976 results match your criteria: "Sebaceous Adenoma"

Sebaceous gland hyperplasia is a benign cutaneous entity commonly seen in older men. Occasionally, it can develop in young patients on immunosuppression with cyclosporine or in adolescent boys in the peripubertal age group. It is extremely rare in young children with no reports of eyelid involvement.

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Synchronous colorectal carcinoma is having more than 1 primary carcinoma detected in a single patient at the same time or within 6 months of tumor diagnosis. Metachronous colorectal carcinoma is the presence of more than 1 primary carcinoma detected consecutively in a single person after a set time interval. Patients with Lynch syndrome and Muir-Torre syndrome (a subset of Lynch syndrome) inherit a germline mutation in 1 of the mismatch repair (MMR) genes.

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Article Synopsis
  • - Sebaceoma is a rare benign tumor with sebaceous gland characteristics, commonly found on the face, scalp, or trunk, and extremely seldom in the eyelid region.
  • - Only five cases of eyelid sebaceoma have been documented, with one case linked to a Meibomian gland, emphasizing the rarity of this condition.
  • - A recent case is reported involving a 64-year-old male with sebaceoma of the left lower eyelid margin, diagnosed through histopathological examination amidst challenges in distinguishing it from other skin lesions.
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Gardner syndrome (GS) is a subtype of familial adenomatous polyposis (FAP) characterized by colorectal polyps, multiple osteomas, soft tissue tumors, and specific oral manifestations, such as jaw osteomas. GS is caused by mutations in the APC gene, resulting in a nonfunctional protein. This study reports a comprehensive clinical evaluation and genetic analysis of a Tunisian family affected by GS.

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  • Intraductal carcinoma (IDC) is a rare salivary gland tumor, and this report focuses on a unique case of apocrine IDC found in a 60-year-old male's parotid gland that showed unusual sebaceous-like features.
  • The tumor was characterized microscopically by a papillary growth pattern with apocrine cells and areas resembling sebaceous cells, alongside notable genetic mutations in the AKT1 and BRAF genes.
  • Understanding the characteristics of this IDC variant is crucial, as it is a slow-growing disease, and more research is needed to determine its classification and potential connection to other salivary gland tumors.
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  • The study investigates the role of Demodex mites in the development of eyelid papillomas, focusing on how their presence may influence the tumor's histomorphological characteristics.
  • Histomorphological examinations revealed demodectic infection indicators, such as cystic formations and remnants of the mite, in nearly half of the analyzed cases, found within tumor tissues and surrounding structures.
  • The findings suggest that these cavity defects created by mite activity may serve as indicators of Demodex infestation, with implications for understanding their impact on various eyelid tumors, including keratoacanthomas and senile keratosis.
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Identification of a novel TSC1 variant in a family with developmental and epileptic encephalopathies: A case report and literature review.

Medicine (Baltimore)

October 2024

Department of Neurology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.

Article Synopsis
  • Tuberous sclerosis (TSC) is a genetic condition caused by mutations in the TSC1 and TSC2 genes, leading to various health issues for patients and families due to challenges in diagnosis and unverified gene variants.
  • A 33-year-old Chinese male patient with TSC presented symptoms like intellectual disability, epilepsy, and organ tumors, prompting genetic testing to find the harmful variant.
  • The patient was diagnosed with TSC after identifying a specific mutation and was treated with medications, but he continues to experience significant health challenges, highlighting the variability of TSC symptoms.
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Pleomorphic adenoma: Indeed, a versatile tumor.

J Cancer Res Ther

July 2024

Department of General Surgery, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Article Synopsis
  • Pleomorphic adenoma is the most prevalent benign tumor found in salivary glands, primarily affecting the parotid gland but can also appear in other salivary glands.
  • The tumor exhibits various types of metaplasia, including squamous, osseous, oncocytic, sebaceous, and adipocytic metaplasia, with tyrosine crystalloids sometimes present.
  • The study focuses on these metaplasias and the occurrence of tyrosine crystals in pleomorphic adenomas, highlighting the tumor’s complex nature.
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Oral sialadenoma papilliferum with kras mutation in a patient with linear nevus sebaceous syndrome.

