397 results match your criteria: "Scripps Memorial Hospital[Affiliation]"
Surgery
September 2021
University of California, Irvine (UCI), Department of Surgery, Orange, CA. Electronic address:
Background: The rapid spread of coronavirus disease 2019 in the United States led to a variety of mandates intended to decrease population movement and "flatten the curve." However, there is evidence some are not able to stay-at-home due to certain disadvantages, thus remaining exposed to both coronavirus disease 2019 and trauma. We therefore sought to identify any unequal effects of the California stay-at-home orders between races and insurance statuses in a multicenter study utilizing trauma volume data.
View Article and Find Full Text PDFJ Trauma Acute Care Surg
May 2021
From the Scripps Memorial Hospital La Jolla (WLB, FZZ, MC, KBS), La Jolla, CA; Maine Medical Center (BM), Portland, ME; Memorial Hermann Hospital (MM), Houston, TX; University of Oklahoma (JL), Oklahoma City, OK; Ryder Trauma Center (SB), Miami, FL; University of California-San Diego (JW), San Diego, CA; San Francisco General Hospital (RC, LK), San Francisco, CA; University of Calgary (CCGB), Calgary, Alberta, Canada; University of California-Irvine (JN), Irvine, CA; North Memorial Health Hospital (MW), Robbinsdale, MN; University of California-Davis (GJJ), Sacramento, CA; Grady Memorial Hospital (SRT), Atlanta, GA; Hadassah- Hebrew University Medical Center (MB), Jerusalem, Israel; Grant Medical Center (CS), Columbus, OH; Ernest E. Moore Shock Trauma Center at Denver Health (EEM), Denver, CO.
Background: Outcomes following pancreatic trauma have not improved significantly over the past two decades. A 2013 Western Trauma Association algorithm highlighted emerging data that might improve the diagnosis and management of high-grade pancreatic injuries (HGPIs; grades III-V). We hypothesized that the use of magnetic resonance cholangiopancreatography, pancreatic duct stenting, operative drainage versus resection, and nonoperative management of HGPIs increased over time.
View Article and Find Full Text PDFJ Trauma Acute Care Surg
August 2021
From the Department of Surgery (M.S.), Macerata Hospital, Macerata; General, Emergency and Trauma Surgery Department (L.A.), Bufalini Hospital, Cesena, Italy; Trauma and Acute Care Surgery (W.A.B.), Scripps Memorial Hospital, La Jolla, California; General, Emergency and Trauma Surgery Department (F.C.), Pisa University Hospital, Pisa, Italy; Department of General and Metabolic Surgery (B.D.S.), Poissy and Saint Germain en Laye Hospitals, Poissy, France; Abdominal Center (A.L., M.T.), Helsinki University Hospital Meilahti, Finland; Division of General Surgery (Y.K.), Rambam Health Care Campus, Haifa, Israel; Ernest E. Moore Shock Trauma Center at Denver Health (E.E.M.), Denver, Colorado; and Department of Emergency Surgery (F.C.), Parma Maggiore Hospital, Parma, Italy.
In the last three decades, the dramatic worldwide increase in incidence and severity of Clostridioides difficile infection (CDI) (formerly Clostridium difficile infection) has made CDI a global public health challenge. Surgery is a known risk factor for development of CDI yet surgery is also a treatment option in severe cases of CDI. The World Society of Emergency Surgery guidelines for management of CDI in surgical patients were published in 2015.
View Article and Find Full Text PDFWorld J Emerg Surg
March 2021
Department of Emergency and Trauma Surgery, Parma University Hospital, Parma, Italy.
Background: Since the COVID-19 pandemic has occurred, nations showed their unpreparedness to deal with a mass casualty incident of this proportion and severity, which resulted in a tremendous number of deaths even among healthcare workers. The World Society of Emergency Surgery conceived this position paper with the purpose of providing evidence-based recommendations for the management of emergency surgical patients under COVID-19 pandemic for the safety of the patient and healthcare workers.
Method: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) through the MEDLINE (PubMed), Embase and SCOPUS databases.
World J Emerg Surg
March 2021
Department of Emergency and Trauma Surgery, University Hospital of Parma, Parma, Italy.
