7,809 results match your criteria: "Seminoma"
[Case of Testicular Seminoma in Which the Diagnosis Was Preceded by the Discovery of Atypically Shaped Metastatic Nodules in the Lung].
Gan To Kagaku Ryoho
September 2024
Dept. of Respirology, Ina Central Hospital.
Article Synopsis
- A 57-year-old man came to the hospital after abnormal findings on a chest X-ray, which led to further imaging revealing solid nodules in his lung.
- Surgery (lobectomy) was done to remove the lung nodule, which was identified as seminoma, a type of testicular cancer.
- A PET-CT scan indicated high metabolic activity in the lung nodules and slight activity in the left testicle, but no tumor was found on ultrasound, leading to a rare diagnosis of testicular seminoma with single lung metastasis.
Article Synopsis
- Testicular germ cell tumours (TGCT) are the most common cancers found in young men, including seminoma and non-seminoma types.
- This study uses whole genome sequencing to analyze adult TGCTs, providing a detailed genomic profile that includes mutations, structural variations, and DNA amplifications.
- The research uncovers correlations between genetic changes and the different growth patterns of TGCT subtypes, highlighting late genomic duplication in some cases and a common immune disruption mechanism in seminomas.
Salmonella bovismorbificans abscess masking a primary testicular tumour in the retroperitoneum - A case report.
Int J Surg Case Rep
December 2024
Department of Surgery and Critical Care, Royal Darwin Hospital, 105 Rocklands Drive, Tiwi, Northern Territory 0810, Australia.
Article Synopsis
- * The patient initially showed symptoms of possible kidney infection, leading to the discovery of a large retroperitoneal mass via CT scan, alongside salmonella detected in his blood cultures.
- * Despite treatment with antibiotics, the abscess did not shrink, prompting further testing that identified both ongoing salmonella infection and the presence of a yolk sac tumor, emphasizing the need to consider underlying cancer when treatment for abscesses is ineffective.
Primary retroperitoneal lymph node dissection in stage II testicular seminoma: a systematic review.
BJU Int
February 2025
EJ Whitten Prostate Cancer Research Centre, Epworth Healthcare, Melbourne, Australia.
Article Synopsis
- The study aimed to systematically review the role of primary retroperitoneal lymph node dissection (RPLND) in stage II testicular seminoma, analyzing its oncological, functional, and peri-operative outcomes based on existing literature up to November 2023.
- Six studies encompassing 385 patients were reviewed, revealing a median operation time of 187 minutes, a median blood loss of 150 mL, and a typical hospital stay of 4 days, with a complication rate of 6.1% for serious issues.
- While long-term survival data is limited, one study showed a 92% 5-year overall survival for treated stage IIA/B disease, indicating that R
[Stage-dependent treatment of seminomas].
Urologie
December 2024
Klinik für Urologie, Uro-Onkologie, spezielle urologische und Roboter-assistierte Chirurgie, Uniklinik Köln, Kerpenerstr. 62, 50937, Köln, Deutschland.
Article Synopsis
- * Seminomas are sensitive to radiation, making it a treatment option for early stages, though there's caution due to potential increased risk of secondary cancers.
- * For nonmetastasized stages, active surveillance is preferred to avoid unnecessary treatment, with nerve-sparing surgery considered in low metastasis cases; guidelines vary between the AUA/NCCN and EAU on this approach.
Article Synopsis
- The study investigates the occurrence of rete hyperplasia and hyaline globules in germ cell tumors, with a focus on their potential to mimic yolk sac tumors, noting a significant misdiagnosis risk over the years.
- Out of 348 evaluated orchiectomies, 30% showed rete hyperplasia and/or hyaline globules, often without any yolk sac tumor component, suggesting a complexity in tumor classifications.
- The findings highlight the importance of accurately identifying these histological features, as they may indicate underlying testicular obstruction due to the tumor, which is crucial for proper treatment decisions.
Cancer risk and legalisation of access to cannabis in the USA: overview of the evidence.
Lancet Public Health
February 2025
Surveillance and Health Equity Science, American Cancer Society, Atlanta, GA, USA.
