2,095 results match your criteria: "Seborrheic Keratosis"
Primary Systemic Amyloidosis Characterized by Multiple Keratinous Cysts: A Case Report.
J Cutan Pathol
December 2024
Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao, China.
A 67-year-old male presented with plaques around the orbit and ecchymosis on the neck and back of hands for 2 years. Physical examination showed seborrheic-keratosis-like plaques around the orbit, ecchymosis on the neck and back of hands, as well as nail dystrophy. Serum λ light chain was positive.
View Article and Find Full Text PDFIdentification of Associations with Dermatologic Diseases through a Focused GWAS of the UK Biobank.
JID Innov
January 2025
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Article Synopsis
- The UK Biobank contains genotype data for around 500,000 individuals and over 7,000 traits, but many significant relationships are overlooked due to the vast number of tests conducted.
- This study focuses on 13 skin-related conditions and identifies 447 important genetic variants that are more likely to affect protein functions, along with a higher CADD score, indicating their potential impact.
- Through further analysis, the researchers not only confirmed existing pathways related to skin cancers but also discovered five new protein-coding variants linked to conditions like lipomas and systemic lupus erythematosus.
Dermoscopy Training Course Improves Ophthalmologists' Accuracy in Diagnosing Atypical Pigmented Periorbital Skin Lesions.
Diagnostics (Basel)
November 2024
Ophthalmology Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy.
Article Synopsis
- Facial pigmented skin lesions are common, especially in South-European countries, and can be either malignant or benign; diagnosing them can be challenging, even for specialists like dermatologists.* -
- A study was conducted to assess the impact of a one-day dermoscopy training course on ophthalmologists, focusing on their ability to evaluate periorbital pigmented lesions through clinical and dermoscopic analysis.* -
- Results showed that before the training, ophthalmologists had an accuracy of 63.7%, but after the course, their sensitivity improved, indicating a positive effect of the training on their diagnostic skills.*
Collision of Basal Cell Carcinoma with Apocrine-Sebaceous-Follicular Unit Neoplasms.
Dermatopathology (Basel)
October 2024
Dermatology Department, Doctor Jose Molina Orosa Hospital of Lanzarote, 35500 Arrecife, Spain.
Article Synopsis
- Tumor collisions, a rare occurrence with a 0.0017% incidence rate, often involve seborrheic keratosis, melanocytic nevi, and basal cell carcinoma (BCC), and are generally considered incidental events.
- A retrospective study was conducted analyzing hospital records to identify collisions between BCCs or squamous cell carcinoma (SCC) and apocrine-sebaceous-follicular unit (ASFu) neoplasms from 2005 to 2017.
- The study identified 12 collision cases involving BCC and ASFu tumors, primarily in immunosuppressed patients, with many neoplasms located beneath the BCC, leading to new insights and hypotheses about these tumor interactions
Differentiating seborrheic keratosis from melanoma among lesions exhibiting blue-white veil: A retrospective study.
J Am Acad Dermatol
November 2024
Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:
Background: Differentiating melanoma (MM) from seborrheic keratosis (SK) containing a blue-white veil (BWV) remains challenging.
Objective: Identify dermoscopic features that can improve upon the differentiation between MMs and SKs exhibiting BWV.
Methods: Images from 110 MMs and 121 SKs containing BWV were aggregated, and 91 MMs and 62 SKs from this data set had complete agreement on the presence of BWV according to 3 expert dermoscopists.
Evaluation and Comparison of the Efficacy and Safety of Cryotherapy and Electrosurgery in the Treatment of Sebaceous Hyperplasia, Seborrheic Keratosis, Cherry Angioma, and Skin Tag: A Blinded Randomized Clinical Trial Study.
Health Sci Rep
November 2024
Department of Dermatology Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine Iran University of Medical Sciences Tehran Iran.
Article Synopsis
- This study compares cryotherapy and electrosurgery methods for removing bothersome skin conditions like sebaceous hyperplasia and cherry angioma.