We present the New Year letter from the WSES board to wish everyone a new year full of positive surprises and good news, despite COVID-19 pandemic.We confirm the WSES primary aim: to promote education in emergency surgery putting together all the world experts on emergency surgery without restrictions or boundaries, in inclusivity, equality, and equal opportunities. This will be the year of innovations and WSES will assess the application of artificial intelligence technologies in emergency and trauma surgery.
View Article and Find Full Text PDFSurg Obes Relat Dis
May 2021
Ethicon Inc., Minnetonka, Minnesota. Electronic address:
Background: The long-term safety results of the REALIZE (Ethicon Endo-Surgery, Inc., Cincinnati, OH) adjustable gastric band collected in this prospective, multicenter study in patients with morbid obesity are presented.
Objectives: To determine the reoperation rate, including band revisions, replacements, and explants, resulting from a serious adverse device-related event through years 4 and 5.
BMC Ophthalmol
February 2021
Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Background: To observe the characteristics of binocular integration and stereopsis in children with television torticollis.
Methods: A retrospective study was carried out, where data were collected from 25 children with television torticollis as the disease group after refractive error correction and 25 normal children as the control group. A virtual reality system was used to assess and analyze the characteristics of binocular integration by a contrast balance test and binocular stereopsis.
World J Emerg Surg
February 2021
Emergency and Trauma Surgery, Parma University Hospital, Parma, Italy.
Introduction: Quality in medical care must be measured in order to be improved. Trauma management is part of health care, and by definition, it must be checked constantly. The only way to measure quality and outcomes is to systematically accrue data and analyze them.
View Article and Find Full Text PDFCureus
January 2021
Dermatology, San Diego Family Dermatology, National City, USA.
Basal cell carcinoma is the most common cutaneous neoplasm. Calcinosis cutis is the deposition of calcium within the dermis. An 80-year-old man presented with a pearly nodule on his left nasal ala; a shave biopsy confirmed the diagnosis of a nodular basal cell carcinoma with calcinosis cutis, which was removed with Mohs micrographic surgery.
View Article and Find Full Text PDFWorld Neurosurg
April 2021
Department of Neurosurgery University of California, San Francisco, San Francisco, California, USA.
Background: Spinopelvic parameters have hitherto dictated much of adult spinal deformity (ASD) correction. The Roussouly classification is used for the normal adult spine. We evaluated whether a correlation would be found between the Roussouly type and the rate of revision surgery in patients with ASD undergoing circumferential minimally invasive spinal (cMIS) correction.
View Article and Find Full Text PDFCyberpsychol Behav Soc Netw
December 2020
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.
The aim of this study was to investigate perceptual eye position (PEP) and to evaluate the effect of dichoptic visual perceptual training in postoperative intermittent exotropia [X(T)]. We enrolled 30 non-strabismus children (control group) and 54 postoperative X(T) children [divided into training group (33 patients) and non-training group (21 patients)]. All subjects received measurements of PEP, and the postoperative X(T) children were measured both in the third postoperative day and the third postoperative month.
View Article and Find Full Text PDFBMC Ophthalmol
December 2020
Eye Clinics, Captain James A. Lovell Federal Health Care Center, North Chicago, IL, USA.
Background: Offspring of parent(s) with age-related macular degeneration (AMD) have a 45% lifetime risk of developing the disease. High foveal macular pigment optical density (MPOD) is protective, whereas individuals with a "foveal macular pigment dip" (FMPD) are at increased risk. Shortage of the dietary carotenoids lutein, zeaxanthin as well as fish consumption are reported AMD risk factors.
