2,760 results match your criteria: "Sebaceous Carcinoma"

Sebaceous Carcinoma in the Right Inguinal Region with Multiple Metastases and a Poor Prognosis: A Case Report.

Cancer Manag Res

December 2024

Department of Oncology and Hematology, Dujiangyan People's Hospital, Chengdu, Sichuan, People's Republic of China.

Introduction: Sebaceous carcinoma (SC) is a rare malignancy and can be divided into two types, ocular and extra-ocular SC. Extra-ocular SC is typically associated with a better prognosis than ocular SC. However, extra-ocular SCs located in atypical areas, such as the inguinal region, along with multiple metastases, are uncommon and present significant challenges, often leading to poorer outcomes.

View Article and Find Full Text PDF

Hidradenocarcinoma (HAC) is a rare malignant neoplasm originating from eccrine sweat glands, often presenting diagnostic challenges because of its resemblance to other malignancies, particularly breast cancer when occurring in the chest region. This report describes 2 cases of HAC with axillary lymph node metastasis, both initially misinterpreted clinically. The first case involved a 63-year-old woman with a sternal mass, near the right breast, initially suspected to be a sebaceous cyst.

View Article and Find Full Text PDF

Background: Controversy exists around the optimal timing of resection of nevus sebaceous (NS). The authors aim to determine optimal timing of NS resection and identify predictors of surgical outcomes and secondary intralesional neoplasms.

Methods: Retrospective chart review of all patients with biopsy-proven NS diagnosis treated at the authors' institution between 1987 and 2024.

View Article and Find Full Text PDF

Malignant cutaneous adnexal tumors (MCATs) are rare. Previous population-based studies to determine the clinical features and prognosis of MCATs mainly included Caucasian patients, and the characteristics of Asian patients with MCATs have not yet been investigated. We aimed to investigate the characteristics of Asian patients with MCAT using a Japanese database.

View Article and Find Full Text PDF
Article Synopsis
  • The UK Biobank contains genotype data for around 500,000 individuals and over 7,000 traits, but many significant relationships are overlooked due to the vast number of tests conducted.
  • This study focuses on 13 skin-related conditions and identifies 447 important genetic variants that are more likely to affect protein functions, along with a higher CADD score, indicating their potential impact.
  • Through further analysis, the researchers not only confirmed existing pathways related to skin cancers but also discovered five new protein-coding variants linked to conditions like lipomas and systemic lupus erythematosus.
View Article and Find Full Text PDF

Sebaceous carcinoma of the back: a case report and literature review.

J Med Case Rep

November 2024

Department of Surgery, School of Medicine, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá D.C., Colombia.

Background: Extra ocular sebaceous carcinoma is a very rare, aggressive, malignant tumor arising in the adnexal epithelium of sebaceous gland that account for only about 25% of all sebaceous carcinomas (Wick et al. in Cancer 56(5):1163-72, 1985). The diagnosis of this tumor is difficult because its clinical appearance is atypical.

View Article and Find Full Text PDF

Sebaceous carcinoma is difficult to distinguish from chalazion due to their rarity and clinicians' limited experience. This study investigated the potential of AI-generated image training to improve diagnostic skills for these eyelid tumors compared to traditional video lecture-based education. Students from Orthoptics, Optometry, and Vision Research (n = 55) were randomly assigned to either an AI-generated image training group or a traditional video lecture group.

View Article and Find Full Text PDF
Article Synopsis
  • Tumor collisions, a rare occurrence with a 0.0017% incidence rate, often involve seborrheic keratosis, melanocytic nevi, and basal cell carcinoma (BCC), and are generally considered incidental events.
  • A retrospective study was conducted analyzing hospital records to identify collisions between BCCs or squamous cell carcinoma (SCC) and apocrine-sebaceous-follicular unit (ASFu) neoplasms from 2005 to 2017.
  • The study identified 12 collision cases involving BCC and ASFu tumors, primarily in immunosuppressed patients, with many neoplasms located beneath the BCC, leading to new insights and hypotheses about these tumor interactions
View Article and Find Full Text PDF

Case report: A rare case of oral sebaceous carcinoma in the upper lip.

Pathol Oncol Res

November 2024

King Abdulaziz Medical City, Prince Noorah Oncology Center, Jeddah, Saudi Arabia.

Article Synopsis
  • Sebaceous carcinoma (SC) is a rare and aggressive skin cancer that develops in the sebaceous glands, with few documented cases occurring on the lips.
  • A 47-year-old male smoker presented with a painless, irregularly shaped mass on his upper lip that was biopsied, revealing malignant basaloid cells with sebaceous differentiation.
  • The case highlights the unique characteristics of SC, including its histogenesis and treatment options, while emphasizing the importance of further research due to its rarity.
View Article and Find Full Text PDF

A novel lynch syndrome kindred with hereditary adrenal cortical carcinoma.