- Conducted as an assessor-blind trial with 32 lesions in each treatment group, it assessed patient and physician satisfaction over several follow-up visits.
- Results indicated that while electrosurgery showed higher satisfaction for most conditions, cryotherapy was more effective for treating seborrheic keratosis; some side effects like hypopigmentation were observed in both methods.
Handheld multiphoton and pinhole-free reflectance confocal microscopy enables noninvasive, real-time cross-sectional imaging in skin.
Sci Rep
October 2024
Enspectra Health, Inc., Mountain View, CA, USA.
Biopsy-based histology has been the foundation of disease diagnosis and management for over a century. A long-sought goal in dermatology is the development of an imaging modality with sufficient resolution and compositional detail to noninvasively interrogate skin histology in vivo. Here, we describe a system that achieves this goal using cross-sectionally scanned, multimodal microscopy (cross-modal).
View Article and Find Full Text PDFComparative Analysis of AI Models for Atypical Pigmented Facial Lesion Diagnosis.
Bioengineering (Basel)
October 2024
Dermatology Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy.
Article Synopsis
- Diagnosing atypical pigmented facial lesions (aPFLs) is difficult for dermatologists and crucial for patient care, as incorrect diagnoses can lead to mismanagement and delays in treatment.
- The study compared machine learning and deep learning models to improve diagnostic accuracy of aPFLs using 1197 dermoscopic images classified into seven categories, focusing on the potential role of AI in supporting clinicians.
- Results showed that while dermatologists were 71.2% accurate in identifying malignant versus benign lesions, their accuracy dropped to 42.9% when distinguishing among specific lesions, highlighting the complexity of aPFL evaluations.
Article Synopsis
- The study investigates the role of Demodex mites in the development of eyelid papillomas, focusing on how their presence may influence the tumor's histomorphological characteristics.
- Histomorphological examinations revealed demodectic infection indicators, such as cystic formations and remnants of the mite, in nearly half of the analyzed cases, found within tumor tissues and surrounding structures.
- The findings suggest that these cavity defects created by mite activity may serve as indicators of Demodex infestation, with implications for understanding their impact on various eyelid tumors, including keratoacanthomas and senile keratosis.
Dermatoscopic Radial Rippling of Pigment: A Potential Indicator of Pigmented Bowen's Disease.
Skinmed
October 2024
Empire Dermatology (Private Practice), Syracuse, NY.
Article Synopsis
- - Pigmented Bowen's disease (pBD) is a rare form of Bowen's disease, making up only 1.67%-5.5% of lesions, and it can be mistaken for various skin conditions like actinic keratosis and melanoma.
- - This skin condition usually appears as a flat or slightly raised, scaly, and well-defined plaque, mainly affecting individuals in their sixties and is generally asymptomatic.
- - Key risk factors for developing pBD include HPV infection, exposure to arsenic and sunlight, ionizing radiation, and skin trauma.
More than one shade of pink as a marker of early amelanotic/hypomelanotic melanoma.
J Dermatol
July 2024
Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
Article Synopsis
- * The study analyzed 133 digital images of skin lesions diagnosed as either early amelanotic melanoma or non-melanocytic lesions, using assessments by three blinded dermatologists.
- * Results indicated specific features in lesions (like multiple shades of pink and irregular dots) can significantly increase the likelihood of accurate diagnosis of early amelanotic melanoma compared to non-melanoma lesions.
Seborrheic keratosis-like mycosis fungoides: A rare variant with clinical, dermatoscopic, and dermatopathological features.
J Dtsch Dermatol Ges
October 2024
Department of Dermatology and Veneral Diseases, Faculty of Medicine, Ankara University, Ankara, Turkey.
Seborrheic Keratosis: Is it What it Looks Like? A Case Report with Review of Literature.
Indian J Otolaryngol Head Neck Surg
October 2024
Indian Naval Ship and Hospital Jeevanti, Vasco Da Gama, Goa India.
Article Synopsis
- Seborrheic Keratosis are benign skin tumors commonly observed in older adults, particularly those in their fifties, usually located on the head and neck.