View Article and Find Full Text PDFJ Trauma Acute Care Surg
December 2020
From the Division of Trauma (L.K., J.S.), Surgical Critical Care, Burns, and Acute Care Surgery, University of California San Diego, San Diego; Comparative Effectiveness and Clinical Outcomes Research Center (R.C.), Riverside University Health System Medical Center, Loma Linda University School of Medicine, Riverside, California; Vascular and Trauma Surgery (A.M.O.G. Jr.), Universidade Federal do Pará/Centro Universitário do Estado do Pará, Belém, PA, Brazil; Department of War Surgery (V.R.), Kirov Military Medical Academy, Saint Petersburg, Russia; Department of Surgery (E.E.M.), Ernest E. Moore Shock Trauma Center at Denver Health, University of Colorado, Denver, Colorado; Division Chief Trauma and Acute Care Surgery (J.M.G.), Department of Surgery, University of California Davis, Sacramento, California; Department of Surgery, College of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates; Division of Trauma and Acute Care Surgery, Department of Surgery (A.B.P.), University of Pittsburgh School of Medicine, Pittsburg, Pennsylvania; Division of Trauma and Acute Care Surgery, Department of Surgery (C.A.O.), Fundación Valle del Lili, Universidad del Valle, Cali, Colombia; Department of Surgery (R.V.M.), University of Washington, Seattle, Washington; Department of Surgery (S.D.S.), University Hospital of Varese, University of Insubria, Italy; Division of Acute Care Surgery, Department of Surgery (R.I.), Virginia Commonwealth University Richmond, Virginia; Unit of Digestive and HPB Surgery (N.D.A.), CARE Department, Henri Mondor University Hospital (AP-HP) and Faculty of Medicine, University of Paris Est, UPEC, Creteil, France; R. Adams Cowley Shock Trauma Center (T.S.), University of Maryland, Baltimore, Maryland; Emergency Surgery Department (F.C.), Parma University Hospital, Parma, Italy; Department of Surgery and Critical Care Medicine (A.K.), University of Calgary, Calgary, Alberta, Canada; Department of Emergency Surgery (V.K.), City Hospital, Mozyr, Belarus; Departments of Surgery and Medicine (N.P.), Schulich School of Medicine and Dentistry, Western University London Health Sciences Centre, London, Ontario, Canada; Trauma Services (I.C.), Auckland City Hospital, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; Abdominal Center, Department of Surgery (A.L., M.S.), University Hospital Meilahti, Helsinki, Finland; Department of Digestive Surgery (M. Chirica), Grenoble University Hospital, Grenoble, France; 3rd Department of Surgery (E.P.), Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece; Division of Trauma/Acute Care Surgery and Surgical Critical Care (G.P.F.), University of Campinas, Campinas, Brazil; General, Emergency Surgery, and Trauma Center (M. Chiarugi), University of Pisa, Pisa, Italy; Department of General and Upper GI Surgery (D.D.), Royal Infirmary of Edinburgh, Edinburgh, United Kingdom; Dipartimento di Scienze Clinico Chirurgiche (E.C.), Diagnostiche e Pediatriche, University of Pavia, Pavia; General and Emergency Surgery Department (M. Ceresoli), School of Medicine and Surgery, Milano-Bicocca University, Monza, Italy; Service de Chirurgie Generale, Digestive, Metabolique Centre Hospitalier de Poissy (B.D.S.), St Germain en Laye, France; Departamento de Cirugía (F.V.-R.), Hospital Angeles Lomas, Curso Universitario Posgrado de Cirugía, Universidad Nacional Autónoma de México, Mexico, Mexico; Department of Surgery (M.S.), Macerata Hospital (ASUR Marche), Macerata, Italy; Trauma Surgery Department (W.B.), Scripps Memorial Hospital, La Jolla, California; General Surgery Department (L.A.), Bufalini Hospital, Cesena, Italy; and Trauma Service, Department of General Surgery (D.G.W.), Royal Perth Hospital, The University of Western Australia, Perth, Australia.
Abdominal vascular trauma accounts for a small percentage of military and a moderate percentage of civilian trauma, affecting all age ranges and impacting young adult men most frequently. Penetrating causes are more frequent than blunt in adults, while blunt mechanisms are more common among pediatric populations. High rates of associated injuries, bleeding, and hemorrhagic shock ensure that, despite advances in both diagnostic and therapeutic technologies, immediate open surgical repair remains the mainstay of treatment for traumatic abdominal vascular injuries.