Article Synopsis
- Cannabis in the USA is moving from being illegal to being more accepted for medical and recreational use, which raises the need for updated information on its potential cancer risks.* -
- Current evidence suggests a link between cannabis use and certain cancers, particularly non-seminoma testicular cancer, but overall, these connections are not yet definitive.* -
- More rigorous research is necessary to better understand the health risks associated with cannabis use, as current limitations in studies hinder informed decision-making by policymakers and healthcare professionals.*
Improved diagnostic confidence using Super Resolution CEUS imaging in testicular lesions.
Clin Hemorheol Microcirc
November 2024
Department of Radiology, Ludwig-Maximilians-University Munich, Munich, Germany.
Article Synopsis
- * Conventional ultrasound is essential for evaluating scrotal conditions, while Contrast-Enhanced Ultrasound (CEUS) helps differentiate between benign and malignant masses.
- * New advancements like Super Resolution CEUS Micro-Vascular Imaging and Time of Arrival mapping enhance the clarity of microvascular structures and improve diagnostic accuracy in testicular pathologies.
Comparison of clinical characteristics of testicular tumor between children and adult population: a retrospective analysis.
BMC Cancer
October 2024
Department of Urology, Anhui Provincial Children's Hospital, Children's Hospital of Fudan University (Affiliated Anhui Branch), No. 39 Wangjing East Road, Hefei, 230000, Anhui Province, People's Republic of China.
Article Synopsis
- - The study aimed to compare clinical and histological differences between testicular tumors (TT) in children and adults by analyzing data from two hospitals over a ten-year span, from 2014 to 2024.
- - A total of 195 patients were analyzed, with 135 children (mean age 2.32 years) and 60 adults (mean age 34.08 years), revealing a higher incidence of TT in younger children and different tumor types predominating in each age group.
- - The most common initial symptom in both children and adults was a painless scrotal mass, and significant differences were found in tumor characteristics based on age, size, and histological type.
Dysgerminomas: germ cell tumors exhibit high expression of PD-L1 and associated with high TILs and good prognosis.
Sci Rep
October 2024
Department of Medical Oncology, King Fahad Specialist Hospital, Eastern Health Cluster, Dammam, Saudi Arabia.
Article Synopsis
- - Ovarian germ cell tumors (OVGCTs) represent 28% of ovarian cancers in Saudi Arabia, with malignant types having a 13% diagnosis rate; patients with recurrent tumors often face a grim prognosis due to aggressive characteristics.
- - This study uniquely investigates PD-L1 expression in OVGCTs, analyzing samples from 34 tumors to understand its role in the tumor microenvironment, immune cell presence, and cancer stem cells' relation to overall clinical outcomes.
- - Results show that dysgerminomas have higher PD-L1 levels than yolk sac tumors, correlating with greater immune cell infiltration and better prognoses, contributing to the potential for immunotherapy in ovarian cancer treatment.
Successful Neoadjuvant Chemotherapy and Surgical Removal of a Nonmetastatic Testicular Round Cell Tumor in a Solomon Island Eclectus Parrot ().
J Avian Med Surg
October 2024
Medical Center for Birds, Oakley, CA 94561, USA.
An intracoelomic mass was palpated on an annual exam of a 24-year-old male Solomon Island eclectus parrot (). The initial diagnostic workup included a complete blood count, plasma biochemistry panel, and coelomic ultrasound. Computed tomography was highly suggestive of a testicular mass.
View Article and Find Full Text PDFPost-pubertal management of undescended testes from the malignancy risk point of view: a systematic review.
F1000Res
November 2024
Department of Urology, Rumah Sakit Dr Cipto Mangunkusumo, University of Indonesia, Central Jakarta, Jakarta, 10430, Indonesia.
Background: Undescended testes (UDT) is a condition where one or both testes is absent in the scrotum. The general age recommendation in which the treatment should be performed is before 18 months old due to the infertility risk and malignancy in later life. In post-pubertal UDT, the current guideline recommends orchiectomy; however, the strength rating of this recommendation is weak.
View Article and Find Full Text PDFCisplatin‑resistant germ cell tumor models: An exploration of the epithelial‑mesenchymal transition regulator .
Mol Med Rep
December 2024
Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo 14784400, Brazil.