- The exact causes and links between Seborrheic Keratosis and malignant skin tumors like Malignant Melanoma and Basal Cell Carcinoma are not well understood, emphasizing the need for proper treatment options for affected patients.
- A case is presented of a 54-year-old male whose skin lesion resembled Malignant Melanoma but was ultimately diagnosed as Seborrheic Keratosis through histopathologic examination.
Management of dermatosis papulosa nigra: a systematic review.
Int J Dermatol
October 2024
Department of Dermatology, LSU Health Sciences Center-New Orleans School of Medicine, New Orleans, LA, USA.
Article Synopsis
- Dermatosis papulosa nigra (DPN) is a benign skin condition characterized by hyperpigmented, pedunculated papules, primarily affecting individuals with darker skin tones, and can lead to discomfort and distress.
- This study reviews existing literature on treatment options for DPN, encompassing 17 relevant publications, including various study types like cohort and randomized controlled trials.
- Treatment methods include excision, curettage, cryotherapy, and laser therapies, but may cause side effects like postinflammatory hyperpigmentation; treatment strategies should be tailored to individual factors such as skin type, costs, and potential adverse effects.
Untapped saga of paediatric nevo-blaschkoid seborrheic keratosis.
BMJ Case Rep
October 2024
Department of Dermatology, Venereology and Leprosy, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.
Article Synopsis
- - Seborrheic keratosis (SK) is usually a harmless skin growth in adults, but its rare occurrence in infants presents diagnostic challenges for doctors, particularly when it resembles another condition called epidermal nevus (EN).
- - The case discusses a child with a unique variant of SK showing a specific pattern (nevo-blaschkoid) that makes it hard to classify, but certain microscopic features can help distinguish it from EN.
- - A shave biopsy was performed on the child's skin lesion, confirming it as SK and allowing for effective removal, addressing both diagnosis and treatment in one procedure.
Malignant Epithelioid Neoplasm versus Dedifferentiated Malignant Melanoma: A Case Report.
Diseases
August 2024
Department of Medicine, Northwell Health-Staten Island University Hospital, Staten Island, NY 10305, USA.
Article Synopsis
- The case discusses a rare occurrence of poorly differentiated epithelioid carcinoma metastasizing to the axillary node in a 75-year-old war veteran, highlighting diagnostic difficulties due to the tumor's heterogeneous expression.
- The patient's symptoms included an axillary mass, incontinence, leg weakness, fever, night sweats, and significant weight loss, leading to high levels of leukocytosis, anemia, and thrombophilia upon admission.
- The excisional biopsy revealed complex immunohistochemical staining patterns, complicating the diagnosis, but ultimately underscored the importance of considering poorly differentiated epithelial carcinoma in patients with axillary masses and related symptoms for timely treatment.
Testing the ability of artificial intelligence chatbots and dermatologic diagnosis mobile applications to diagnose melanoma and seborrheic keratosis.
J Am Acad Dermatol
January 2025
Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, Massachusetts. Electronic address:
Pigmented basal cell carcinoma mimicking nodular melanoma.
BMJ Case Rep
September 2024
Department of Pathology, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.
Article Synopsis
- Basal cell carcinoma (BCC) is the most common type of primary skin cancer, with pigmented BCC being a rare variant that can resemble nodular melanoma (NM).
- A case is presented involving a 40-something woman with a hyperpigmented nodule on her cheek that looked like pigmented NM, but dermoscopy revealed distinct features.
- After initial biopsy showed signs of trichoepithelioma, complete excision confirmed it was pigmented BCC; awareness of this rare presentation is essential for proper diagnosis and management, especially in dark-skinned patients.
Clinical aspects and risks of the phenol/croton oil.
Exp Ther Med
November 2024
Artion Plastic Surgery Center, 15451 Athens, Greece.
Article Synopsis
- - Phenol/croton oil is a powerful chemical peel used for deep skin resurfacing, promoting skin renewal, but its risks and effectiveness have not been widely researched.