View Article and Find Full Text PDFJ Trauma Acute Care Surg
December 2020
From the Division of Trauma (L.K., J.S.), Surgical Critical Care, Burns, and Acute Care Surgery, University of California San Diego, San Diego, California; Comparative Effectiveness and Clinical Outcomes Research Center (R.C.), Riverside University Health System Medical Center, Loma Linda University School of Medicine, Riverside, California; Vascular and Trauma Surgery (A.M.O.G. Jr.), Universidade Federal do Pará/Centro Universitário do Estado do Pará, Belém, PA, Brazil; Department of War Surgery (V.R.), Kirov Military Medical Academy, Saint Petersburg, Russia; Department of Surgery (E.E.M.), Ernest E. Moore Shock Trauma Center at Denver Health, University of Colorado, Denver, Colorado; Division Chief Trauma and Acute Care Surgery (J.G.), Department of Surgery. University of California Davis, Sacramento, California; Department of Surgery (F.A.-Z.), College of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates; Division of Trauma and Acute Care Surgery, Department of Surgery (A.B.P.), University of Pittsburgh School of Medicine, Pittsburg, Pennsylvania; Division of Trauma and Acute Care Surgery, Department of Surgery (C.O.), Fundación Valle del Lili, Universidad del Valle, Cali, Colombia; Department of Surgery (R.V.M.), University of Washington, Seattle, Washington; Department of Surgery (S.D.S.), University Hospital of Varese, University of Insubria, Varese, Italy; Division of Acute Care Surgery, Department of Surgery (R.I.), Virginia Commonwealth University Richmond, Virginia; Unit of Digestive and HPB Surgery (N.D.A.), CARE Department, Henri Mondor University Hospital (AP-HP) and Faculty of Medicine, University of Paris Est, UPEC, Creteil, France; R. Adams Cowley Shock Trauma Center (T.S.), University of Maryland, Baltimore, Maryland; Emergency Surgery Department (F.C.), Parma University Hospital, Parma, Italy; Department of Surgery and Critical Care Medicine (A.K.), University of Calgary, Calgary, Alberta, Canada; Department of Emergency Surgery (V.K.), City Hospital, Mozyr, Belarus; Departments of Surgery and Medicine (N.P.), Schulich School of Medicine and Dentistry, Western University London Health Sciences Centre, London, Ontario, Canada; Trauma Services (I.C.), Auckland City Hospital, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; Abdominal Center, Department of Surgery (A.L.), University Hospital Meilahti, Helsinki, Finland; Department of Digestive Surgery (M. Chirica), Grenoble University Hospital, Grenoble, France; 3rd Department of Surgery (E.P.), Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece; Division of Trauma/Acute Care Surgery and Surgical Critical Care (G.P.F.), University of Campinas, Campinas, Brazil; General, Emergency Surgery, and Trauma Center (M. Chiarugi, F.C.), University of Pisa, Pisa, Italy; Department of General and Upper GI Surgery (D.D.), Royal Infirmary of Edinburgh, Edinburgh, United Kingdom; Dipartimento di Scienze Clinico Chirurgiche (E.C.), Diagnostiche e Pediatriche, University of Pavia, Pavia; General and Emergency Surgery Department (M. Ceresoli), School of Medicine and Surgery, Milano-Bicocca University, Monza, Italy; Service de Chirurgie Generale, Digestive, Metabolique Centre Hospitalier de Poissy (B.D.S.), St Germain en Laye, France; Universidad Nacional Autónoma de México, Curso Universitario Posgrado de Cirugía, Departamento de Cirugía (F.V.-R.), Hospital Angeles Lomas, Mexico, Mexico; Department of Surgery (M.S.), Macerata Hospital (ASUR Marche), Macerata, Italy; Trauma Surgery Department (W.B.), Scripps Memorial Hospital, La Jolla, California; General Surgery Department (L.A.), Bufalini Hospital, Cesena, Italy; and Trauma Service, Department of General Surgery (D.G.W.), Royal Perth Hospital, The University of Western Australia, Perth, Australia.
The peripheral arteries and veins of the extremities are among the most commonly injured vessels in both civilian and military vascular trauma. Blunt causes are more frequent than penetrating except during military conflicts and in certain geographic areas. Physical examination and simple bedside investigations of pulse pressures are key in early identification of these injuries.
