[Quantitative and ultrastructural characteristics of immunocompetent cells in the mammary gland during pregnancy and lactation].

The quantity and ultrastructure of immunocompetent cells (ICC) were evaluated in the of rat mammary gland in dynamics of pregnancy and lactation. ICC found between the alveolar epithelial cells were represented by monocytes, small and medium lymphocytes, including some granule-containing lymphocytes. The quantity of ICC was found to increase in dynamics of pregnancy and to reach a its maximum on day 3 of lactation.

[The effect of immunomudulin on the structural-functional status of the organs of the immune and hematopoietic systems in chronic toxic hepatitis].

Long-term entry of the hepatotropic poison heliotropin induces the development of chronic active hepatitis attended with disturbance of the immune balance and hematologic disorders in it. Immunomodulin alleviates the destructive changes in the organs of the immune system, stimulates proliferation and differentiation of their cells, and promotes restoration of red blood parameters. It is suggested that immunoglobulin may be a promising measure in complex treatment of chronic liver diseases.

[A comparative study of the efficacy of pharmacological agents in regulating the level of NADPH in the hepatocytes in an acute lesion].

Experiments on mice with acute toxic damage to the liver induced by thioacetamide (200 mg/kg) demonstrated inhibited activity of enzymes glucose-6-phosphate dehydrogenase (G-6-PDH), NADPH-dependent isocitrate dehydrogenase and malate dehydrogenase in the hepatocyte mitochondrial and microsomal-cytosol fractions. Pharmacotherapy with membranostabilizers and cytochrome P-450 inducers activated the enzymes under study, the degree of activation depended on agents used.

[A comparative evaluation of the action of kvamatel and omez on the glutathione system in different sections of the digestive system in experimental duodenal ulcer].

Experiments on male albino rats demonstrated significant changes in the content of oxidized and reduced glutathione in the tissues of the liver, pancreas, stomach, duodenum, and small intestine in acetate ulcer of the duodenum. Experimental therapy with quamatel and particularly with omez led to activation of the glutathione system in the tissues under and in this way increased their resistance to the ulcerogenic effect.

[The efficacy of Kvamatel and Omez in correcting disorders of the antioxidant system of the digestive tract organs in experimental duodenal ulcer].

Experiments were performed on male albino rats with acetate duodenal ulcer to detect the changes in the activity of antioxidant protection enzymes--superoxydedismutase and catalase in the tissues of the liver, stomach, duodenum, and small intestine. The pronounced character of the changes depended on the degree of destruction and involvement of the intestinal system organs in the pathological process. Experimental quamatel or omez therapy corrected the detected changes in the antioxidant status of the tissues.