Limited Reconstructive Options of Jaw Osteomyelitis in the Osteopetrosis Patient Complicated by Blood Dyscrasia.

Osteopetrosis is a rare systemic skeletal disorder characterized by increased bone density and mass resulting from suboptimal or impaired resorption of osteoclastic bone. Compromised bone marrow function and associated disorders of red blood cells contribute to hematopoietic abnormalities, which exacerbate the risk of complex, recurrent infections such as jaw osteomyelitis. This case report describes the treatment of a 68-year-old Korean female with autosomal-dominant osteopetrosis who presented with severe and persistent jaw osteomyelitis complicated by hematopoietic dysregulation.

Anti-inflammatory and osteoconductive multi-functional nanoparticles for the regeneration of an inflamed alveolar bone defect.

Infected alveolar bone defects pose challenging clinical issues due to disrupted intrinsic healing mechanisms. Thus, the employment of advanced biomaterials enabling the modulation of several aspects of bone regeneration is necessary. This study investigated the effect of multi-functional nanoparticles on anti-inflammatory/osteoconductive characteristics and bone repair in the context of inflamed bone abnormalities.

Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian Randomization.

Recent cohort studies suggest a potential association between atopic dermatitis and dementia, though the evidence remains conflicting. This study aims to elucidate the association between atopic dermatitis and dementia employing systematic review, meta-analysis, and Mendelian randomization (MR). A comprehensive search was performed to select eligible cohort studies using Medline, Embase, Scopus, ScienceDirect, and the Web of Science database.

Effect of nanoparticulate CaCO on the biological properties of calcium silicate cement.

This study aimed to evaluate the effects of nanoparticulate CaCO (NPCC) on the biological properties of calcium silicate-based cements (CSCs), including their cytotoxicity, in vitro osteogenic activity, and interactions with rat femur tissue. The average size of NPCC was 90.3±26.

Age-related morphological changes of the pubic symphyseal surface: using three-dimensional statistical shape modeling.

Computational analysis of the pubic symphyseal surface is widely used for accurate age estimation, offering quantitative precision through the detection of subtle morphological changes. However, these methods often lack insights into the underlying morphological changes across different age groups. To bridge this gap, the study utilizes statistical shape modeling (SSM), a versatile tool capable of describing diverse morphological variations within populations.

Protective effects of methylnissolin and methylnissolin-3-O-β-d-glucopyranoside on TNF-α-induced inflammation in human dermal fibroblasts.

Methylnissolin-3-O-β-d-glucopyranoside (MNG) and methylnissolin (MN) are pterocarpan derivatives that are found in plants, such as Astragalus membranaceus. There are limited existing studies on the potential health benefits of MNG, and currently there is no evidence to suggest that MNG has any impact on skin-aging. Tumor necrosis factor-alpha (TNF-α) plays a significant role in skin aging by promoting chronic inflammation, damaging skin cells, and impairing the skin's natural repair mechanisms.

Evaluation of the Mechanical and Biological Properties of Polycaprolactone Scaffolds Produced by a Material Extrusion 3D Printer or 3D Pen: A Novel Bone Repair Strategy.

Addressing the high cost and long cycle associated with the multistep digital restoration process involving 3D printing technology, we proposed the 3D pen as an innovative strategy for rapid bone repair. Capitalizing on the low melting point characteristic of polycaprolactone (PCL), we introduced, for the first time, the novel concept of directly constructing scaffolds at bone defect sites using 3D pens. In this in vitro study, we meticulously evaluated both the mechanical and biological properties of 3D pen-printed PCL scaffolds with six distinct textures: unidirectional (UNI) (0°, 45°, 90°), bidirectional (BID) (-45°/45°, 0°/90°), and concentric (CON).

Inhibition of nitric oxide synthase transforms carotid occlusion-mediated benign oligemia into large cerebral infarction.

