47 results match your criteria: "Seibo International Catholic Hospital[Affiliation]"

Article Synopsis
  • Palmoplantar pustulosis (PPP) is a chronic skin condition causing non-infectious pustules on the palms and soles, and brodalumab, an anti-interleukin-17 monoclonal antibody, is being studied as a potential treatment.
  • A phase 3 trial in Japan involved patients aged 18-70 with moderate to severe PPP, assessing the safety and effectiveness of brodalumab compared to a placebo over 16 weeks.
  • Results showed significant improvement in disease scores for those receiving brodalumab, with a greater reduction in symptoms compared to the placebo, indicating its potential as an effective therapy for PPP.
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Introduction: Palmoplantar pustulosis (PPP) is a pruritic, painful, chronic dermatitis that greatly impacts functioning and quality of life and can be difficult to treat. Approved treatment options for PPP are limited, and many patients do not fully respond to current treatments.

Methods: This was a randomized, double-blind, placebo-controlled, phase 2 study in Japanese patients with moderate to severe PPP and inadequate response to topical treatment.

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Article Synopsis
  • The term pustulotic arthro-osteitis (PAO) was introduced by Sonozaki et al. in 1979, with specific diagnostic criteria established in 1981 that have been widely used for over 40 years.
  • Recent efforts have focused on improving patients' quality of life with PAO through early diagnosis and therapy aimed at achieving clinical, structural, and functional remission.
  • The article translates the 'Modified PAO Diagnostic Guidance 2022', created by Japan's Ministry of Health and relevant organizations, to aid both Japanese and international rheumatology communities.
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Article Synopsis
  • The objective of the revision was to update the 2017 clinical practice guidelines (CPG) for managing microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) in light of new advancements.
  • The revised guidelines were developed using the Grading of Recommendations, Assessment, Development, and Evaluation system, with modifications to four existing clinical questions and the addition of six new ones.
  • Key treatment recommendations include using glucocorticoid with either cyclophosphamide or rituximab for initial therapy, favoring avacopan over high-dose glucocorticoid, and advising against plasma exchange in severe cases, while suggesting glucocorticoid with rituximab over
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Article Synopsis
  • The Japanese Association of Family Physicians Trainees, part of the Japan Primary Care Association, supports residents by providing knowledge, networking opportunities, and international perspectives for their careers since 2017.
  • The publication of a letter seeking support may prevent crucial information from reaching residents who truly need it, especially young physicians not affiliated with JPCA.
  • It's important to clarify the current challenges faced by Japanese residents and encourage collaboration among different organizations to better support them.
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Background: Palmoplantar pustulosis (PPP) is a pruritic, painful, recurrent, and chronic dermatitis with limited therapeutic options.

Objective: To evaluate the efficacy and safety of apremilast for the treatment of Japanese patients with PPP and inadequate response to topical treatment.

Methods: This phase 2, randomized, double-blind, placebo-controlled study enrolled patients with Palmoplantar Pustulosis Area and Severity Index (PPPASI) total score ≥ 12 and moderate or severe pustules/vesicles on the palm or sole (PPPASI pustule/vesicle severity score ≥ 2) at screening and baseline with an inadequate response to topical treatment.

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Article Synopsis
  • It’s uncertain if social participation has led to better social support.
  • A study looked into whether being socially active actually improves social support.
  • The findings suggest that more types of social participation improve social support, especially when people join groups regularly.
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Objectives: Evaluate the experiences and perceptions of patients participating in a simulated clinical trial and identify ways to enhance future patient-centric trial designs.

Design: International, multicentre, non-interventional, virtual clinical trial visits with patient debriefs and advisory boards.

Setting: Virtual clinic visits and accompanying advisory boards.

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Frequency of social participation by types and functional decline: A six-year longitudinal study.

Arch Gerontol Geriatr

September 2023

Center for Preventive Medical Sciences, Chiba University, Inage-ku, Chiba, Japan; Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.

Article Synopsis
  • Social participation helps prevent functional decline in older adults, but the relationship between the frequency and type of participation hasn't been thoroughly studied.
  • Researchers analyzed data from 51,968 Japanese individuals aged 65 and older, focusing on six types of social activities: sports, hobbies, volunteering, neighborhood involvement, senior clubs, and industry groups, over a six-year period.
  • Results indicated that engaging in sports and hobbies at least once or twice a month, or more frequently, reduces the risk of functional decline, highlighting the need for tailored public health strategies that promote specific types and frequencies of social activities for older adults.
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Social participation and incident disability and mortality among frail older adults: A JAGES longitudinal study.

J Am Geriatr Soc

June 2023

Department of Social Preventive Medical Sciences, Center for Preventive Medical Sciences, Chiba University, Chiba, Japan.

