SUPEROXIDE DISMUTASE (SOD2) GENE VAL16ALA POLYMORPHISM AND CHANGES IN THE VENTILATION LUNG CAPACITY OF CHILDREN - RESIDENTS OF RADIOACTIVELY CONTAMINATED TERRITORIES AND CHILDREN WHO HAVE BEEN AFFECTED BY STRESSFUL LIFE EVENTS DURING WARTIME.

Objective: to determine the distribution of genotypes of genetic polymorphism of manganese superoxide dismutaseand to assess the ventilation lung capacity in children- residents of radioactively contaminated areas and childrenexposed to stressful life events during the war period.

Materials And Methods: The study involved school-age children - residents of radioactively contaminated areas(RCA) and children exposed to stressful life events during wartime. All those examined had no clinical signs of respiratory pathology.

LEVELS AND RELATIVE RISKS OF MORTALITY OF CHORNOBYL CLEAN-UP WORKERS IN 1986-1987 YEARS FROM MAIN NON-NEOPLASTIC DISEASES (OBSERVATION PERIOD 1988-2021).

Unlabelled: The emergency destruction of the 4th reactor of the Chornobyl nuclear power plant necessitated large-scale emergency work, which involved large contingents of specialists. Analysis the mortality of Chornobyl clean-up workers isan important and relevant basis for planning medical protection measures in conditions of a potential threat ofemergency and other radiation situations.The objective of this work is to determine the levels and relative risks of mortality of Chornobyl clean-up workers in1986-1987 years from major non-tumor diseases depending on the received dose of radiation exposure, taking intoaccount age and time after the accident (period of epidemiological studies 1988-2021).

Second primary malignancies in patients with papillary thyroid carcinoma after effect of post-chernobyl irradiation: A risk analysis of more than two decades of observations.

Background: Second primary malignancy in patients with papillary thyroid carcinoma after Chernobyl accident is an emerging problem. The aims of the study are to investigate the rates and distribution of second primary malignant tumours in Belarus survivors of post-Chernobyl papillary thyroid carcinoma and the cumulative rate of developing a second primary malignancy in a group of patients with metachronous second primaries.

Methods: Patients aged 18 or younger at the time of Chernobyl accident who were diagnosed with papillary thyroid carcinoma after 1986 were identified from the Belarus Cancer Registry.

Expression of Ki-67 and CD34 on blood and bone marrow cells of CML patients with different response to imatinib and nilotinib therapy.

Aim: To assess the expression of Ki-67 protein and CD34 antigen on peripheral blood (PB) and bone marrow (BM) cells in chronic myelogenous leukemia (CML) patients with different response to tyrosine kinase inhibitors (TKI) imatinib (IM) and nilotinib (NI) therapy.

Patients And Methods: BM aspirate and PB samples from 41 CML patients treated with IM and NI were studied by cytogenetic, molecular genetic, and flow cytometry methods. According to the response to TKIs, the patients were distributed into the optimal response, warning, and treatment failure groups.

[Transperineal ultrasound imaging of the internal pudendal artery in arteriogenic erectile dysfunction].

Aim: To determine the practical and diagnostic value of transperineal ultrasound imaging of the internal pudendal artery (IPA) in patients with arteriogenic erectile dysfunction (ED).

Materials And Methods: Transperineal IPA and penile Doppler ultrasonography was performed in 50 healthy young male volunteers aged 23.6+/-3.

Exposure from the Chernobyl accident had adverse effects on erythrocytes, leukocytes, and, platelets in children in the Narodichesky region, Ukraine: a 6-year follow-up study.

Background: After the Chernobyl nuclear accident on April 26, 1986, all children in the contaminated territory of the Narodichesky region, Zhitomir Oblast, Ukraine, were obliged to participate in a yearly medical examination. We present the results from these examinations for the years 1993 to 1998. Since the hematopoietic system is an important target, we investigated the association between residential soil density of 137Caesium (137Cs) and hemoglobin concentration, and erythrocyte, platelet, and leukocyte counts in 1,251 children, using 4,989 repeated measurements taken from 1993 to 1998.

Worker health and safety issues in reinforcing the entombment of the Chernobyl reactor.

The paper provides an overview of current work involving the strengthening of the Sarcophagus over the Chernobyl Nuclear Power Plant destroyed 4th unit. It includes a brief summary of the types of work being performed, the radiological environment, the medical surveillance program, the protective measures being implemented, and the internal and external radiation monitoring program for the workers. Also, it presents a summary of the workplace monitoring data and the internal and external dosimetry data, and estimates of the total effective doses received by the workers during the work.

Physical dosimetry of chernobyl cleanup workers.

This paper presents a critical review of dosimetric monitoring practices during Chernobyl cleanup from 1986 to 1990. Dosimetric monitoring is considered in time evolution with respect to legislative background (including dose limits), methods of dose assessment, and coverage of workers with radiation monitoring programs as well as availability of data on individual doses of liquidators. Four large independent dosimetry services (Administration of Construction No.

Dosimetry for a study of low-dose radiation cataracts among Chernobyl clean-up workers.

A cohort of 8,607 Ukrainian Chernobyl clean-up workers during 1986-1987 was formed to study cataract formation after ionizing radiation exposure. Study eligibility required the availability of sufficient exposure information to permit the reconstruction of doses to the lens of the eye. Eligible groups included civilian workers, such as those who built the "sarcophagus" over the reactor, Chernobyl Nuclear Power Plant Workers, and military reservists who were conscripted for clean-up work.

