical properties of rotary endodontic Ni-Ti files: Measurement of 6-axis force/torque and automatic root canal preparation.

The purpose of this study was to develop a new instrument to measure the mechanical properties of rotary endodontic Ni-Ti files (ProTaper Gold F2, ProTaper Ultimate F2, and HyFlex EDM Onefile), and to evaluate the overall utility of the device. The instrument was capable of analyzing the 6-axis force/torque generated by the files during cyclic dynamic movement in a metal curved artificial root canal, and doing automatic cyclic dynamic filing in a resin root canal with a preset vertical force limit by adopting a negative feedback mechanism. By analyzing the 6-axis force/torque, we were able to estimate the position and contact points of the files in the curved root canal.

Inhibition of Epithelial-Mesenchymal Transition and Migration in Cisplatin-resistant Cancer Through Combined Treatment With Cisplatin and SH003.

Background/aim: This study investigated the synergistic effects of combining cisplatin and SH003 treatment on the viability, apoptosis, cytotoxicity, migration and epithelial-mesenchymal transition (EMT) in cisplatin-resistant cancer cell lines YD-8/CIS, YD-9/CIS and YD-38/CIS.

Materials And Methods: The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to assess cell viability, while trypan blue exclusion assay was used to evaluate cytotoxicity. Flow cytometry and western blot analysis measured apoptotic cell death.

Lipoteichoic Acid from Lacticaseibacillus rhamnosus GG as a Novel Intracanal Medicament Targeting Enterococcus faecalis Biofilm Formation.

The demand for safe and effective endodontic medicaments to control Enterococcus faecalis biofilms, a contributor to apical periodontitis, is increasing. Recently, lipoteichoic acid (LTA) of family Lactobacillaceae has been shown to have anti-biofilm effects against various oral pathogens. Preliminary experiments showed that LTA purified from Lacticaseibacillus rhamnosus GG (Lgg.

Underlying bone change in oral squamous cell carcinoma observed from magnetic resonance imaging and computed tomography: Potential implications for tumor aggressiveness and prognosis.

Background: In cases where oral squamous cell carcinoma (OSCC) invades the jawbone, clinicians frequently observe abnormal attenuation on computed tomography (CT) and pathologic signal intensity (SI) on magnetic resonance (MR) imaging of the affected underlying bone marrow. This study introduced a concept of "underlying bone change" to examine its association with clinicopathological features and prognosis of OSCC, as well as its correlation with medullary invasion.

Materials And Methods: We enrolled 93 consecutive patients diagnosed with OSCC, who underwent mandibulectomy between 2010 and 2016.

Antiviral Activity of Angelica Tenuissima Nakai against Influenza A Virus.

The influenza A virus poses a serious threat to human health and is an important global public health issue. The drugs currently used for treatment are becoming increasingly ineffective against influenza A viruses and require the development of new antiviral drugs. Angelica tenuissima Nakai (ATN), a traditional herbal medicine belonging to the Umbelliferae family, exhibits a broad range of pharmacological activities, including inflammation, headache, and cold symptoms.

Can deep learning-designed anterior tooth-borne crown fulfill morphologic, aesthetic, and functional criteria in clinical practice?

Objectives: This study aimed to compare the design outcomes of anterior crowns generated using deep learning (DL)-based software with those fabricated by a technician using conventional dental computer-assisted design (CAD) software without DL support, with a focus on the evaluation of crown morphology, function, and aesthetics.

Methods: Twenty-five in vivo datasets comprising maxillary and mandibular arch scans of prepared maxillary central incisors were utilized to design anterior crowns by using three methods: 1) a DL-based method resulting in as-generated outcome (DB), 2) a DL-based method further optimized by a technician (DM), and 3) a conventional CAD-based method (NC, control). Evaluations were conducted for crown morphology (total discrepancy volume (TDV), root mean square (RMS), positive average (PA) and negative average (NA) deviations), functional aspects (incisal path: deviations, length, and mean inclination), and aesthetics (crown width, height, width-to-height ratio, angular radius of mesioincisal line angle, proximal contact length, and tooth axis angle).

Antimicrobial adhesive self-healing hydrogels for efficient dental biofilm removal from periodontal tissue.

Objectives: Oral biofilms, including pathogens such as Porphyromonas gingivalis, are involved in the initiation and progression of various periodontal diseases. However, the treatment of these diseases is hindered by the limited efficacy of many antimicrobial materials in removing biofilms under the harsh conditions of the oral cavity. Our objective is to develop a gel-type antimicrobial agent with optimal physicochemical properties, strong tissue adhesion, prolonged antimicrobial activity, and biocompatibility to serve as an adjunctive treatment for periodontal diseases.

Identification of candidate exposure biomarkers for acetyl tributyl citrate and acetyl triethyl citrate using suspect screening in human liver microsomes.

Acetyl tributyl citrate (ATBC) and acetyl triethyl citrate (ATEC) are increasingly used as alternatives to phthalates in various products, including food packaging, medical devices, and personal care items, raising concerns about their potential health impacts. This study aimed to investigate the in vitro human metabolism of ATBC and ATEC and identify potential exposure biomarkers applicable in human biomonitoring. Pooled human liver microsomes were utilized to conduct in vitro metabolism assays of deuterium labeled ATBC (ATBC-d) and ATEC, and ultra performance liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry (UPLC-qToF/MS) was employed for analysis.

Additive manufacturing trueness and internal fit of crowns in resin modified with a commercially available ceramic composite concentrate.

Statement Of Problem: Inorganic fillers can be incorporated into additively manufactured (AM) resins to improve their properties, and a ceramic composite concentrate has been recently marketed for this purpose. However, knowledge on the printability of AM resins modified with this concentrate is lacking.

Purpose: The purpose of this in vitro study was to evaluate the manufacturing trueness and internal fit of AM crowns in a dental resin modified with a commercially available ceramic composite concentrate.