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[Cell-free fetal DNA detection in maternal plasma using real-time PCR and cycling probe technology for prenatal screening beta-thalassaemia major].
Nan Fang Yi Ke Da Xue Xue Bao
July 2008
Second Clinical College of Jinan University People's Hospital of Shenzhen City, Shenzhen 518020, China.
Objective: To analyze cell-free fetal DNA in maternal plasma for prenatal screening of beta-thalassaemia major.
Methods: Six couples undergoing prenatal diagnosis of beta-thalassaemia (gestational age range 23-26 weeks) were enrolled in this study. The husbands were all carriers of the CD17 (A-->T) mutation, and the wives carried another beta-thalassaemia mutation.