27 results match your criteria: "Scientific Center for Anti-Infectious Drugs[Affiliation]"

Antibacterial coatings on model silicon wafers and implants, based on chitosan (CHI), poly(acrylic acid) (PAA), and the antibacterial agent chlorhexidine digluconate (CHX), were obtained using a layer-by-layer assembly method. The surface roughness and 2D and 3D images of the surfaces of CHI/PAA/CHX coatings obtained from different pH assemblies were investigated by atomic force microscopy, revealing that pH 6 enabled optimal inclusion of CHX in the multilayer film. The structure and elemental composition before and after implementation of CHX into the coating were investigated via scanning electron microscopy and energy-dispersive X-ray spectroscopy.

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Biological effects and phytochemical study of the underground part of Iris scariosa Willd. ex Link extract: A new source of bioactive constituents.

Fitoterapia

June 2024

Asfendiyarov Kazakh National Medical University, Tole Bi St. 94, Almaty 050000, Republic of Kazakhstan; Higher School of Medicine, Al-Farabi Kazakh National University, 71 al-Farabi Ave., Almaty 050040, Republic of Kazakhstan.

The expected toxicity and resistance of chemotherapeutic agents necessitate and encourage for the use of natural chemotherapeutic sources of plant origin in the clinical stage of cancer therapy. Plants of the genus Iris (Iridaceae) used by local populations for the treatment of cancer, bacterial and viral infections. In this study, an ethanol extract of rhizomes of I.

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Unlabelled: 1.

Background: Iodine is a broad-spectrum antimicrobial disinfectant for topical application. Recent studies have shown promising results on the applicability of an iodine-containing complex, FS-1, against antibiotic-resistant pathogens.

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The aim of this study was to evaluate phagocytic and oxidative activities of monocytes and granulocytes during combined therapy of mice infected by drug-resistant SCAID OTT1-2022. The treatment of the infected mice was conducted by using an iodine-containing coordination compound CC-195, antibiotic cefazolin and by a combined therapy with CC-195 and cefazolin. The PHAGOTEST and BURSTTEST kits (BD Biosciences, USA) were used to determine the phagocytic and oxidative activities.

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The article presents parameters for obtaining a carbon dioxide extract from the subterranean part of that contains a valuable set of organic substances and has a certain antimicrobial effect. . Raw materials were collected in the Almaty region (Republic of Kazakhstan).

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The layer-by-layer assembly (LBL) method was used in this work to apply antibacterial coatings to the surface of sutures. The nanofilm was created using sodium carboxymethyl cellulose, chitosan, and chlorhexidine digluconate. Polyethylene terephthalate and polyamide surgical sutures were used as the substrate.

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Hospital-acquired infections are a generally recognized problem for healthcare professionals. Clinical variants of Gram-negative and Gram-positive pathogens are characterized with enhanced antibiotic resistance and virulence due to mutations and the horizontal acquisition of respective genetic determinants. In this study, two , two , three , two , one and one showing broad spectra of antibiotic resistance were isolated from patients suffering from nosocomial infections in a local hospital in Almaty, Kazakhstan.

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The whole genome sequence of a hospital infection agent, SCAID WND1-2022 (370), is reported. Raw PacBio generated reads and the genome sequence were deposited at NCBI under BioProject PRJNA754843. The genome comprises two replicons: 4,880,425 bp long chromosome comprising 4524 proteins and functional RNA coding genes and 38,606 bp long plasmid containing 40 CDS.

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roots are widely used in traditional medicine to treat various diseases throughout the world. In this study, for the first time, we investigated the component composition and biological activity of various extracts from the roots of collected in the highlands of the Kakpakty Mountains of the Almaty region (Republic of Kazakhstan). Extracts were obtained by three different methods: percolation extraction, ultrasound-assisted extraction, and supercritical carbon dioxide extraction.

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CdS nanoparticles were successfully synthesized using cadmium acetate and sodium sulfide as Cd and S precursors, respectively. The effect of using sodium thiosulfate as an additional sulfur precursor was also investigated (combined milling). The samples were characterized by XRD, Raman spectroscopy, XPS, UV-Vis spectroscopy, PL spectroscopy, DLS, and TEM.

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The appearance of drug-resistant pathogens reduces the therapeutic applicability of antibiotics and increases the rate of hospital infections among patients. Complete genome sequences of four Gram-positive clinical isolates of Streptococcus and Staphylococcus were obtained and analyzed to serve as model microorganisms for further studies on drug-induced antibiotic resistance reversion.

