3 results match your criteria: "Scientific Institute Vita-Salute University San Raffaele[Affiliation]"

TMS of primary motor cortex with a biphasic pulse activates two independent sets of excitable neurones.

Brain Stimul

February 2019

Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom. Electronic address:

Background: Biphasic pulses produced by most commercially available TMS machines have a cosine waveform, which makes it difficult to study the interaction between the two phases of stimulation.

Objective: We used a controllable pulse TMS (cTMS) device delivering quasi-rectangular pulse outputs to investigate whether monophasic are more effective than biphasic pulses.

Methods: Temporally symmetric ("biphasic") or highly asymmetric ("monophasic") charge-balanced biphasic stimuli were used to target the hand area of motor cortex in the anterior-posterior (AP) or posterior-anterior (PA) initial current direction.

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Article Synopsis
  • Walking rehabilitation is crucial for stroke survivors due to its significant impact on recovery and daily life activities, with many still facing gait impairments despite a majority being able to walk.
  • Various brain regions involved in walking can be targeted using noninvasive brain stimulation (NIBS) techniques, which promote neuroplasticity by modulating neural activity.
  • Recent studies highlight the potential of NIBS not only for improving functions like hand movement and cognitive deficits but also for addressing gait disturbances in stroke recovery.
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Deep repetitive transcranial magnetic stimulation with H-coil on lower limb motor function in chronic stroke: a pilot study.

Arch Phys Med Rehabil

June 2014

Scientific Institute Vita-Salute University San Raffaele, Neurological Department, Experimental Neurophysiology Unit, INSPE-Institute of Experimental Neurology, Milan, Italy. Electronic address:

Objectives: To assess the efficacy of high-frequency (20 Hz) brain stimulation on lower limb motor function in subjects with chronic (> 6 mo) subcortical stroke.

Design: Double-blind, placebo-controlled crossover study.

Setting: University hospital.

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