A large-scale clinicopathological and long-term follow-up study of solid papillary carcinoma of the breast.

Solid papillary carcinoma of the breast (SPC) is a rare tumor of the breast with the unique histology and frequent neuroendocrine differentiation. However, a real nature and diagnostic importance of the neuroendocrine differentiation have not been properly handled. And relationship between SPC and the other types of invasive breast carcinoma, especially neuroendocrine tumor of the breast (NETb), has not been fully explained.

Incidence and risk factors of acute encephalopathy with biphasic seizures in febrile status epilepticus.

Objective: To clarify the incidence and risk factors of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) in pediatric patients with febrile status epilepticus (FSE).

Methods: We retrospectively surveyed patients with FSE (≥20 min and ≥40 min) who were younger than 6 years by mailing a questionnaire to 1123 hospitals in Japan. The survey period was 2 years.

Genetic and phenotypic analysis of 101 patients with developmental delay or intellectual disability using whole-exome sequencing.

Whole-exome sequencing (WES) enables identification of pathogenic variants, including copy number variants (CNVs). In this study, we performed WES in 101 Japanese patients with unexplained developmental delay (DD) or intellectual disability (ID) (63 males and 38 females), 98 of them with trio-WES. Pathogenic variants were identified in 54 cases (53.

A case of insulinoma effectively treated with low-dose diazoxide.

Diazoxide is a benzothiadiazine that can be effective in managing hypoglycemia in frail patients with surgical risk. We report here a case of insulinoma effectively treated with diazoxide, as our report will be helpful for similar cases.

Glucocorticoid Receptor Antagonist Administration Prevents Adrenal Gland Atrophy in an ACTH-Independent Cushing's Syndrome Rat Model.

ACTH-independent Cushing's syndrome (CS) is mainly caused by cortisol-secreting adrenocortical tumours. It is well known that secondary adrenal insufficiency occurs after surgical resection of these tumours. In this regard, impaired adrenocortical function is likely induced by atrophy of the residual adrenal tissue as a result of chronic suppression by the low ACTH levels of the hypercortisolism state.

Targeted use of prednisolone with the second IVIG dose for refractory Kawasaki disease.

Background: Prednisolone (PSL) has been suggested to be useful for the treatment of Kawasaki disease (KD) resistant to i.v. immunoglobulin (IVIG), but much remains to be elucidated regarding its use.

Mucinous cystadenocarcinoma of the urachus associated with pseudomyxoma peritonei with emphasis on MR findings.

Urachal mucinous cystadenocarcinoma associated with pseudomyxoma peritonei is extremely rare; only 11 cases are reported. We describe the characteristic imaging findings of this disorder and correlate imaging features by computed tomography, magnetic resonance imaging, and ultrasonography with operative findings and histopathologic specimens.

Inflammatory myofibroblastic tumor in the mediastinum mimicking a malignant tumor.

Inflammatory myofibroblastic tumor (IMT), also called "inflammatory pseudotumor", is a rare benign tumor composed of spindle cells with a variable infiltrate of inflammatory cells and fibrous tissue. There have been many reported cases of IMT in every organ system; however, IMT in the mediastinum is rare. We report a rare, proven case of spontaneous regression of IMT in the right cardiophrenic angle.

MR findings of pseudoneoplastic lesions in the uterine cervix mimicking adenoma malignum.

Pseudoneoplastic glandular lesions are benign lesions that are often histologically and radiographically confused with adenoma malignum, which is a rare variant of mucinous adenocarcinoma of the uterine cervix. 15 cases of pseudoneoplastic glandular lesions, characterized by multilocular cystic masses in the uterine cervix, were investigated; these lesions included endocervical glandular hyperplasia, deep nabothian cysts and tunnel cluster. All lesions were proven by conization or hysterectomy.

[Brain abscess induced by Bacillus licheniformis complications in acute myeloid leukemia (AML)].

A 64-year-old woman with acute myeloid leukemia, headache, vomiting, and fever exceeding 38.5 degrees C on day 15 during severe neutropenia while undergoing second consolidation chemotherapy presented the next day, with an altered mental state. A space-occupying lesion with ring enhancement was detected in her right frontal lobe on CT, indicting a brain abscess.

Magnetic resonance findings of clear-cell adenocarcinofibroma of the ovary.

We report the magnetic resonance (MR) findings of clear-cell adenocarcinofibroma of the ovary. A huge multilocular cystic tumor with solid components was seen in the lower abdominal and pelvic cavity. Thickened cyst wall had low intensity on T2-weighted images, which suggested abundant fibrous tissue.

Analysis of five cases of splanchnic artery aneurysm associated with coeliac artery stenosis due to compression by the median arcuate ligament.

Aim: To elucidate the mechanism of occurrence of splanchnic artery aneurysm associated with coeliac artery stenosis due to compression by the median arcuate ligament, and also to discuss the management for this relatively rare condition.

Materials And Methods: Five consecutive cases of splanchnic artery aneurysm associated with coeliac axis stenosis due to compression by the median arcuate ligament, including four cases of pancreaticoduodenal artery aneurysm and one case of epiploic artery aneurysm, were investigated. These cases were collected over a 5-year period in our local and affiliated hospitals.

[Therapy-related acute promyelocytic leukemia with a t(9;22)(q34;q11) and t(15;17)(q22;q11 to approximately 12) subclone].

The translocation (15;17) is a typical marker of acute promyelocytic leukemia, whereas t(9;22) is predominantly associated with chronic myelogenous leukemia, and seldom with acute myelogenous leukemia. Furthermore, the association between t(15;17) and t(9;22) in the same cell is extremely rare. We present a case of therapy-related acute promyelocytic leukemia (t-APL) with a subclone accompanied by karyotype 46, XX, t(9; 22)(q34;q11), t(15 ;17)(q22;11 to approximately 12) at onset.

[Experience with transurethral uretero-nephrolithotripsy using flexible nephro-ureteroscope].

Disintegration of urinary stones by electrohydraulic lithotripsy (EHL) under transurethral flexible nephro-ureteroscopy was performed for 39 renal and ureteral stones in 38 patients. The use of a ureteral guide tube facilitated the endoscopic manipulation and allowed the endoscope to access the stones in all cases except for two with a severe ureteral stricture. Thirty-seven of the 39 stones (94.