4 results match your criteria: "Scientific Institute for Hospitalization and Care (IRCCS)[Affiliation]"

Therapeutic hypothermia (TH) is the standard of care for newborns with moderate to severe hypoxic-ischemic encephalopathy (HIE). Discomfort and pain during treatment are common and may affect the therapeutic efficacy of TH. Opioid sedation and analgesia (SA) are generally used in clinical practice, and fentanyl is one of the most frequently administered drugs.

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Background: The aim of the present study was to examine the short-term changes in body composition and physical capabilities in subjects with obesity during a multidisciplinary inpatient body weight reduction program (BWRP).

Methods: One hundred thirty-nine adolescents (56 boys and 83 girls; BMI: 37.1 ± 6.

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Article Synopsis
  • Podocyte dysfunction and loss significantly contribute to proteinuria and FSGS, a common cause of this condition, yet the mechanisms behind podocyte injury and protection are not well understood.
  • The study found that podocytes can create tunneling nanotubes (TNTs) dependent on the protein M-Sec, which is involved in cell communication and protection against injury.
  • Results showed that M-Sec is overexpressed in FSGS, and its deletion led to podocyte damage and mitochondrial issues; restoring M-Sec improved podocyte function, suggesting it could be a potential therapeutic target for FSGS.
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