View Article and Find Full Text PDFCrit Care Explor
November 2020
Department of Pharmaceutical Services, University of California, San Francisco Medical Center, San Francisco, CA.
Objectives: Prolonged use of dexmedetomidine has become increasingly common due to its favorable sedative and anxiolytic properties. Hypersympathetic withdrawal symptoms have been reported with abrupt discontinuation of prolonged dexmedetomidine infusions. Clonidine has been used to transition patients off dexmedetomidine infusions for ICU sedation.
View Article and Find Full Text PDFWorld J Emerg Surg
November 2020
General and Emergency Surgery, Bufalini Hospital, Cesena, Italy.
Background: Acute calculus cholecystitis (ACC) has a high incidence in the general population. The presence of several areas of uncertainty, along with the availability of new evidence, prompted the current update of the 2016 WSES (World Society of Emergency Surgery) Guidelines on ACC.
Materials And Methods: The WSES president appointed four members as a scientific secretariat, four members as an organization committee and four members as a scientific committee, choosing them from the expert affiliates of WSES.
J Trauma Acute Care Surg
November 2020
From the Departments of Surgery (A.L.D., B.H.M., E.A.R., E.D., D.H.F., S.E.R., M.A.S., M.F.) and Emergency Medicine (J. Jui), Oregon Health and Science University, Portland, Oregon; Departments of Emergency Medicine (J.M.) and Surgery (J. Johannigman), University of Cincinnati, Cincinnati, Ohio; Departments of Surgery (B.R.H.R., E.M.B., P.K.) and Biostatistics (D.K., B.M., E.N.M., S.M., K.S., J.H.), University of Washington, Seattle, Washington; Trauma Surgery (B.T.), Texas Health Presbyterian Hospital; Department of Emergency Medicine (J.S.G.), Baylor University Medical Center, Dallas, Texas; Johns Hopkins School of Medicine (M.L.W.), Baltimore, Maryland; Department of Emergency Medicine (T.P.A., M.R.C.), Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Emergency Medicine (J.M.T., J.C.), University of British Columbia, Vancouver, British Columbia, Canada; Department of Surgery (S.E.R.), Scripps Memorial Hospital La Jolla, La Jolla, California; Departments of Emergency Medicine (A.H.I.) and Internal Medicine (A.H.I.), University of Texas Southwestern Medical Center, Dallas, Texas; Providence Health Care Research Institute (J.C.), Vancouver, British Columbia, Canada; Rescu, Li Ka Shing Knowledge Institute (L.J.M.), and Department of Surgery (S.R.), St. Michael's Hospital; Division of Emergency Medicine, Department of Medicine Faculty of Medicine (L.J.M.), and Department of Laboratory Medicine and Pathobiology (J.C.), University of Toronto, Toronto, Ontario, Canada; Departments of Emergency Medicine (R.J.F.) and Surgery (D.J.D.), Regions Hospital, St. Paul, Minnesota; Department of Surgery (C.W., P.L.B.), University of Alabama, Birmingham, Alabama; Department of Surgery (C.E.W., B.A.C., L.E.V.), McGovern Medical School, University of Texas Health Science Center, Houston, Texas; Department of Laboratory Medicine and Molecular Diagnostics (J.C.), Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Departments of Emergency Medicine (N.J.R.) and Surgery (R.R.G.), John Peter Smith Health Network, Fort Worth, Texas; Department of Surgery (M.D.Z., M.F.), Mayo Clinic, Rochester, Minnesota; British Columbia Emergency Health Services (J.M.T., R.S.), Vancouver, British Columbia, Canada; Department of Emergency Medicine (L.K., A.H.), Hennepin County Medical Center, Minneapolis, Minnesota; Department of Surgery (S.R.), St. Michael's Hospital, Toronto, Ontario, Canada; Department of Emergency Medicine (M.G.), Medical City Plano, Plano; Emergency Medicine (R.S.), Methodist Dallas Medical Center, Dallas, Texas; National Heart, Lung, and Blood Institute, National Institutes of Health (G.S.), Bethesda, Maryland; and Department of Trauma Surgery (W.W.), Texas Health Harris Methodist Hospital, Fort Worth, Texas.
