3 results match your criteria: "Seoul National University College of Medicine and Seoul National University Children's Hospital[Affiliation]"
Clinical Characteristics and Etiology of Community-acquired Pneumonia in US Children, 2015-2018.
Pediatr Infect Dis J
May 2022
From the Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Background: Pneumonia has a major impact on childhood health and health care costs. This study was designed to obtain contemporary information on the clinical characteristics and etiology of community-acquired pneumonia (CAP) in children from both inpatient and outpatient settings in the USA.
Methods: We conducted a prospective, multicenter, observational study of CAP among previously healthy children 2 months to 18 years of age in 6 children's hospitals in Ohio from 2015 to 2018.
New susceptible locus, rs9428555, is associated with pediatric-onset immunoglobulin A nephropathy and immunoglobulin A vasculitis in Koreans.
Genes Genomics
September 2021
Department of Pediatrics, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon-Si, Gyeonggi-do, Republic of Korea.
Background: Immunoglobulin A nephropathy (IgAN) is one of the most common primary forms of glomerulonephritis, while IgA vasculitis (IgAV) is the most common systemic vasculitis in children.
Objective: Herein we aimed to uncover single nucleotide polymorphism (SNP) markers associated with these two related diseases by applying association tests and Sanger sequencing.
Methods: Within the discovery stage, genomic DNA in blood samples from 101 enrolled patients were genotyped by the Korean Biobank Array.
Article Synopsis
- Immunoglobulin A nephropathy (IgAN) is a prevalent kidney condition in children and adolescents, and this study analyzed its clinical features and outcomes over the past 30 years in a sample of 1,154 patients in Korea.
- Of the patients studied, 5.6% progressed to severe chronic kidney disease (CKD), with a 10-year CKD-free survival rate of 91.2% and a 20-year rate of 75.6%, showing no significant differences based on diagnosis date.
- The analysis indicated that symptoms like hematuria and proteinuria at diagnosis and lower renal function increased the risk of CKD progression, emphasizing the need for more proactive treatment in cases of pediatric IgAN. *