5,834 results match your criteria: "Seizure Disorders in Pregnancy"
Neurol India
November 2024
Kerala Registry of Epilepsy and Pregnancy Study Group, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.
Background: Cerebral vascular malformations are rare but important causes of epilepsy in young women. The risk of bleed during pregnancy and delivery as well as the fetal outcomes are important concerns for women with epilepsy (WWE) due to cerebral vascular malformations (EVM).
Objectives: We compared the maternal and fetal outcomes of a cohort of EVM with women with focal epilepsy due to other causes (ENVM).
Front Immunol
December 2024
Department of Pathology, NYU Grossman School of Medicine, New York, NY, United States.
Introduction: Involved in immunity and reproduction, natural killer (NK) cells offer opportunities to develop new immunotherapies to treat infections and cancer or to alleviate pregnancy complications. Most current strategies use cytokines or antibodies to enhance NK-cell function, but none use ion channel modulators, which are widely used in clinical practice to treat hypertension, diabetes, epilepsy, and other conditions. Little is known about ion channels in NK cells.
View Article and Find Full Text PDFJ Infect
December 2024
Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland; Department of Paediatrics, The University of Melbourne, Parkville, Australia; Infectious Diseases Research Group, Murdoch Children's Research Institute, Parkville, Australia; Department of Paediatrics, Fribourg Hospital HFR, Fribourg, Switzerland. Electronic address:
Background: Antibiotics are the most commonly prescribed drugs during pregnancy. The long-term health risks to children associated with prenatal antibiotic exposure is unclear.
Objective: To identify the association between prenatal antibiotics and adverse long-term health outcomes in children.
Epilepsy Behav
December 2024
Department of Obstetrics and Gynecology, McGill University Health Centre, Montréal, Quebec, Canada. Electronic address:
Cureus
November 2024
Neurology, Park Hospital, Gurgaon, IND.
We report a primigravida 31-year-old female patient hospitalized at 32 gestational weeks with status epilepticus. In due course of illness, she developed refractory status epilepticus managed with induced coma with propofol and emergency early lower section caesarean surgery (LSCS). A battery of initial laboratory and radiological tests did not lead to a definite diagnosis.
View Article and Find Full Text PDFToxicol Appl Pharmacol
December 2024
Key laboratory of Microecology-immune Regulatory Network and Related Diseases School of Basic Medicine, Jiamusi University, Jiamusi, Heilongjiang Province 154000, PR China. Electronic address:
Cenobamate (CNB) is a novel anti-seizure medication with significant efficacy in treating epilepsy. However, in clinical trials, the most common adverse reactions observed in patients are central nervous system (CNS) symptoms. In animal studies, administration of CNB during pregnancy or lactation has been associated with adverse effects on neurodevelopment in offspring.
View Article and Find Full Text PDFIntroduction: Preeclampsia is associated with acute neurological complications during pregnancy, but the subsequent risk of developing a neurological disorder is unclear. We determined if preeclampsia was associated with the long-term risk of neurological morbidity.
Methods: We conducted a longitudinal cohort study of 1,460,098 pregnant women with and without preeclampsia in Quebec, Canada, between 1989 and 2023.
Epilepsy Behav
December 2024
Neurology Department, Kasr Alainy, Faculty of Medicine, Cairo University, Egypt.
Background & Objectives: Postpartum depression is a debilitating mental health condition that consequently can negatively impact the mother/infant unit. This study aimed to screen for postpartum depression among women with epilepsy (WWE) versus healthy women and its consequences on establishing a proper mother-infant bonding.
Methods: A group of WWE (n = 102) and a control group of healthy women (n = 119) were evaluated 4-6 weeks postpartum.
Neurogenetics
November 2024
Department of Neurology, Children's Hospital of Hebei Province, Shijiazhuang, China.
Background: Leigh syndrome is a common mitochondrial disorder caused by gene mutations in the nucleus and mitochondria. When building mitochondrial complex I, the main subunit ND1 combines with the Q module to form a 273 kDa complex, which then adds Ndufa3, Ndufa8, and Ndufa13 to create an intermediate product of about 283 kDa called Q/Pp-a. Although Ndufa8 and Ndufa13 have been linked to mitochondrial diseases, the role of Ndufa3 in disease development is still not fully understood.
View Article and Find Full Text PDFTransl Pediatr
November 2024
Department of Pediatrics, Second Affiliated Hospital of the Army Medical University, Chongqing, China.
