Comparing tele-pharmacy and standard clinic follow-up for newly initiated warfarin anticoagulation therapy: A retrospective study.

Objectives: To compare the effectiveness of providing telepharmacy anticoagulation to on-site clinics in achieving optimal outcomes for patients newly starting warfarin.

Methods: This single-center retrospective cohort study included adult patients who started warfarin for the first time and were monitored by clinical pharmacists either on-site or via telepharmacy anticoagulation clinics between January 2017 and March 2024. The primary outcome is to compare the time in therapeutic range (TTR) between the 2 groups.

Isotretinoin-induced epistaxis among acne vulgaris patients: A cross sectional study from Saudi Arabia.

Objectives: To assess the prevalence and risk factors of isotretinoin-related epistaxis, among patients of acne vulgaris.

Methods: A retrospective cohort of 230 Saudi patients who received isotretinoin for treatment of acne vulgaris, was included in the study. An online questionnaire was used to collect data regarding demographics and treatment-related adverse events.

Navigating Compound Odontomas: A Case Study of Surgical Intervention and Full-Mouth Rehabilitation in a Pediatric Patient.

Odontomas are the most prevalent odontogenic tumors, often classified as hamartomas due to their slow growth and non-aggressive nature. Typically asymptomatic, they can obstruct the eruption of adjacent teeth. While the exact causes of odontomas remain unclear, potential factors include local trauma, infection, growth pressure, and hereditary influences.

How Reliable is the Assessment of Fusion Status Following ACDF Using Dynamic Flexion-Extension Radiographs?

Study Design: Reliability study.

Objectives: The radiographic diagnosis of non-union is not standardized. Prior authors have suggested using a cutoff of <1 mm interspinous process motion (ISPM) on flexion-extension radiographs, but the ability of practicing surgeons to make these measurements reliably is not clear.

Prognostic Significance of C-MYC and EGFR Overexpression in Gastrointestinal Stromal Tumors: An Immunohistochemical Study.

Introduction: In addition to mutations in KIT and PDGFRA, many other genetic alterations have been described in gastrointestinal stromal tumors (GISTs), including amplifications of C-MYC and EGFR, which are often associated with increased protein expression. The main of this study was to investigate the prognostic significance of C-MYC and EGFR expression in GISTs using immunohistochemistry (IHC).

Methods: We collected all GIST cases over a 16-year period.

Molecular dynamics-based computational investigations on the influence of tumor suppressor p53 binding protein against other proteins/peptides.

The tumor-suppressing p-53 binding protein is a crucial protein that is involved in the prevention of cancer via its regulatory effect on a number of cellular processes. Recent evidence indicates that it interacts with a number of other proteins involved in cancer in ways that are not fully understood. An understanding of such interactions could provide insights into novel ways p53 further exerts its tumour prevention role via its interactions with diverse proteins.

Stability of ADC measurements in diffusion MRI: A multicenter phantom study using multi-point b-values.

Introduction: The apparent diffusion coefficient (ADC) from diffusion MRI provides critical insights into tissue microstructure and is influenced by various b-values. This study aimed to evaluate the impact of multiple b-values on ADC measurements using a multicenter observational approach with different MRI scanners and phantoms.

Methods: The study utilized a liquid isotropic phantom across eight different 1.

Endoscopic retrograde cholangiopancreatography training conditions, results from a pan-European survey: Between vision and reality.

Background: Endoscopic retrograde cholangiopancreatography (ERCP) still has a relatively high complication rate, underscoring the importance of high-quality training. Despite existing guidelines, real-world data on training conditions remain limited. This pan-European survey aims to systematically explore the perceptions surrounding ERCP training.

Resin Infiltration for the Esthetic Improvement of Dental Fluorosis and White Spots: A Case Report.

White spot lesions, characterized by opaque enamel discolorations from early carious lesions, fluorosis, or developmental issues, can be effectively managed through various treatments. Resin infiltration is a unique therapy that bridges the gap between non-invasive and invasive alternatives, potentially delaying the need for restorations by applying a low-viscosity resin that penetrates and seals the lesion, enhancing both appearance and function. This study evaluates the clinical and esthetic outcomes of resin infiltration in a 33-year-old female patient with mild dental fluorosis, who presented with white and brown discolorations on her anterior teeth and a high caries index.

Unexpected Repigmentation of Vitiligo Universalis Following Hemodialysis Initiation: A Rare Case Report and Literature Overview.

Vitiligo is a chronic skin depigmentation disorder affecting 0.2-1.8% of the global population, with a significant prevalence in Saudi Arabia.

Pattern and associated factors of COVID-19 knowledge, attitude and practice (KAP) among COVID-19-comorbid patients: a systematic review and meta-analysis.