It remains unclear why unilateral proximal carotid artery occlusion (UCAO) causes benign oligemia in mice, yet leads to various outcomes (asymptomatic-to-death) in humans. We hypothesized that inhibition of nitric oxide synthase (NOS) both transforms UCAO-mediated oligemia into full infarction and expands pre-existing infarction. Using 900 mice, we i) investigated stroke-related effects of UCAO with/without intraperitoneal administration of the NOS inhibitor (NOSi) N-nitro-L-arginine methyl ester (L-NAME, 400 mg/kg); ii) examined the rescue effect of the NO-donor, molsidomine (200 mg/kg at 30 minutes); and iii) tested the impact of antiplatelet medications.

Artificial intelligence application in endodontics: A narrative review.

Purpose: This review aimed to explore the scientific literature concerning the methodologies and applications of artificial intelligence (AI) in the field of endodontics. The findings may equip dentists with the necessary technical knowledge to understand the opportunities presented by AI.

Materials And Methods: Articles published between 1992 and 2023 were retrieved through an electronic search of Medline via the PubMed, Scopus, and Google Scholar databases.

Pedicle ossification following mandibular reconstruction using fibular free flap in a patient with osteoradionecrosis of the jaw: a case report.

Pedicle ossification is a rare but significant complication following mandibular reconstruction using a fibular free flap (FFF), a technique widely employed in maxillofacial surgery due to its reliable vascularized bone supply and low donor site morbidity. The FFF supports dental implantation and prosthetic rehabilitation, with its vascularized periosteum enhancing osteogenic potential. Despite these advantages, unexpected ossification of the flap's vascular pedicle may occur, potentially mimicking tumor recurrence and causing diagnostic uncertainty.

Long-term clinical study of fixed prosthetic rehabilitation using one-piece narrow-diameter implants: a retrospective study.

Objectives: The objective of this study was to evaluate the long-term clinical outcomes of one-piece narrow-diameter implants (NDIs), with diameters of 2.5 mm and 3.0 mm, and to investigate the factors that affect marginal bone loss (MBL) around these implants.

Current options in jaw and facial reconstructions.

In recent years, many advances have been made in surgical fields of oral and maxillofacial reconstruction, and the variety and complexity of available surgical approaches consider different functionalities of the jaw and the aesthetics of the face. There is no validated or scientifically proven basis for deciding which flap to use for reconstruction, so decisions are often made based on the direct and indirect experiential knowledge of the reconstructive surgeon. Considering the modified ladder, elevator, and pie reconstructive options, their risk and donor morbidity, and their long-term outcomes, the simplest option that will achieve the best long-term outcome in terms of form and function and with the lowest donor morbidity should be chosen for the patient's health and social welfare.

Clinical evaluation of the accuracy of two face scanners with different scanning technologies.

Objectives: This study compared the clinical accuracy of two different stationary face scanners, employing progressive capture and multi-view simultaneous capture scanning technologies.

Methods: Forty dentate volunteers participated in the study. Soft tissue landmarks were marked with a pen on the participants' faces to measure the distances between them.

Enhanced heart sound classification using Mel frequency cepstral coefficients and comparative analysis of single vs. ensemble classifier strategies.

This paper seeks to enhance the performance of Mel Frequency Cepstral Coefficients (MFCCs) for detecting abnormal heart sounds. Heart sounds are first pre-processed to remove noise and then segmented into S1, systole, S2, and diastole intervals, with thirteen MFCCs estimated from each segment, yielding 52 MFCCs per beat. Finally, MFCCs are used for heart sound classification.

Differential Regulatory Effects of Probiotics on Bone Metabolism by the Status of Bone Health and Delivery Route.

Probiotics are known to have favorable effects on human health. Nevertheless, probiotics are not always beneficial and can cause unintended adverse effects such as bacteremia and/or inflammation in immunocompromised patients. In the present study, we investigated the effects of probiotics on the regulation of bone metabolism under different health conditions and delivery routes.

Muramyl dipeptide potentiates lipoteichoic acid-induced nitric oxide production via TLR2/NOD2/PAFR signaling pathways.

Lipoteichoic acid (LTA) and peptidoglycan (PGN) are considered as key virulence factors of , which is a representative sepsis-causing Gram-positive pathogen. However, cooperative effect of LTA and PGN on nitric oxide (NO) production is still unclear despite the pivotal roles of NO in initiation and progression of sepsis. We here evaluated the cooperative effects of LTA (SaLTA) and muramyl dipeptide (MDP), the minimal structure of PGN, on NO production in both a mouse macrophage-like cell line, RAW 264.

