2 results match your criteria: "Scientific Institute OSR[Affiliation]"

Magnetic-field-driven targeting of exosomes modulates immune and metabolic changes in dystrophic muscle.

Nat Nanotechnol

October 2024

Stem Cell Laboratory, Dino Ferrari Center, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

Article Synopsis
  • Exosomes have potential as treatments for tissue repair and boosting immune responses, especially in conditions like muscular dystrophy, but targeting them effectively in the body is challenging.
  • This study introduces a new delivery system that uses ferromagnetic nanotubes to control where exosomes go in the body, specifically targeting skeletal muscles through an external magnetic field.
  • Results showed that macrophages effectively take up these exosomes, enhancing muscle repair in a mouse model of Duchenne muscular dystrophy, paving the way for improved exosome-based therapies.
View Article and Find Full Text PDF