46 results match your criteria: "Seoul National University 1[Affiliation]"

High-resolution genetic map and SNP chip for molecular breeding in a tetraploid medicinal plant.

Hortic Res

December 2024

Department of Agriculture, Forestry and Bioresources, Plant Genomics and Breeding Institute, College of Agriculture & Life Sciences, Seoul National University 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.

Ginseng () renowned as the king of medicinal plants. Ginseng grows slowly under shade conditions, requiring at least 4 years to produce a limited number of seeds. Molecular breeding of ginseng faces challenges due to its the tetraploid genome and the absence of an efficient molecular marker system.

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Sesquiterpenoids and hexanorcucurbitacin from agarwood with anti-inflammatory effects by inhibiting the STAT1/AKT/MAPK/NLRP3 pathway.

RSC Adv

March 2024

Department of Integrative Biological Sciences and Industry & Convergence Research Center for Natural Products, Sejong University 209, Neungdong-ro, Gwangjin-gu Seoul 05006 Republic of Korea +82-02-3408-4336 +82-02-3408-1959.

Seven unknown compounds 1-7, including four sesquiterpenoids, one azulene-type, one indene-type, and one rare hexanorcucurbitacin, together with eleven knowns ones (8-16), were isolated from the agarwood chips of . The structures of the isolated compounds were elucidated by extensive spectroscopic methods such as mass spectrometry, UV, IR, NMR spectroscopy. The precise stereo-chemical configurations of new compounds were determined by calculated ECD spectra data, as well as a single-crystal X-ray diffraction analysis.

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In light of the pressing need for practical materials and molecular solutions to renewable energy and health problems, to name just two examples, one wonders how to accelerate research and development in the chemical sciences, so as to address the time it takes to bring materials from initial discovery to commercialization. Artificial intelligence (AI)-based techniques, in particular, are having a transformative and accelerating impact on many if not most, technological domains. To shed light on these questions, the authors and participants gathered in person for the ASLLA Symposium on the theme of 'Accelerated Chemical Science with AI' at Gangneung, Republic of Korea.

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While advances in computational techniques have accelerated virtual materials design, the actual synthesis of predicted candidate materials is still an expensive and slow process. While a few initial studies attempted to predict the synthesis routes for inorganic crystals, the existing models do not yield the priority of predictions and could produce thermodynamically unrealistic precursor chemicals. Here, we propose an element-wise graph neural network to predict inorganic synthesis recipes.

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Suppression of the redox reaction between the IGZO surface and the reducing agent TMA using fluorine oxidizing agent treatment.

RSC Adv

November 2023

Department of Electrical and Computer Engineering, Inter-University Semiconductor Research Center, Seoul National University 1 Gwanak-ro, Gwanak-gu Seoul 08826 Republic of Korea

We propose that the post-deposition oxidation of the IGZO surface is essential for improving the interface quality, with AlO prepared by atomic layer deposition (ALD) employing a common metal precursor trimethylaluminum (TMA). Here, the ALD-AlO process was conducted using HO as an oxidant at a substrate temperature of 150 °C after IGZO deposition. The depth-resolved X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM) data reveal the defect-rich and poor interface of the standard AlO/IGZO stack due to the redox reaction between the IGZO surface and TMA.

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Formaldehyde is a toxic compound present in both the environment and living systems, and its detection is important due to its association with various pathological process. In this study, we report a new electrochemiluminescence (ECL) probe based on a cyclometalated iridium complex (IrHAA) for the selective detection of formaldehyde. The homoallylamine moiety in IrHAA reacts with formaldehyde, undergoing a 2-aza-Cope-rearrangement reaction to form a formyl group.

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Article Synopsis
  • A novel dual mechanism for the indolyl 1,3-heteroatom transposition (IHT) of hydroxyindole derivatives has been identified, indicating that two mechanisms work together in this process.
  • Research shows that the efficiency and energy barriers of these pathways depend on the electronic properties of the substrate used.
  • A new strategy has been developed for efficiently adding heteroatoms to the 3-position of indole, with a wide range of substrates and the ability to introduce both oxygen- and nitrogen-based functional groups.
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The development and utilization of biodegradable plastics is an effective way to overcome environmental pollution caused by the disposal of non-degradable plastics. Recently, polybutylene succinate co-butylene adipate co-ethylene succinate co-ethylene adipate, (PBEAS) a biodegradable polymer with excellent strength and elongation, was developed to replace conventional nylon-based non-degradable fishing nets. The biodegradable fishing gear developed in this way can greatly contribute to inhibiting ghost fishing that may occur at the fishing site.

