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Objective: To evaluate the effects of topical emollient therapy on fluid intake, urine output, serum electrolytes, glucose, bilirubin and other outcome measures of neonates < or = 27 weeks' gestational age (GA) with birthweight (BW) <1,000 g.

Methods: We reviewed medical records of 18 infants treated with topical emollient Aquaphor, and 36 BW- and GA-matched control infants that were not treated with similar topical emollient.

Results: Characteristics of the study and control infants were similar: BW: 698 +/- 144 g vs.

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