Pathologica

August 2024

Unit of Anatomic Pathology, Bellaria Hospital, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Article Synopsis
  • Linear nevus sebaceous syndrome (LNSS) is a rare skin and neurological disorder that involves sebaceous nevi and other genetic lesions.
  • Sialadenoma papilliferum (SP) is a rare benign tumor in the mouth, usually linked to mutations in BRAF or HRAS genes.
  • This report presents a unique case of a young girl with LNSS who developed SP with a KRAS mutation, marking it as the first documented instance of this mutation related to LNSS.
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  • Sebaceous carcinoma is a type of skin cancer that's not very common, but it still has about 1,000 cases a year in the U.S., and scientists are trying to find better ways to tell it apart from non-cancerous skin growths.* -
  • Researchers studied the DNA and RNA of skin tumors from different hospitals to understand what makes these tumors different and how they develop.* -
  • They found specific changes in the tumors that could help doctors diagnose sebaceous carcinoma better, and they believe that new treatments, like using immunotherapy and targeting cholesterol production, might work well.*
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  • - Mature teratoma is a benign tumor that contains various tissue types from the three primary germ layers: mesoderm, ectoderm, and endoderm.
  • - This report details a rare case of a lactating adenoma developing from a mature teratoma in a pregnant woman, making it the fifth known case globally and the first to present both choroidal plexus and lactating adenoma findings.
  • - The tumor measured 10x7x5 cm, displaying mixed solid and cystic areas with features of mammary tissue, confirmed through immunohistochemistry which showed positivity for estrogen and progesterone receptors, indicating hyperplastic changes in ducts and acini.
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The role of aquaporin proteins (AQPs) in tumor biology has attracted attention over the past 20 years. However, the expression profiles of AQPs in canine sebaceous gland tumors remain obscure. This study was performed to clarify the expression of AQP1, 3, 5, the most studied AQPs in tumor biology, in sebaceous adenoma and sebaceous epithelioma.

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Article Synopsis
  • Syringocystadenoma papilliferum is a rare, harmless skin growth that can be found on the scalp and is often linked to a type of birthmark.
  • A teenage girl had a different type of skin cancer on her toe that came back after being removed twice without testing.
  • The tests (or biopsy) showed that it might be a syringocystadenoma papilliferum but also raised worries about a more aggressive cancer, stressing the need for testing when doctors remove strange growths.
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  • * Diagnosing this tumor involves differentiating it from several other skin conditions, including hemangiomas, melanomas, and infected sebaceous cysts.
  • * The article discusses a specific case of a large eccrine acrospiroma found on the left thigh of a 56-year-old man, highlighting the clinical and morphological analysis involved.
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Article Synopsis
  • Syringocystadenoma papilliferum (SCAP) is a harmless lump usually found on the scalp and face, often starting in childhood.
  • A 55-year-old man had a rare SCAP lump on the back of his knee that didn't hurt and was small in size.
  • The doctors took a sample of the lump and decided to remove it, as this type of SCAP is very uncommon in that area of the body.
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  • Syringocystadenocarcinoma papilliferum (SCACP) is a rare and aggressive cancer originating from skin appendage glands, often linked to previous skin conditions like syringocystadenoma papilliferum or nevus sebaceus.
  • A systematic review analyzed 78 case studies from 1980 to 2024, focusing on clinical features, diagnosis, treatments, and outcomes of SCACP, which commonly affects older adults and presents as ulcerated nodules on the scalp.
  • The study emphasizes the importance of surgical treatment, particularly Mohs micrographic surgery, and suggests more research into standardized treatment protocols and targeted therapies to better improve patient outcomes and understanding of its relationships with other skin conditions.
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  • Sebaceous gland tumors, accounting for 21-35% of skin tumors in dogs, can be classified as benign adenomas or malignant epitheliomas based on histopathology.
  • The distinction between sebaceous adenomas and epitheliomas involves the percentage of reserve cells, with the latter having 90% or more, although this criterion alone is insufficient for accurate diagnosis.
  • A study of 14 canine tumors found a need to adjust the classification criteria to 50% reserve cells, revealing that borderline and epithelioma tumors exhibited higher cell proliferation rates compared to adenomas.
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  • - Muir-Torre syndrome is linked to systemic malignancies and sebaceous tumors (like adenomas or carcinomas) caused by mutations in mismatch repair genes, with immunosuppression potentially promoting tumor development.
  • - The syndrome is observed more frequently and earlier in kidney transplant recipients due to their higher exposure to immunosuppressive medications, and changing medication types can reduce tumor development.
  • - Researchers suggest that genetic testing for mismatch repair gene mutations should be standard for all patients who present with sebaceous neoplasms associated with Muir-Torre syndrome, whether they are immunocompetent or immunosuppressed.
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Oral cavity salivary gland pleomorphic adenoma: a histomorphological case series.