Background: The COVID-19 comorbid population is at higher risk of developing severe health issues like acute respiratory distress syndrome, coagulation syndrome, metabolic acidosis, and septic shock, potentially leading to patient death. Patients' knowledge, attitudes, and practices (KAP) significantly influence their response to the pandemic and aid in enhancing health policy implementation.

Objective: To identify and evaluate the pattern and associated factors to COVID-19 knowledge, attitude, and practice among individuals with comorbidities.

Surgical Management of Compound Odontoma in a Pediatric Patient: A Case Report.

Odontomas are the most common type of benign odontogenic tumors, representing around 70% of all odontogenic tumors of the jaws. Odontoma is typically present in the first and second decades of life. Morphologically, compound odontomas appear as deposited dental tissues in a pattern that makes a tooth-like structure.

Acute tubulointerstitial nephritis associated with infliximab therapy in a patient with Crohn's disease: a case report.

We report the case of a 39-year-old man who presented with a history of generalized fatigue, nausea, subjective fever with rigors, and renal dysfunction after receiving infliximab (IFX) therapy for Crohn's disease. A renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After other causes of acute kidney injury were excluded, steroid therapy was initiated, his fever subsided, and kidney function improved.

Residency program directors' views on ideal applicant: a national survey.

Purpose: The aim of this study is to investigate and highlight the most important factors influencing the candidate's selection for residency matching by program directors of surgical and non-surgical specialties in Saudi Arabia.

Method: This cross-sectional study was conducted in the Central, Eastern, Western, Northern, and Southern regions of Saudi Arabia from February 1, 2023, to August 31, 2023. A total of sixty-one program directors completed a questionnaire, which was adapted and validated from a previous study with permission and tailored to meet the objectives of this research.

The evaluation of therapeutic outcomes of biologics in allergic fungal rhinosinusitis: a systematic review and meta-analysis.

Allergic fungal rhinosinusitis (AFRS) is a localized inflammatory, hypersensitivity reaction affecting the nasal cavity and its sinuses secondary to fungal colonization. The burden of surgical revisions and recurrence rates in this disease led to a recent hypothesized advancement in the medical management being experimented, which is the use of biologics. Therefore, this systematic review analyzed nine articles to highlight the significance of biologics in the management of AFRS through a comprehensive strategy, as seen in Supplementary Methods Section (1-9).

A Comparative Study of Columellar Strut and Septal Extension Grafts for Tip Support in Rhinoplasty.

Rhinoplasty is one of the most common aesthetic surgical procedures. Columellar strut and septal extension grafts are commonly used for tip support, but their long-term effectiveness and stability remain debated. This study aims to compare the long-term postoperative stability of these two techniques.

Developing a machine learning model with enhanced performance for predicting COVID-19 from patients presenting to the emergency room with acute respiratory symptoms.

Artificial Intelligence is playing a crucial role in healthcare by enhancing decision-making and data analysis, particularly during the COVID-19 pandemic. This virus affects individuals across all age groups, but its impact is more severe on the elderly and those with underlying health issues like chronic diseases. This study aimed to develop a machine learning model to improve the prediction of COVID-19 in patients with acute respiratory symptoms.

Primary care physicians' knowledge and attitudes about obesity, adherence to treatment guidelines and its' association with confidence to treat obesity at the Saudi Ministry of Interior primary health care centers.

Background And Aim: Many primary care physicians (PCPs) believed that managing overweight and obesity is essential to their jobs, however, many believe that they were doing it ineffectively, unsatisfying, and had negative attitudes. We conducted this study to explore the knowledge, attitudes and adherence to obesity management guidelines, identify potential barriers that may prevent adherence of PCPs to obesity treatment guidelines.

Methods: We conducted this cross-sectional study and conducted a questionnaire sent via email to all PCPs in the Ministry of Interior centers in Riyadh, Al-Kharj, AlQassim, Wadi Ad Dawasir, Hail and Tabuk in Saudi Arabia.

A rare finding of pulmonary nodules in a middle ear neuroendocrine tumor: a case report and review of the literature.

Neuroendocrine tumors (NETs) are usually found in the gastrointestinal tract and pancreas; however, they are rare in the middle ear. The presentation of vague symptoms, such as tinnitus and conductive hearing loss, complicates the diagnosis. We present a 46-year-old male with a history of right ear discharge and a previous canal wall-down mastoidectomy, suspected to have cholesteatoma recurrence.

Inflammatory signaling pathways in Alzheimer's disease: Mechanistic insights and possible therapeutic interventions.

The complex pathophysiology of Alzheimer's disease (AD) poses challenges for the development of therapies. Recently, neuroinflammation has been identified as a key pathogenic mechanism underlying AD, while inflammation has emerged as a possible target for the management and prevention of AD. Several prior studies have demonstrated that medications modulating neuroinflammation might lessen AD symptoms, mostly by controlling neuroinflammatory signaling pathways such as the NF-κB, MAPK, NLRP3, etc, and their respective signaling cascade.