Background: No Food and Drug Administration-approved medication improves outcomes following traumatic brain injury (TBI). A forthcoming clinical trial that evaluated the effects of two prehospital tranexamic acid (TXA) dosing strategies compared with placebo demonstrated no differences in thromboelastography (TEG) values. We proposed to explore the impact of TXA on markers of coagulation and fibrinolysis in patients with moderate to severe TBI.
View Article and Find Full Text PDFDermatol Surg
October 2020
Cosmetic Laser Dermatology, Scripps Memorial Hospital La Jolla, San Diego, California.
Cardiovasc Digit Health J
August 2020
Division of Cardiology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.
Background: Many digital health technologies capable of atrial fibrillation (AF) detection are directly available to patients. However, adaptation into clinical practice by heart rhythm healthcare practitioners (HCPs) is unclear.
Objective: To examine HCP perspectives on use of commercial technologies for AF detection and management.
Cureus
August 2020
Dermatology/Dermatopathology, Compass Dermatopathology, San Diego, USA.
Sarcoptes scabiei classically presents with pruritic burrows. In addition to finger and toe web lesions, the penis and scrotum of men, the breast and areola of women, and the buttocks and axillae of both gender are common locations for mite-associated lesions. Scabies surrepticius refers to mite-related lesions that are not classical in morphology and/or distribution; there are several subtypes of non-classic or atypical scabies.
View Article and Find Full Text PDFAm J Phys Med Rehabil
January 2021
From the Moss Rehabilitation Research Institute, Einstein Healthcare Network, Elkins Park, Pennsylvania (JW, MF); Department of Physical Medicine and Rehabilitation, Wayne State University, Detroit, Michigan (MPD); MGH Institute of Health Professions, Boston, Massachusetts (SEF, JHVS); Department of Occupational Therapy, Spaulding Rehabilitation Hospital, and Sargent College of Health and Rehabilitation Sciences, Department of Occupational Therapy, Boston University, Boston, Massachusetts (LWK); Department of Neurological Rehabilitation, Scripps Memorial Hospital, Encinitas, California (SN); Department of Physical Therapy, University of Alberta, Edmonton, AB, Canada (EP); Department of Physical Medicine and Rehabilitation, Carolinas Rehabilitation, Charlotte, North Carolina (SMP); School of Public Health and Health Professions, Department of Rehabilitation Science, University at Buffalo, Buffalo, New York (SAS); Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts (JHVS); and School of Health and Rehabilitation Sciences, Division of Occupational Therapy, The Ohio State University, Columbus, Ohio (LW).
Clear reporting on rehabilitation treatments is critical for interpreting and replicating study results and for translating treatment research into clinical practice. This article reports the recommendations of a working group on improved reporting on rehabilitation treatments. These recommendations are intended to be combined with the efforts of other working groups, through a consensus process, to arrive at a reporting guideline for randomized controlled trials in physical medicine and rehabilitation (Randomized Controlled Trials Rehabilitation Checklist).
View Article and Find Full Text PDFCureus
June 2020
Dermatology, San Diego Family Dermatology, National City, USA.
Tinea is a superficial fungal infection of the skin. Gyrate erythemas are reactive conditions that present as annular red lesions. A 61-year-old woman was diagnosed with tinea corporis whose skin lesions morphologically mimicked a gyrate erythema.
View Article and Find Full Text PDFJ Neurosurg Spine
December 2020
1Department of Neurosurgery, University of California, Los Angeles.
Cervical spondylosis is one of the most commonly treated conditions in neurosurgery. Increasingly, cervical disc replacement (CDR) has become an alternative to traditional arthrodesis, particularly when treating younger patients. Thus, surgeons continue to gain a greater understanding of short- and long-term complications of arthroplasty.
View Article and Find Full Text PDFInj Epidemiol
July 2020
Trauma Service, Scripps Memorial Hospital La Jolla, 9888 Genesee Ave., LJ601, La Jolla, CA, 92037, USA.