2 results match your criteria: "Scientific Institute Fondazione Don Gnocchi[Affiliation]"
Relationship between damage to the cerebellar peduncles and clinical disability in multiple sclerosis.
Radiology
June 2014
From the Neuroimaging Research Unit (P.P., M.A.R., E.P., M.F.) and Department of Neurology (P.P., M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Clinics of Neurology (S.M., J. Drulovic, J. Dackovic) and Radiology (T.S.O.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Biostatistics Unit, IRCCS-Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy (M.C.); and Department of Neurology, Scientific Institute Fondazione Don Gnocchi, Milan, Italy (D.C.).
Purpose: To assess whether a structural disconnection between the cerebellum and the cerebral hemispheres contributes to cerebellar and brainstem symptoms in multiple sclerosis (MS).
Materials And Methods: This study was approved by the local ethics committee, and written informed consent was obtained from each participant. Brain T2 lesion load, cerebellar white matter and gray matter volumes, and tract-specific measures of the middle and superior cerebellar peduncles were derived from 172 patients with MS and 46 control subjects.
Diffusion anisotropy of the cervical cord is strictly associated with disability in amyotrophic lateral sclerosis.
J Neurol Neurosurg Psychiatry
May 2007
MRI Research Group, Scientific Institute Fondazione Don Gnocchi, Via Capecelatro 66, 20148 Milan, Italy.
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with severe cervical cord damage due to degeneration of the corticospinal tracts and loss of lower motor neurones. Diffusion tensor magnetic resonance imaging (DT MRI) allows the measurement of quantities reflecting the size (such as mean diffusivity) and orientation (such as fractional anisotropy) of water-filled spaces in biological tissues.
Methods: Mean diffusivity and fractional anisotropy histograms from the cervical cord of patients with ALS were obtained to: (1) quantify the extent of tissue damage in this critical central nervous system region; and (2) investigate the magnitude of the correlation of cervical cord DT MRI metrics with patients' disability and tissue damage along the brain portion of the corticospinal tracts.