Stability of ADC measurements in diffusion MRI: A multicenter phantom study using multi-point b-values.

Introduction: The apparent diffusion coefficient (ADC) from diffusion MRI provides critical insights into tissue microstructure and is influenced by various b-values. This study aimed to evaluate the impact of multiple b-values on ADC measurements using a multicenter observational approach with different MRI scanners and phantoms.

Methods: The study utilized a liquid isotropic phantom across eight different 1.

A rare case of subcutaneous emphysema in a young and healthy patient with parainfluenza virus 3 pneumonia.

An 18-year-old healthy male complained of a 7-day history of fever, cough, and sore throat, along with a three-day history of left facial swelling. The x-rays revealed subcutaneous emphysema in the chest, neck, face, and mediastinum region (Pneumomediastinum). Furthermore, an area of infiltration was visible, indicating pneumonia.

The value of beta trace protein in CSF-leakage detection confirmed by endoscopic fluorescein evaluation.

Cerebrospinal fluid (CSF) leaks originating from defects within the anterior and middle cranial fossa typically manifest as unilateral clear watery rhinorrhea. Continuous CSF leakage mandates surgical repair due to the risk of meningitis and brain abscess. It can be categorized based on its underlying etiology into traumatic, iatrogenic and non-traumatic CSF leaks.

Optimizing Prostate Imaging Practices in Saudi Arabian Hospitals: A Comprehensive Analysis of PI-RADS Compliance in Multiparametric MRI.

Background: Prostate cancer, a significant contributor to male cancer mortality globally, demands improved diagnostic strategies. In Saudi Arabia, where the incidence is expected to double, this study assessed the compliance of multiparametric MRI (mpMRI) practices with Prostate Imaging-Reporting and Data System version 2 (PI-RADS v2) guidelines across diverse healthcare institutions.

Methods: A survey was distributed to the radiology departments of all tertiary referral hospitals in Saudi Arabia (n=60) to assess their compliance with the technical specifications outlined in PI-RADS v2.

Repurposing the inhibitors of MMP-9 and SGLT-2 against ubiquitin specific protease 30 in Parkinson's disease: computational modelling studies.

Ubiquitin specific protease 30 (USP30) has been attributed to mitochondrial dysfunction and impediment of mitophagy in Parkinson's disease (PD). This happens once ubiquitin that supposed to bind with deformed mitochondria at the insistence of Parkin, it's been recruited by USP30 the distal ubiquitin binding domain. This is a challenge when PINK1 and Parkin loss their functions due to mutation.

Generalized morphea following COVID-19 vaccine: Case report and literature review.

Physicians should be vigilant for COVID-19 vaccine side effects and investigate any associated cutaneous manifestations. This will ultimately facilitate better understanding and recognition of various skin reactions related to the vaccine.

Physicians based emergency medical services for the management of burn injuries in trauma centers of the center region of Saudi Arabia: evaluation of physicians' knowledge and experience.

Background: Medical services at trauma centers regularly encounter severe burn patients but prehospital care of these patients in Saudi Arabia is comparatively unexplored. This study evaluates the knowledge and experience of physicians working in trauma centers of Qassim province of Saudi Arabia for the management of patients with burn injuries.

Methods: This is a cross sectional study performed on 204 physicians working in the trauma centers of Qassim province.

GABA transaminase deficiency. Case report and literature review.

GABA transaminase deficiency should be considered in the differential diagnosis of early onset epileptic encephalopathies. This case was diagnosed post-mortem, but increased vigilance to this will allow for earlier diagnoses in other infants and families. This is a case study which involved diagnosis of a rare neurometabolic disorder in one of the babies in the family and eventual genetic counselling of the family.

Skin burns in Saudi Arabia: causes, management, outcomes and quality of life after skin burns.

Background: Burn is one of the major global health problem causing trauma and stress. A burn injury can cause functional impairment and psychosocial burdens affecting the quality of life. The purpose of this study was to evaluate the life quality after skin burn and patients' satisfaction on skin grafting outcomes in Saudi Arabia.

Gangrenous epiploic appendagitis of sigmoid: a rare cause of acute right iliac fossa pain.

A 42-year-old lady presented to emergency department with a 3 days history of right-sided abdominal pain. She was afebrile, haemodynamically unstable and the initial diagnosis was acute abdomen with unknown pathology. The CT abdomen/pelvis done, which showed well-defined fatty texture at right lower quadrant suggestive of an epiploic appendagitis and left adnexal cyst.

Novel IFT122 mutation associated with impaired ciliogenesis and cranioectodermal dysplasia.

Cranioectodermal dysplasia (CED) is a very rare autosomal recessive disorder characterized by a recognizable craniofacial profile in addition to ectodermal manifestations involving the skin, hair, and teeth. Four genes are known to be mutated in this disorder, all involved in the ciliary intraflagellar transport confirming that CED is a ciliopathy. In a multiplex consanguineous family with typical CED features in addition to intellectual disability and severe cutis laxa, we used autozygosity-guided candidate gene analysis to identify a novel homozygous mutation in IFT122, and demonstrated impaired ciliogenesis in patient fibroblasts.