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The problem of nosocomial infections is growing due to the introduction of new treatment regimens involving immunosuppressive drugs. The genomes of seven Gram-negative clinical isolates of Escherichia, Klebsiella, and Pseudomonas were sequenced and analyzed in this study to serve as model microorganisms to study drug-induced antibiotic resistance reversion.

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Here, we report the coding-complete genome sequence of a clinical sample of influenza virus obtained from a pig at a livestock farm in Karaganda, Central Kazakhstan, during a pig study in 2020. Isolate A/Swine/Karaganda/04/2020 (H1N1) belongs to clade 1A.3.

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Transcriptomics and methylomics study on the effect of iodine-containing drug FS-1 on ATCC BAA-196.

Future Microbiol

September 2021

Department of Biochemistry, Genetics & Microbiology, Centre for Bioinformatics & Computational Biology, University of Pretoria, Pretoria, South Africa.

Promising results on application of iodine-containing nano-micelles, FS-1, against antibiotic-resistant was demonstrated. RNA sequencing for transcriptomics and the complete genome sequencing by SMRT PacBio were followed by genome assembly and methylomics. FS-1-treated showed an increased susceptibility to antibiotics ampicillin and gentamicin.

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The genus L. from Brassicaceae Burnett. family covers over 150 species with an almost cosmopolitan spread.

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Iodine is one of the oldest antimicrobial agents. Until now, there have been no reports on acquiring resistance to iodine. Recent studies showed promising results on application of iodine-containing nano-micelles, FS-1, against antibiotic-resistant pathogens as a supplement to antibiotic therapy.

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Application of supplementary drugs which increase susceptibility of pathogenic bacteria to antibiotics is a promising yet unexplored approach to overcome the global problem of multidrug-resistant infections. The discovery of a new drug, an iodine-containing nano-molecular complex FS-1, which has proven to improve susceptibility to antibiotics in various pathogens, including MRSA strain ATCC BAA-39, allowed studying this phenomenon. Chromosomal DNA and total RNA samples extracted from the FS-1 treated strain (FS) and from the negative control (NC) cultures were sequenced by PacBio SMRT and Ion Torrent technologies, respectively.

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Complexes of iodine (povidone-iodine and cadexomers) are among the most important antiseptics used in clinical and veterinary medicines. However, high local irritation activity and systemic toxicity limits their oral administration. The purpose of the study was to compare the effect of a new complex of iodine (PA, potentiator of anticancer antibiotics), in which iodine is coordinated by carbohydrates and polypeptides) on the organisms of rats and dogs treated orally with the drug for 30 days.

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Chitosan (CHI) and chitosan/poly(2-ethyl-2-oxazoline) (CHI/POZ)-based films were prepared by casting from aqueous solutions of polymer blends with different compositions. Ciprofloxacin was used as a model drug in these formulations. The weight, thickness, folding endurance and transparency of blend films were measured and characterised.

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The strain ATCC BAA-1790 was sequenced as a model for nosocomial multidrug-resistant infections. Long-read PacBio sequencing revealed a circular chromosome of 3,963,235 bp with two horizontally transferred genomic islands and a 67,023-bp plasmid. Multiple antibiotic resistance genes and genome methylation patterns were identified.

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Here, we report the complete genome sequence of the multidrug-resistant strain ATCC BAA-196, a model organism used for studying possible antibiotic resistance reversion induced by FS-1, an iodine-containing complex. Two genomes, representing FS-1-treated and negative-control variants and composed of a chromosome and several plasmids, were assembled.

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ATCC BAA-39 is the reference organism for a multidrug-resistant (MRSA) strain that was used to study drug-induced resistance reversion by an iodine-containing nanomolecular complex, FS-1. PacBio sequencing was performed on both the experimental and control strains, followed by genome assembly, variant calling, and DNA modification profiling.

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Complete genome sequence of the multidrug-resistant clinical isolate Mycobacterium tuberculosis SCAID 187.0 containing several drug-resistance mutations is presented. This strain is used in experiments to study genomic and population changes leading to reversion of susceptibility to the 1st line anti-tuberculosis (TB) drugs under the influence of a new medicinal drug FS-1.

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Purpose: The purpose of this study was to determine possible genotoxic effects of a new very promising antibacterial/antiviral drug FS-1.

Methods: The drug was tested in TA98, TA100, TA102, TA1535 and TA1537 strains of Salmonella (Ames test) with and without metabolic activation, and also in mouse lymphoma L5178Y cells by means of micronucleus and comet assays. In microbes the drug was tested at concentrations up to 500 μg/plate and in mouse lymphoma cells up to 2,000 μg/ml.

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