Germ cell tumors (GCTs) constitute diverse neoplasms arising in the gonads or extragonadal locations. Testicular GCTs (TGCTs) are the predominant solid tumors in adolescents and young men. Despite cisplatin serving as the primary therapeutic intervention for TGCTs, 10‑20% of patients with advanced disease demonstrate resistance to cisplatin‑based chemotherapy, and epithelial‑mesenchymal transition (EMT) is a potential contributor to this resistance.
View Article and Find Full Text PDFGerm Cell Tumors in 46, XY Gonadal Dysgenesis.
Indian J Endocrinol Metab
June 2023
Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India.
Introduction: To present the clinical data, investigative profile, management, and follow-up of patients with 46, XY gonadal dysgenesis with germ cell tumors from the endocrine unit of a tertiary care university hospital.
Materials And Methods: This retrospective study included 3 cases of 46, XY gonadal dysgenesis with germ cell tumors evaluated and managed at the Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, over a period of 13 years from (September 2008 to December 2021).
Results: Over a period of 13 years, we diagnosed and managed 7 patients with 46, XY gonadal dysgenesis.
Synchronous Seminoma of Testis and Renal Cell Carcinoma: A Rare Case Report.
Medicina (Kaunas)
September 2024
Department of Genetics and Molecular Medicine, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Article Synopsis
- * A 36-year-old patient had both tumors, leading to the removal of a large testicular mass and subsequent surgeries for kidney and adrenal tumors, ultimately diagnosed through histological evaluations.
- * After initial treatment with chemotherapy, the patient experienced progressive metastasis, prompting targeted therapy, indicating a genetic predisposition to having multiple primary tumors, which could be better understood through DNA sequencing.
Expression of Heat Shock Protein 90 in Testicular Cancer: A Retrospective Cohort Study.
Rev Recent Clin Trials
September 2024
Laboratory of Histology and Embryology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Article Synopsis
- The study investigates the role of HSP90 as a potential diagnostic marker and therapeutic target in different types of testicular cancer, particularly focusing on embryonal carcinoma.
- Researchers analyzed HSP90 expression in 84 nonmetastatic testicular cancer patients who underwent surgery, revealing varying positivity rates across tumor types.
- The findings indicate a significant correlation between HSP90 expression in tumors and surrounding normal tissue, emphasizing its potential relevance in understanding and treating testicular cancer.
Seminoma characterized by thickening of the pituitary stalk A case report.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
June 2024
Department of Endocrinology, First Affiliated Hospital of Army Medical University, Chongqing 400038.
Article Synopsis
- Intracranial seminoma is a rare type of cancer that starts in special cells in the brain, often found in the pineal or pituitary gland.
- A 20-year-old patient had headaches and vision problems and was diagnosed with this cancer after an MRI showed issues with his pituitary stalk.
- He had surgery to remove the tumor and received treatment, but it came back a year later, leading to another surgery and ongoing treatments, although he still faces some health challenges.
First Indicator of Relapse in Testicular Cancer and Implications for Follow-up: Analysis of the Swiss Austrian German Testicular Cancer Cohort Study (SAG TCCS).
Eur Urol Open Sci
October 2024
Department of Medical Oncology and Haematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
Article Synopsis
- The study focuses on improving follow-up care for patients with testicular cancer to detect relapses early by analyzing different imaging methods used for relapse detection in a large cohort of patients (1175 enrolled) from the Swiss Austrian German Testicular Cancer Cohort Study.
- Key findings included that 76% of analyzed patients had stage I disease, with a high 5-year relapse-free survival rate of 90.1%. Cross-sectional imaging of the abdomen was found to be the most effective method for detecting relapses, especially abdominal CT scans.
- The researchers proposed updated follow-up schedules emphasizing abdominal imaging while reducing reliance on chest X-rays, aiming to guide clinicians in future patient management strategies.
Pure intertubular seminoma (PITS) of the testis: A multi-institutional cohort of a rare growth pattern of seminoma.
Hum Pathol
November 2024
Department of Pathology and Laboratory Medicine, CORE Diagnostics, India. Electronic address:
Article Synopsis
- Pure intertubular seminoma (PITS) is a rare type of testicular cancer where seminoma cells are found in testicular interstitium without forming a noticeable mass or diffuse growth, leading to challenges in diagnosis.