Background: Observational studies on the association between gestational diabetes mellitus (GDM) during pregnancy and pediatric neurological disorders (PNDs) such as cerebral palsy (CP), autism spectrum disorders (ASD), and epilepsy (EP) in offspring have yielded mixed findings, creating ambiguity in causal interpretations. The direct link between GDM and these PNDs remains unclear. Elucidating this connection is vital for developing effective early intervention strategies during pregnancy to mitigate the risk of PNDs in the offspring.
View Article and Find Full Text PDFJ Womens Health (Larchmt)
December 2024
Department of Obstetrics and Gynecology, Stanford University, Stanford, California, USA.
Epilepsy Res
November 2024
Institute of Systems, Molecular and Integrative Biology (ISMIB), University of Liverpool, Liverpool, UK. Electronic address:
Rev Prat
November 2024
Unité d'épilepsie et de réhabilitation neurologique, hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France. Centre de recherche de l'Institut du cerveau et de la moëlle épinière (ICM), UPMC-UMR 7225 CNRS-UMRS 975 Inserm, Paris, France. Université Paris Sorbonne, France.
Epilepsy Behav
November 2024
Boston University Chobanian and Avedesian School of Medicine, Boston, MA, United States; Division of Pediatric Neurology, Boston Medical Center, Boston, MA, United States.
Purpose: Anti-seizure medications (ASM) can lower the efficacy of hormonal birth control (BC), while estrogen-containing BC can increase ASM metabolism, altering seizure frequency. Despite these adverse interactions, many youth with epilepsy demonstrate inadequate knowledge about this topic. Thus, there is a need to develop tools that empower youth with epilepsy to make more informed contraceptive decisions.
View Article and Find Full Text PDFEur J Obstet Gynecol Reprod Biol
January 2025
Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark; Research Unit of Clinical Epidemiology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark. Electronic address:
Purpose: Today about 12.5% of all children are conceived using assisted reproductive technology. Intracytoplasmic sperm injection (ICSI) was introduced without knowledge of the possible long-term adverse consequences on the offspring health.
View Article and Find Full Text PDFFront Pharmacol
November 2024
College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
JAMA Neurol
November 2024
University of Pittsburgh, Pittsburgh, Pennsylvania.
Seizure
December 2024
Department of Neurology and Clinical Neurophysiology, St. Olav University Hospital, Trondheim, Norway; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Purpose: To explore various aspects of pregnancy planning in women with epilepsy and to identify factors needing particular attention in the counselling of these patients with focus on epilepsy type.
Methods: 285 pregnancies in 192 women were collected from the EURAP registry in Trondheim, Norway. Medical records were reviewed to validate diagnoses and types of epilepsy according to revised ILAE classifications.
Nat Commun
November 2024
A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.
The teratogenic potential of valproate in pregnancy is well established; however, evidence regarding the long-term safety of other antiseizure medications (ASMs) during pregnancy remains limited. Using routinely collected primary care data from the UK and nationwide Swedish registries to create a cohort of 3,182,773 children, of which 17,495 were exposed to ASMs in pregnancy, we show that those exposed to valproate were more likely to receive a diagnosis of autism, intellectual disability, and ADHD, when compared to children not exposed to ASMs. Additionally, children exposed to topiramate were 2.
View Article and Find Full Text PDFEpilepsia
November 2024
Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Epilepsia
November 2024
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
This report is the first comprehensive update on the activities of existing epilepsy-pregnancy registries since 2010. The primary aim of these registries, which were initiated by independent international research groups some 25 years ago, has been to assess the risk of major congenital malformations (MCMs) in offspring exposed in utero to different antiseizure medications (ASMs). Progress reports are provided here from the five original registries (the International Registry of Antiepileptic Drugs and Pregnancy EURAP, the North American Antiepileptic Drug Pregnancy Registry, the UK and Ireland Epilepsy and Pregnancy Register, the Kerala Registry of Epilepsy and Pregnancy, and the Raoul Wallenberg Australian Pregnancy Register of Antiepileptic Drugs) plus the more recently initiated West China Registry.
View Article and Find Full Text PDFEpilepsy Curr
October 2024
Johns Hopkins Medicine.
Epilepsy Curr
October 2024
Department of Neurology, Stanford University.
PLoS One
November 2024
Faculty of Medicine, Department of Brain and Neurosciences, Division of Child Neurology, Tottori University, Yonago, Japan.
The relationship between maternal prenatal psychological distress and epilepsy development in offspring has not yet been clarified. Herein, we used a dataset obtained from the Japan Environment and Children's Study, a nationwide birth cohort study, to evaluate the association between six-item Kessler Psychological Distress Scale (K6) scores and epilepsy among 1-3 years old. The data of 97,484 children were retrospectively analyzed.
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