7 results match your criteria: "Second Affiliated Hospital (Shanghai Changzheng Hospital) of Naval Medical University[Affiliation]"

Spinal muscular atrophy (SMA) is a fatal neuromuscular disorder primarily attributed to the homozygous deletion of the survival motor neuron 1 () gene, with disease severity closely correlated to the copy number variations (CNV) of . Conventional methodologies, however, fail to provide a comprehensive gene overview of and are often both time-intensive and costly. In this study, we present a novel one-step MALDI-TOF MS assay for SMA gene testing.

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Article Synopsis
  • * A key challenge in utilizing RNA therapies is effectively delivering them to the central nervous system through the blood-brain barrier (BBB).
  • * This review emphasizes therapeutic RNA, particularly small interfering RNAs (siRNAs), and explores various strategies for treating neurodegenerative diseases to facilitate their clinical application.
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Article Synopsis
  • Diagnosing neurodegenerative diseases (NDDs) is difficult and current therapies are not very effective, but using nanostructures can enhance drug delivery and theranostics.
  • *Hybrid nanostructures, created by combining different types of nanomaterials, offer benefits such as better targeting, biocompatibility, and controlled drug release for treating NDDs.
  • *The paper reviews recent advances in hybrid nanostructures, discusses engineering techniques for their creation, and considers challenges and future possibilities in translating these techniques into therapies for NDDs.*
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Alzheimer's disease (AD) poses a significant burden on the economy and healthcare systems worldwide. Although the pathophysiology of AD remains debatable, its progression is strongly correlated with the accumulation of tau aggregates. Therefore, tau clearance from brain lesions can be a promising strategy for AD therapy.

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Current therapies for Alzheimer's disease used in the clinic predominantly focus on reducing symptoms with limited capability to control disease progression; thus, novel drugs are urgently needed. While nanoparticles (liposomes, high-density lipoprotein-based nanoparticles) constructed with synthetic biomembranes have shown great potential in AD therapy due to their excellent biocompatibility, multifunctionality and ability to penetrate the BBB, nanoparticles derived from natural biomembranes (extracellular vesicles, cell membrane-based nanoparticles) display inherent biocompatibility, stability, homing ability and ability to penetrate the BBB, which may present a safer and more effective treatment for AD. In this paper, we reviewed the synthetic and natural biomembrane-derived nanoparticles that are used in AD therapy.

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Anti-motion imaging photoplethysmography via self-adaptive multi-ROI tracking and selection.

Physiol Meas

November 2023

Shanghai Key Laboratory of Multidimensional Information Processing, East China Normal University, Shanghai 200241, People's Republic of China.

The imaging photoplethysmography (IPPG) technique allows people to measure heart rate (HR) from face videos. However, motion artifacts caused by rigid head movements and nonrigid facial muscular movements are one of the key challenges.This paper proposes a self-adaptive region of interest (ROI) pre-tracking and signal selection method to resist motion artifacts.

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The current therapeutic drugs for Alzheimer's disease only improve symptoms, they do not delay disease progression. Therefore, there is an urgent need for new effective drugs. The underlying pathogenic factors of Alzheimer's disease are not clear, but neuroinflammation can link various hypotheses of Alzheimer's disease; hence, targeting neuroinflammation may be a new hope for Alzheimer's disease treatment.

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