Cancer Genet

November 2024

Eastern Virginia Medical School, Norfolk, VA, USA; Virginia Oncology Associates, Norfolk, VA, USA.

Background: Adrenal cortical carcinoma (ACC) is an extremely rare malignancy, and advanced ACC carries a very poor prognosis. Early detection is critical since early-stage disease can be cured with surgical resection. ACC can be seen in Lynch syndrome; this case and review of the literature provide insight as to the potential biological origin of this malignancy.

View Article and Find Full Text PDF

Poorly differentiated sebaceous carcinoma of the lacrimal sac in a young adult: A case report.

SAGE Open Med Case Rep

November 2024

Department of Orbit and Oculoplasty, Sadguru Netra Chikitsalaya, Chitrakoot, Uttar Pradesh, India.

Lacrimal sac and nasolacrimal duct tumors are extremely rare, and most of them are malignant tumors, which are often misdiagnosed as chronic dacryocystitis. We herein report a rare case of a 29-year-old female, presented with a history of watering in the right eye associated with a rapidly progressive mass for 4 months near the medial canthus. Further clinical examination revealed firm, non-tender mass occupying the lacrimal sac fossa extending above the medial canthus.

View Article and Find Full Text PDF

Synchronous colorectal carcinoma is having more than 1 primary carcinoma detected in a single patient at the same time or within 6 months of tumor diagnosis. Metachronous colorectal carcinoma is the presence of more than 1 primary carcinoma detected consecutively in a single person after a set time interval. Patients with Lynch syndrome and Muir-Torre syndrome (a subset of Lynch syndrome) inherit a germline mutation in 1 of the mismatch repair (MMR) genes.

View Article and Find Full Text PDF

Sebaceous Hyperplasia of the Face: A Case Report.

Cureus

October 2024

Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.

Article Synopsis
View Article and Find Full Text PDF

[Sebaceous gland carcinoma of the eyelid co-occurred with other tumors: a report of four cases].

Zhonghua Yan Ke Za Zhi

November 2024

Tianjin Eye Hospital, Nankai University Affiliated Eye Hospital, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin 300020, China.

Article Synopsis
  • The article discusses four cases of sebaceous gland carcinoma of the eyelid, with three cases associated with other ocular tumors and two with visceral cancers, including chronic lymphocytic leukemia/small lymphocytic lymphoma.
  • Immunohistochemistry and whole-exome sequencing showed that the cases with visceral cancers did not qualify for Muir-Torre syndrome, and two cases revealed mutations in the ZNF750 gene.
  • Surgical treatments included tumor excision in three cases and enucleation in one, with follow-ups indicating no recurrence in three patients, while one patient unfortunately died from ovarian cancer metastasis.
View Article and Find Full Text PDF

Intraepithelial Sebaceous Gland Carcinoma: A Multicenter Retrospective Case Series.

Ophthalmic Plast Reconstr Surg

November 2024

Department of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, South Australia.

Purpose: Intraepithelial sebaceous gland carcinoma is a rare form of sebaceous gland carcinoma, with 10 published case reports to date. The authors report the clinical, histological, and prognostic features of this rare carcinoma.

Methods: This is a multicenter retrospective case series of patients from 3 Australian sites.

View Article and Find Full Text PDF
Article Synopsis
  • - Sebaceoma is a rare benign tumor with sebaceous gland characteristics, commonly found on the face, scalp, or trunk, and extremely seldom in the eyelid region.
  • - Only five cases of eyelid sebaceoma have been documented, with one case linked to a Meibomian gland, emphasizing the rarity of this condition.
  • - A recent case is reported involving a 64-year-old male with sebaceoma of the left lower eyelid margin, diagnosed through histopathological examination amidst challenges in distinguishing it from other skin lesions.
View Article and Find Full Text PDF
Article Synopsis
  • Primary sebaceous and lipid-rich carcinomas are very rare types of skin cancer, featuring distinct cellular characteristics.
  • Sebaceous carcinoma cells are large and oval, while smaller, fusiform cells are found at the tumor's periphery; lipid-rich carcinoma contains multiple cell types.
  • Prognosis for these tumors varies significantly, with some exhibiting excellent outcomes and others showing aggressive behavior with early metastasis.
View Article and Find Full Text PDF
Article Synopsis
  • Intraductal carcinoma (IDC) is a rare salivary gland tumor, and this report focuses on a unique case of apocrine IDC found in a 60-year-old male's parotid gland that showed unusual sebaceous-like features.
  • The tumor was characterized microscopically by a papillary growth pattern with apocrine cells and areas resembling sebaceous cells, alongside notable genetic mutations in the AKT1 and BRAF genes.
  • Understanding the characteristics of this IDC variant is crucial, as it is a slow-growing disease, and more research is needed to determine its classification and potential connection to other salivary gland tumors.
View Article and Find Full Text PDF