- - A study involving 64 patients treated from 2014 to 2023 showed significant improvements in wrinkles and acne scars, with successful treatment of seborrheic keratosis while highlighting the mild and reversible nature of any side effects.
- - Despite its efficacy in skin rejuvenation, the use of phenol/croton oil should be approached with caution due to possible complications associated with the procedure.
Epidermodysplasia Verruciformis (Lewandowsky and Lutz's Dysplasia).
Skinmed
September 2024
Pathology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
A woman in her twenties, with a non-consanguineous marriage, presented to the dermatology clinic with asymptomatic lesions on her face, neck, trunk, and extremities for the past 12 years. The general physical and systemic examination was unremarkable. Cutaneous examination revealed multiple hypopigmented to a few hyperpigmented, slightly scaly tinea versicolor-like macules distributed predominantly on the neck, upper portion of the back, and distal parts of the extremities (Figures 1-5).
View Article and Find Full Text PDFDiagnostic dilemma in pigmented basal cell carcinoma: A case report.
J Educ Health Promot
July 2024
Department of Hospital Administration, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Article Synopsis
- * The study conducted in 2023 at a cancer center in North India focused on pigmented BCC, a rare variant that shows increased pigmentation and can be mistaken for other skin conditions.
- * To prevent BCC, it's recommended to avoid direct sunlight and use sunscreen when exposure is unavoidable.
The utility and reliability of a deep learning algorithm as a diagnosis support tool in head & neck non-melanoma skin malignancies.
Eur Arch Otorhinolaryngol
September 2024
Department of Otorhinolaryngology-Head & Neck Surgery, Osakidetza, Donostia University Hospital, San Sebastian, 20014, Spain.
Article Synopsis
- Non-melanoma skin cancers like basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are increasingly common, necessitating better diagnostic tools.
- A prospective study evaluated a CE-certified deep learning-based medical device for diagnosing skin lesions in a head & neck outpatient clinic, involving 135 patients with a focus on BCC, cSCC, and benign lesions.
- The device showed over 90% accuracy in identifying malignant lesions as one of the top-5 diagnoses, indicating its potential for early detection and treatment of skin cancers, and further research is recommended to explore its applications in various medical settings.
Comparison of Ophthalmologists versus Dermatologists for the Diagnosis and Management of Periorbital Atypical Pigmented Skin Lesions.
J Clin Med
August 2024
Department of Ophthalmology, University of Catania, 95123 Catania, Italy.
Article Synopsis
- Lentigo maligna (LM) and lentigo maligna melanoma (LMM) are key melanoma subtypes with an incidence of 1.37 per 100,000 in the U.S., often misdiagnosed, especially among the elderly, leading to treatment delays.
- A study evaluated the diagnostic abilities of ophthalmologists in identifying pigmented skin lesions in the periorbital region by reviewing 79 cases, comparing their results with dermatologists.
- Results showed that ophthalmologists had a diagnostic accuracy of 63.5% and lower sensitivity compared to dermatologists (33.3% vs. 46.9%), with a significantly higher percentage of ophthalmologists rating cases as "difficult" and suggesting fewer biopsies
Ultraviolet induced fluorescence dermoscopy in seborrheic keratosis structures.
J Am Acad Dermatol
December 2024
Dermato-Oncology Clinic, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Causality of inflammatory bowel disease and seborrheic keratosis: A bidirectional two-sample Mendelian randomization study.
Skin Res Technol
August 2024
Department of Dermatology, The Second Hospital of Dalian Medical University, Dalian, China.
Article Synopsis
- Previous studies hinted at a possible connection between inflammatory bowel disease (IBD) and seborrheic keratosis (SK), although it's unclear if this connection is direct or influenced by other factors.
- A two-sample Mendelian randomization analysis was conducted to explore this relationship, using various genetic data sources and methods to assess causality between IBD (including Crohn's disease and ulcerative colitis) and SK.
- The results indicated that IBD and Crohn's disease increase the risk of developing SK, while SK does not appear to influence the onset of IBD.