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Cholesterol is essential for neuronal activity and function. Cholesterol depletion in the plasma membrane impairs synaptic transmission. However, the molecular mechanisms by which cholesterol deficiency leads to defects in vesicle fusion remain poorly understood.

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Uneven allocation of resources creates frustration, tension, and conflicts. Confronted with an apparent mismatch between the number of donor atoms and the number of metal atoms to be supported, helically twisted ligands cleverly come up with a sustainable symbiotic solution. As an example, we present a tricopper metallohelicate exhibiting screw motions for intramolecular site exchange.

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Molecular emitters simultaneously generating light at different wavelengths have wide applications. With a small molecule, however, it is challenging to realize two independent radiative pathways. We invented the first examples of dual-emissive single-benzene fluorophores (SBFs).

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Effect of N doping on the microstructure and dry etch properties of amorphous carbon deposited with a DC sputtering system.

RSC Adv

January 2023

Department of Materials Science & Engineering, Seoul National University 1, Gwanak-ro Gwanak-gu Seoul 08826 Republic of Korea +82-2-883-8197 +82-2-880-8986.

The importance of developing a hardmask with excellent performance, and physical and chemical properties to utilize in long-term etching is spotlighted due to the acceleration of development in high-density semiconductors. To develop such a hardmask, amorphous carbon hardmasks doped with various concentrations of N were fabricated with a DC magnetron sputtering system using varying inert gas (Ar to N) ratios. In contrast to the expectation that doped nitrogen would block the permeation of fluorine and improve the etch resistance, as the nitrogen concentration increased, the selectivity of the doped amorphous carbon films decreased.

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Since adenosine monophosphate (AMP) is closely related to many diseases, the measurement of AMP is important for the diagnosis and treatment of related diseases. Among the AMP sensors reported thus far, sensors that selectively recognize AMP, not ADP or ATP, are rare, and complex experimental procedures and additional instruments are required for AMP recognition. We developed a colorimetric chemosensor using calix[6]triazolium (CT6) and intended to use it for the simple and rapid detection of AMP.

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Photoresponsive, switchable, pressure-sensitive adhesives: influence of UV intensity and hydrocarbon chain length of low molecular weight azobenzene compounds.

RSC Adv

November 2021

Laboratory of Adhesion and Bio-Composites, Program in Environmental Materials Science, Department of Agriculture, Forestry and Bioresources, Seoul National University 1 Gwanak-ro, Gwanak-gu Seoul 08826 Republic of Korea

Unlike traditional adhesives with a fixed adhesive force, switchable adhesives, which have an adhesive force that can be adjusted by external stimuli, are specifically designed to be released according to user demand, or to enable the transfer of fine electronic devices. Previously developed switchable adhesives have limitations such as a slow switching rate, narrow adhesion modulation range, or the lack of reusability. Thus, we fabricated switchable pressure-sensitive adhesives (PSAs) that can overcome these limitations.

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Here, we report iron-catalyzed one-pot synthesis of quinoxalines transfer hydrogenative condensation of 2-nitroanilines with vicinal diols. The tricarbonyl (η4-cyclopentadienone) iron complex, which is well known as the Knölker complex, catalyzed the oxidation of alcohols and the reduction of nitroarenes, and the corresponding carbonyl and 1,2-diaminobenzene intermediates were generated . Trimethylamine N-oxide was used to activate the iron complex.

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Recently, reduced TiO nanotube arrays electrochemical self-doping (r-TiO) are emerging as a good alternative to conventional dimensionally stable anodes (DSAs) due to their comparable performance and low-cost. However, compared with conventional DSAs, they suffer from poor stability, low current efficiency, and high energy consumption. Therefore, this study aims to advance the electrochemical performances in the chlorine evolution of r-TiO with a thin RuO layer coating on the nanotube structure (RuO@r-TiO).

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Accurate identification and monitoring of fine dust are emerging as a primary global issue for addressing the harmful effects of fine dust on public health. Identifying the source of fine dust is indispensable for ensuring the human lifespan as well as preventing environmental disasters. Here a simple yet effective spark-induced plasma spectroscopy (SIPS) unit combined with deep learning for real-time classification is verified as a fast and precise PM (particulate matter) source identification technique.