Reconstruction of (131)I radioactive contamination in Ukraine caused by the Chernobyl accident using atmospheric transport modelling.

The evaluation of (131)I air and ground contamination field formation in the territory of Ukraine was made using the model of atmospheric transport LEDI (Lagrangian-Eulerian DIffusion model). The (131)I atmospheric transport over the territory of Ukraine was simulated during the first 12 days after the accident (from 26 April to 7 May 1986) using real aerological information and rain measurement network data. The airborne (131)I concentration and ground deposition fields were calculated as the database for subsequent thyroid dose reconstruction for inhabitants of radioactive contaminated regions.

Post-Chornobyl thyroid cancers in Ukraine. Report 1: estimation of thyroid doses.

About 1.8 EBq of 131I was released into the atmosphere during the Chornobyl accident that occurred in Ukraine on April 26, 1986. More than 10% of this activity was deposited on the territory of Ukraine.

Mesoscale modelling of radioactive contamination formation in Ukraine caused by the Chernobyl accident.

This work is devoted to the reconstruction of time-dependent radioactive contamination fields in the territory of Ukraine in the initial period of the Chernobyl accident using the model of atmospheric transport LEDI (Lagrangian-Eulerian DIffusion model). The modelling results were compared with available 137Cs air and ground contamination measurement data. The 137Cs atmospheric transport over the territory of Ukraine was simulated during the first 12 days after the accident (from 26 April to 7 May 1986) using real aerological information and rain measurement network data.

EEG patterns in persons exposed to ionizing radiation as a result of the chernobyl accident. Part 2: quantitative EEG analysis in patients who had acute radiation sickness.

Cross-sectional quantitative electroencephalogram (qEEG) study (1996-2001) among Chernobyl accident survivors, who had confirmed acute radiation sickness and were irradiated in dose of 1-5 Gy, revealed the neurophysiological markers of ionizing radiation. Neuropsychological markers were: left fronto-temporal dominant frequency reduction; absolute delta-power lateralization to the left (dominant) hemisphere; relative delta-power increase in the fronto-temporal areas; absolute theta-power decrease in the left temporal region; absolute and relative alpha-power diffusive decrease, which may reflect cortico-limbic dysfunction lateralized to the left, dominant hemisphere, with the fronto-temporal cortical and hippocampal damage. Quantitative electroencephalogram proposed for differentiation of radiation and nonradiation brain damages and as a new biological dosymetry method.

[Long-term cytogenetic effects in children prenatally-exposed to radiation as a result of the accident at the Chernobyl Atomic Energy Station].

Forty-two children exposed to ionizing radiation in prenatal period and 15 children of control group were examined in the remote terms after the accident using the method of differential G-staining of chromosomes in lymphocytes of peripheral blood. It was found that the average group rate of aberrant cells and chromosome aberrations was reliably higher in the children exposed in utero compared to control. Long-term cytogenetic consequences of the pre-natal exposure were characterized by prevalence of aberrations of a chromosome type, mainly stable chromosome lesions.

[Metabolic activity of blood and bone marrow cells after exposure to low dose ionizing radiation].

The processes of heat production in blood and bone marrow cells by method of microcalorimetry in the experiments on the rats in different terms after radiation influence were study. The irradiation of animals led to some increase of power heat energy production in bone marrow cells. The changes of heat processes in blood and bone marrow cells during month after irradiation were established.

Schizophrenia spectrum disorders in persons exposed to ionizing radiation as a result of the Chernobyl accident.

We studied schizophrenia spectrum disorders in Chernobyl accident survivors by analyzing Chernobyl exclusion zone (EZ) archives (1986-1997) and by conducting a psychophysiological examination of 100 patients with acute radiation sickness (ARS) and 100 workers of the Chernobyl EZ who had worked as "liquidators-volunteers" for 5 or more years since 1986-1987. Beginning in 1990, there has been a significant increase in the incidence of schizophrenia in EZ personnel in comparison to the general population (5.4 per 10,000 in the EZ versus 1.

[Efficacy of antioxidant preparations used for correction of impairment of oxidative homeostasis in Chernobyl liquidators].

The influence of two antioxidative preparations (Vetoron, Morevit) on the parameters of antioxidative system and lipoperoxidative processes in blood of men, who took part in the cleaning up after Chernobyl NPP accident, under the clinical control in the hospital of Scientific Center for Radiation Medicine AMS of Ukraine was studied. It was shown that Morevit (extract of protein-hydrocarboneus concentrate of Mytilis galloprovincialis) is more effective as promoter of normalization lipoperoxidative processes disorders and restoration of antioxidative enzymes activity. The main principles of antioxidative therapy were formulated.

Effective doses due to external irradiation from the Chernobyl accident for different population groups of Ukraine.

A model for the external exposure of the Ukrainian population after the Chernobyl accident was developed. It is based on extensive measurements of external gamma-exposure rates (EGER) in air and of external effective doses of members of five population groups. Questionnaires were used to determine the occupancy times of members of the population groups at three types of locations; inside houses, outdoors, and outside of the home settlement.

Evaluation of the 131I thyroid-monitoring measurements performed in Ukraine during May and June of 1986.

After the Chernobyl accident in 1986, about 150,000 monitoring measurements were performed in Ukraine. From this data base, 40,000 measurements were selected for which the results of the reference-source measurements could be analyzed by statistical means. The majority of these measurements are of high quality.