Ann Diagn Pathol

August 2024

Department of Pathology, Seth G.S. medical college and K.E.M.H., Parel, Mumbai 400012, Maharashtra, India. Electronic address:

Article Synopsis
  • Pleomorphic adenoma (PA) is a common benign salivary gland tumor with varying histopathological features and a mix of epithelial and mesenchymal cells.* -
  • A study of 10 PA cases revealed a mean age of 33.5 years, with no gender bias; all patients had asymptomatic masses, and 50% exhibited a cellular subtype.* -
  • Key findings included capsular infiltration in 20% of cases, distinct cellular characteristics among subtypes, and significant features like capsular invasion and squamous metaplasia that may indicate a risk of malignancy.*
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A Unique Presentation Site of Pleomorphic Adenoma in a Young Woman: A Case Report.

Plast Reconstr Surg Glob Open

March 2024

From the Department of Plastic Surgery and Burns, King Saud Medical City, Riyadh, Saudi Arabia.

Article Synopsis
  • Pleomorphic adenoma, related to mixed cutaneous tumors and chondroid syringomas, typically arises from skin, salivary, and lacrimal glands, often affecting middle-aged men as a firm nodular lesion in the periorbital area.
  • A unique case of a young woman showed a pleomorphic adenoma as a small, nontender lump near her eyebrow, initially misdiagnosed as a sebaceous cyst, but confirmed after surgical excision.
  • Despite its rarity, pleomorphic adenoma should be considered in differential diagnoses for skin lesions in the head and neck, and complete surgical excision is essential for accurate assessment and to minimize recurrence risks.
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[Clinical diagnosis and treatment of 14 cases of scar cancer ulcer wound on head and face].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi

March 2024

Department of Burn and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, 563000, P. R. China.

Article Synopsis
  • The study analyzed clinical characteristics of scar cancer ulcer wounds on the head and face, focusing on diagnosis and treatment options for 14 patients admitted between January 2021 and March 2022.
  • The patients had varied backgrounds, with ages ranging from 21 to 81 years, and injuries from multiple causes such as trauma, scratches, and burns; squamous cell carcinoma was the most common diagnosis.
  • Follow-up results indicated a 14% recurrence rate, with varying success in surgical treatments, including extensive resections and different repair methods, ultimately showing some patients responded well to traditional Chinese medicine after failure of chemotherapy.
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Article Synopsis
  • Cutaneous sebaceous neoplasia includes a range of tumors from benign to malignant, with the key characteristic being sebaceous differentiation, although poorly-differentiated sebaceous carcinoma can resemble other skin tumors.
  • Accurate classification of sebaceous carcinoma is important for diagnosis and its potential link to Muir-Torre syndrome, with androgen receptor (AR) showing better sensitivity and specificity than Preferentially expressed Antigen in MElanoma (PRAME) for diagnosis.
  • PRAME expression is infrequent in poorly differentiated sebaceous carcinoma and has low sensitivity (22%), while AR shows moderate sensitivity (66%) and high specificity (92%), indicating AR is a superior diagnostic marker.
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Muir-Torre Syndrome with Novel Mutation in the MSH2 Gene.

Acta Dermatovenerol Croat

December 2023

Eda Ustaoglu, MD, University of Health Sciences, Bursa City Hospital, Dogankoy District, 16110 Nilufer, Bursa, Turkey;

Article Synopsis
  • * It results from mutations in mismatch repair genes that lead to various internal malignancies, mostly affecting organs like the colon, endometrium, and breast.
  • * The identification of skin tumors is crucial for diagnosing MST and facilitating the early detection of serious internal cancers, as demonstrated by a patient with sebaceous adenomas and a newly found genetic mutation.
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