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This study aimed to investigate the age- and sex-specific risk of urogenital infections in patients with type 2 diabetes mellitus (T2DM) treated with sodium-glucose co-transporter 2 (SGLT2) inhibitors. A self-controlled case series was conducted using annual national patient sample datasets from 2016 and 2017. Patients who were treated with SGLT2 inhibitors and who received antimicrobials for urogenital infections were included in the study.

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Metabolic mechanisms of a drug revealed by distortion-free C tracer analysis.

Chem Sci

February 2021

Natural Product Research Institute, College of Pharmacy, Seoul National University 1 Gwanak-ro, Gwanak-gu Seoul 08826 Korea

Metabolomic isotopic tracing can provide flux information useful for understanding drug mechanisms. For that, NMR has the unique advantage of giving positional isotope enrichment information, but the current C 1D NMR approach suffers from low sensitivity and high overlaps. We developed a new 2D heteronuclear NMR experiment incorporating -scaling and distortion-free elements that allows for quantitative analysis of multiplets with high sensitivity and resolution.

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Hydrogen bonding-assisted polarization is an effective strategy to promote bond-making and bond-breaking chemical reactions. Taking inspiration from the catalytic triad of serine protease active sites, we have devised a conformationally well-defined benzimidazole platform that can be systematically functionalized to install multiple hydrogen bonding donor (HBD) and acceptor (HBA) pairs in a serial fashion. We found that an increasing number of interdependent and mutually reinforcing HBD-HBA contacts facilitate the bond-forming reaction of a fluorescence-quenching aldehyde group with the cyanide ion, while suppressing the undesired Brønsted acid-base reaction.

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A mechanistically unique functionalization strategy for a benzylic C(sp)-H bond has been developed based on the facile oxidation event of indole substrates. This novel pathway was initiated by efficient radical generation at the benzylic position of the substrate, with subsequent transition metal catalysis to complete the overall transformation. Ultimately, an aryl or an acyl group could be effectively delivered from an aryl (pseudo)halide or an acid anhydride coupling partner, respectively.

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Predicting the chemical reactivity of organic materials using a machine-learning approach.

Chem Sci

July 2020

Research Institute of Advanced Materials (RIAM), Department of Materials Science and Engineering, Seoul National University 1 Gwanak-ro, Gwanak-gu Seoul 151-742 Republic of Korea

Stability and compatibility between chemical components are essential parameters that need to be considered in the selection of functional materials in configuring a system. In configuring devices such as batteries or solar cells, not only the functionality of individual constituting materials such as electrodes or electrolyte but also an appropriate combination of materials which do not undergo unwanted side reactions is critical in ensuring their reliable performance in long-term operation. While the universal theory that can predict the general chemical reactivity between materials is long awaited and has been the subject of studies with a rich history, traditional ways proposed to date have been mostly based on simple electronic properties of materials such as electronegativity, ionization energy, electron affinity and hardness/softness, and could be applied to only a small group of materials.

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With small molecules, it is not easy to create large void spaces. Flat aromatics stack tightly, while flexible chains fold to fill the cavities. As an intuitive design to make open channels inside molecularly constructed solids, we employed propeller-shaped bicyclic triazoles to prepare a series of aromatic-rich three-dimensional (3D) building blocks.

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Recent research has built a consensus that the binder plays a key role in the performance of high-capacity silicon anodes in lithium-ion batteries. These anodes necessitate the use of a binder to maintain the electrode integrity during the immense volume change of silicon during cycling. Here, Zn-imidazole coordination crosslinks that are formed to carboxymethyl cellulose backbones in situ during electrode fabrication are reported.

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Mild-acid Zn-MnO batteries have been considered a promising alternative to Li-ion batteries for large scale energy storage systems because of their high safety. There have been remarkable improvements in the electrochemical performance of Zn-MnO batteries, although the reaction mechanism of the MnO cathode is not fully understood and still remains controversial. Herein, the reversible dissolution/deposition (Mn/Mn) mechanism of the MnO cathode through a 2e reaction is directly evidenced using solution-based analyses, including electron spin resonance spectroscopy and the designed electrochemical experiments.

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