4 results match your criteria: "Sciences Center School of Medicine in Shreveport[Affiliation]"

Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells.

PLoS One

August 2015

Department of Molecular and Cellular Physiology, LSU Health Sciences Center School of Medicine in Shreveport, Shreveport, Louisiana, United States of America; The Feist-Weiller Cancer Center, LSU Health Sciences Center School of Medicine in Shreveport, Shreveport, Louisiana, United States of America.

The Wnt signaling pathway is often chronically activated in diverse human tumors, and the Frizzled (FZD) family of receptors for Wnt ligands, are central to propagating oncogenic signals in a β-catenin-dependent and independent manner. SIRT1 is a class III histone deacetylase (HDAC) that deacetylates histone and non-histone proteins to regulate gene transcription and protein function. We previously demonstrated that SIRT1 loss of function led to a significant decrease in the levels of Dishevelled (Dvl) proteins.

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Breast cancer remains one of the leading causes of death in women diagnosed with cancer. In breast cancer, aberrant expression of the CYP19A1 gene, which encodes the aromatase enzyme, contributes to increased intratumoral levels of estradiol. Regardless of whether this estrogen is produced by peripheral tissues or within specific subpopulations of cells within the breast tumor, it is clear that the aromatase enzymatic activity is critical for the growth of estrogen-dependent tumors.

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The role of sirtuin proteins in obesity.

Pathophysiology

August 2008

Molecular and Cellular Physiology, Feist-Weiller Cancer Center, Louisiana Health Sciences Center School of Medicine in Shreveport, 1501 Kings Highway, Shreveport, LA 71130, USA.

Although the progressive metabolic changes associated with obesity are complex, it is well-recognized that obesity is a risk factor for the development of insulin resistance and type 2 diabetes. Because both obesity and type 2 diabetes are associated with insulin resistance, there is significant interest in defining the mechanistic basis for insulin resistance. Recent studies involving SIRT1, the most intensely studied sirtuin family member, have shown that it regulates many metabolic adaptations linked with obesity.

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Vasculitis is defined as inflammation of blood vessels and can affect multiple organs. Several classification systems exist to categorize vasculitis such as vessel size, presence of anti-neutrophil cytoplasmic antibody, pathogenesis of the inflammation, and type of inflammatory cell infiltrate. Cutaneous vasculitis occurs as a manifestation of many diseases including rheumatologic diseases, hypersensitivity syndromes, infections, and malignancies.

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