Background: Frailty is the highest risk factor for incident disability and mortality. Social participation is a modifiable factor for reducing adverse outcomes among independent older adults. However, the association between social participation and incident disability and mortality among frail older adults remains unclear.

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Article Synopsis
  • - The letter discussed an online workshop focused on social determinants of health (SDH) for family medicine residents and physicians in Japan.
  • - Participants gained both knowledge and reflective skills, as they shared their experiences during the workshop.
  • - The text emphasizes the need for more learning opportunities regarding SDH for family physicians in Japan to improve their practices.
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Article Synopsis
  • Psoriasis negatively affects patients' quality of life and is linked to sleep issues, yet there's limited research on how interleukin-17 blockage therapies like brodalumab influence sleep.
  • A study involving 73 Japanese patients with plaque psoriasis assessed the effectiveness of brodalumab by measuring sleep problems using the Medical Outcomes Study Sleep Scale at various points during treatment.
  • Results showed no significant improvement in overall sleep issues after 12 weeks of brodalumab treatment, highlighting the need for more focus on sleep problems in psoriasis management.
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Article Synopsis
  • * A study assessed the impact of brodalumab on HRQoL in Japanese psoriasis patients, showing significant improvements in quality of life measures after 48 weeks of treatment.
  • * Despite these improvements, some patients still reported persistent itching, which may hinder complete HRQoL recovery, highlighting a gap even with effective treatment.
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Article Synopsis
  • - The 2021 ARDS Clinical Practice Guideline expands on the previous edition by including 15 clinical questions (CQs) for children along with 46 for adults, using systematic review methods and the GRADE system to determine recommendations.
  • - Key recommendations for adult ARDS patients include limiting tidal volume during mechanical ventilation, avoiding excessive targeting of SpO2/PaO2, and recommending low-dose steroids, while also advising against certain diagnostic tools and high-dose steroids.
  • - Pediatric ARDS recommendations include suggesting prone positioning for moderate cases and caution against using non-invasive respiratory support and inhalation therapy, emphasizing a tailored approach to treatment based on the latest evidence.
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Article Synopsis
  • The ARDS Clinical Practice Guideline 2021 is a collaborative effort by Japanese medical societies to update the previous guidelines for managing Acute Respiratory Distress Syndrome (ARDS), now including recommendations for both adults and children.
  • The new guideline expands on the 2016 version by introducing a total of 61 clinical questions (CQs), which were investigated using systematic reviews and meta-analyses to determine recommendations based on evidence.
  • Key recommendations include avoiding certain diagnostic practices for pneumonia in adults, suggesting specific ventilation strategies, and advocating for low-dose steroids, while also providing tailored advice for pediatric patients regarding positioning and the use of respiratory support.
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Article Synopsis
  • * Researchers collected saliva samples from 64 pregnant women at various stages, measuring viral DNA load to assess the presence of HHV-6 and HHV-7 using techniques like qPCR and nested PCR.
  • * Results showed an increase in viral DNA load as pregnancy progressed, particularly around delivery, and a notable connection between lower viral loads and higher abnormal scores on the Edinburgh Postnatal Depression Scale (EPDS), suggesting a potential relationship between viral activity and mental health in these women.
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Synovitis-Acne-Pustulosis-Hyperostosis-Osteitis (SAPHO) syndrome is a rare inflammatory osteoarticular disorder, which encompassed many diseases, including pustulotic arthro-osteitis (PAO). Musculoskeletal manifestations, including osteitis, synovitis, and hyperostosis, are the hallmarks of the SAPHO syndrome and affect a variety of regions of the body. Recent survey indicated that more than 80% of cases of SAPHO syndrome in Japan were PAO, originally proposed by Sonozaki et al.

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Objectives: We aimed to evaluate the characteristics, quality, and related factors of the Japanese Clinical Practice Guidelines (CPGs) published in recent years.

Study Design And Setting: In this cross-sectional, meta-epidemiological study, we conducted a Google search for CPGs published by 30 Japanese medical societies that are the basis for training specialties between 2018 and 2019. We used the Appraisal of Guidelines for Research & Evaluation II (AGREE II) tool and the Reporting Items for practice Guidelines in HealThcare (RIGHT) statement to evaluate the quality.

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Background: Plaque psoriasis significantly affects patients' health-related quality of life. To aid treatment decisions, not only objective assessment by physicians but also subjective assessment by patients is important.

Objective: To assess the significance of Dermatology Life Quality Index (DLQI) evaluation at the time of biologics introduction in clinical practice in Japanese patients with plaque psoriasis.

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Importance: Palmoplantar pustulosis (PPP) causes erythematous, scaly plaques with recurrent sterile pustules refractory to treatment and with few randomized clinical trials conducted. Evidence points to involvement of interleukin 23 in the pathogenesis of PPP.

Objective: To determine the efficacy and safety of guselkumab, an anti-IL-23 monoclonal antibody, in Japanese patients with PPP.

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