Induction of Oral Lichen Planus-like Histopathology in Mice.

Oral lichen planus (OLP) is a chronic T cell-mediated inflammatory mucosal disease of unknown etiology. The lack of suitable animal models has hampered understanding of its etiopathogenesis. This study aimed to clarify the contribution of bacterial infection and zinc deficiency (ZD) in OLP pathogenesis by developing a murine model.

Prognostic value of residual disease (RD) biology and gene expression changes during the neoadjuvant treatment in patients with HER2+ early breast cancer (EBC).

Background: In HER2+ early breast cancer (EBC), we investigated tumor and immune changes during neoadjuvant treatment and their impact on residual disease (RD) biology and prognostic implications across 4 neoadjuvant studies of trastuzumab with or without lapatinib, and with or without chemotherapy: CALGB 40601, PAMELA, NeoALTTO and NSABP B-41.

Patients And Methods: We compared tumor and immune gene expression changes during neoadjuvant treatment and their association with with event-free survival (EFS) by uni- and multivariable Cox regression models in different cohorts and timepoints: 452 RD samples at baseline including 169 with a paired RD, and biomarker changes during neoadjuvant therapy, evaluating model performance via the c-index.

Results: Analysis of 169 paired tumor samples revealed a shift in intrinsic subtype proportions from HER2-Enriched at baseline (50.

De novo interleukin-10 production primed by Lactobacillus sakei CVL-001 amplifies the immunomodulatory abilities of mesenchymal stem cells to alleviate colitis.

Mesenchymal stem cells (MSCs) hold therapeutic promise for treating inflammatory bowel disease (IBD) owing to their immunomodulatory properties. Currently, pre-conditioning strategies with several beneficial agents have been applied to enhance the efficacy of MSCs in treating IBDs. Probiotics are increasingly acknowledged as supplemental therapy for IBD; however, their potential benefits in MSCs-based therapy remain largely unexplored.

Are ultrasound salivary parenchymal lesions more severe in primary Sjögren patients with a longer disease duration? A cross-sectional study.

Objectives: Salivary gland ultrasound (SGUS) has an interest in primary Sjögren's disease (pSD) for diagnosis, but the evolution of parenchymal lesions over time is unknown. The objective of this study was to assess the severity of ultrasound abnormalities in relation to pSD duration from the time of buccal dryness onset.

Methods: In this cross-sectional international multicentre study, patients with pSD according to the 2002 or 2016 ACR/EULAR classification criteria were included.

Severe bilateral subcutaneous emphysema after prophylactic treatment: a case report.

Subcutaneous emphysema is the accumulation of gas or air in loose subcutaneous connective tissue. The use of air-driven handpieces in dental procedures is a common iatrogenic cause of intraoral mucogingival barrier disruption by high-pressure air. This case report describes a 60-year-old woman who underwent prophylactic periodontal treatment with an air-abrasive device and subsequently developed severe bilateral subcutaneous emphysema, extending from the temporal region to the thoracic and mediastinal spaces.

Impact of Subjective Masticatory Difficulty on Malnutrition and Frailty in Community-Dwelling Older Adults.

Objectives: This study evaluated the impact of masticatory difficulty on the development and progression of malnutrition, frailty, sarcopenia, and disability in community-dwelling adults, using data from the Korean Frailty and Aging Cohort Study.

Methods: Participants were categorised by presence of masticatory difficulty. The Fried frailty phenotype, mini-nutritional assessments, and diagnostic criteria proposed by Asian Working Group on Sarcopenia were adopted to diagnose frailty, malnutrition, and sarcopenia respectively.

Performance and durability of additively and subtractively manufactured resin-based onlay restorations after thermomechanical aging.

Purpose: To evaluate the effect of material type on dimensional stability, occlusal surface wear, fracture resistance, and failure behavior of resin-based onlay restorations.

Material And Methods: A mandibular right first molar typodont was prepared and digitized using an intraoral scanner to virtually design an onlay restoration with the minimum occlusal thickness of 1.5 mm.