- This condition often goes unnoticed and is usually diagnosed incidentally during evaluations for testicular pain, infertility, or other issues, with only a minority of cases presenting with metastasis.
- A study involving 15 patients revealed that the average age at presentation was 29, and common symptoms included undescended testis, testicular pain, and infertility, while most patients had normal serum markers and no visible tumors at the time of diagnosis.
Testicular seminoma presenting as an acute strangulated hernia: An intraoperative diagnosis.
Radiol Case Rep
November 2024
Department of Urology, Uro-oncology Section, Hamad Medical Corporation, Doha, Qatar.
Testicular seminomas are the most common type of testicular tumor; atypical presentations can make diagnosis more challenging, leading to delayed treatment. Here, we present a 40-year-old previously healthy male who presented to the emergency department with severe right-sided scrotal swelling and pain. He had a diagnosed but untreated inguinal hernia.
View Article and Find Full Text PDFBilateral testicular seminoma in a captive Siberian chipmunk (Tamias sibiricus).
Top Companion Anim Med
December 2024
Clinical Diagnostic Laboratory, Department of Veterinary Clinical Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Article Synopsis
- - A 5-year-old male Siberian chipmunk had an enlarged left testicle, leading to a diagnosis that considered various types of testicular tumors or inflammation.
- - Upon conducting a fine needle aspiration, doctors found it to be a seminoma and proceeded with a bilateral orchiectomy (removal of both testicles).
- - The chipmunk recovered well post-surgery, and a check-up two years later showed no signs of illness, indicating that surgery can lead to a long-term disease-free outcome in chipmunks.
Association between glutathione S-transferases M1 expression and treatment outcome in germ cell tumor patients.
Neoplasma
August 2024
Department of Pathology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Article Synopsis
- * A study involving 207 newly diagnosed GCT patients linked higher expression levels of GSTM1 to poorer treatment outcomes, particularly in terms of relapse-free survival, especially in tumor types like seminoma and choriocarcinoma.
- * The findings indicate that GSTM1 levels are a potential indicator of treatment resistance in GCTs and may help predict patient outcomes independently of other established risk factors.
Preliminary Evidence of the Possible Roles of the Ferritinophagy-Iron Uptake Axis in Canine Testicular Cancer.
Animals (Basel)
September 2024
Department of Biology, University of Naples 'Federico II', Via Vicinale Cupa Cinthia 21, 80216 Napoli, Italy.
Iron is a key element in spermatogenesis; its metabolic pathway in the testis is strictly regulated. Alterations in iron metabolism are linked to various diseases, including cancer, and changes in iron metabolism-related proteins have been observed in multiple human, mouse and canine tumors. There is limited knowledge about iron metabolism in canine non-neoplastic and neoplastic testes.
View Article and Find Full Text PDFEleven-Year Experience With Midline Extraperitoneal Retroperitoneal Lymph Node Dissection for Germ Cell Tumors.
J Urol
January 2025
Department of Urology, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Purpose: A midline extraperitoneal approach for retroperitoneal lymph node dissection (EP-RPLND) has been associated with decreased morbidity compared to the transperitoneal approach. We aimed to review our 11-year experience in patients with germ cell tumors (GCTs) who underwent EP-RPLND at a single institution.
Materials And Methods: All patients with GCT who underwent EP-RPLND between 2010 and 2021 were reviewed.
[Primary retroperitoneal lymph node dissection in testicular germ cell cancer in clinical stage IIA/B-renaissance of an established treatment?].
Urologie
November 2024
Klinik für Urologie, Uro-Onkologie, roboter-assistierte und spezielle urologische Chirurgie, Uniklinik Köln, Kerpener Str. 62, 50927, Köln, Deutschland.
Background: The guideline-recommended treatment of choice for clinical stage IIA/B testicular germ cell tumors is chemotherapy with three cycles of PEB/four cycles of PE or, alternatively, radiation for seminomas. Despite their high curative efficacy, both options are associated with significant long-term toxicities. We evaluated the functional and oncological outcomes of primary retroperitoneal lymph node dissection (RPLND) as a therapeutic alternative.
View Article and Find Full Text PDF