Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk.

Immunological/inflammatory factors are implicated in the development of psychosis. Complement is a key driver of inflammation; however, it remains unknown which factor is better at predicting the onset of psychosis. This study aimed to compare the alteration and predictive performance of inflammation and complement in individuals at clinical high risk (CHR).

Soft Character of Star-Like Polymer Melts: From Linear-Like Chains to Impenetrable Nanoparticles.

The importance of microscopic details in the description of the behavior of polymeric nanostructured systems, such as hairy nanoparticles, has been lately discussed via experimental and theoretical approaches. Here we focus on star polymers, which represent well-defined soft nano-objects. By means of atomistic molecular dynamics simulations, we provide a quantitative study about the effect of chemistry on the penetrability of star polymers in a melt, which cannot be considered by generic coarse-grained models.

PhiPipe: A multi-modal MRI data processing pipeline with test-retest reliability and predicative validity assessments.

Magnetic resonance imaging (MRI) has been one of the primary instruments to measure the properties of the human brain non-invasively in vivo. MRI data generally needs to go through a series of processing steps (i.e.

Associations between parental mediation and adolescents' internet addiction: The role of parent-child relationship and adolescents' grades.

Introduction: Family factors, such as parental mediation on Internet use and parent-child relationships, have been shown to play a crucial role in preventing adolescents' internet addiction. Previous studies have shown a change in characteristics of online risk during adolescents' development. However, it is still of great interest whether such differences applied in the relationships among parent-child relationships, different types of parental mediation and adolescents' internet addiction level.

Starch Biocryogel for Removal of Methylene Blue by Batch Adsorption.

A green monolithic starch cryogel was prepared and applied for the removal of methylene blue (MB) using a batch system. The influence of various experimental parameters on MB adsorption was investigated. High removal efficiency (81.

The Anthocyanin Accumulation Related , Facilitates Seedling Salinity Stress Tolerance via ROS Scavenging.

Anthocyanins are a class of antioxidants that scavenge free radicals in cells and play an important role in promoting human health and preventing many diseases. Here, we characterized a maize gene () from the purple colored W22 introgression line, which encodes an anthocyanin 3-O-glucosyltransferase, a key enzyme in the anthocyanin synthesis pathway. Mutation of showed bronze-colored seeds and reduced anthocyanins in seeds aleurone layer, seedlings coleoptile, and stem of mature plants by comparison with purple colored W22 (WT).

Characterization and Optimization of Culture Conditions for sp. SC145 Isolated from Sand Cay (Son Ca) Island, Vietnam, and Antioxidative and Neuroprotective Activities of Its Polyunsaturated Fatty Acid Mixture.

is a heterotrophic marine microalga that has potential industrial applications. The main objectives of this study were to isolate an strain from Sand Cay (Son Ca) Island, Vietnam, optimize its culture conditions, determine its nutritional composition, extract polyunsaturated fatty acids (PUFAs) in the free (FFA) and the alkyl ester (FAAE) forms, and evaluate the antioxidation and neuroprotection properties of the PUFAs. sp.

Age-dependent alterations in the coordinated development of subcortical regions in adolescents with social anxiety disorder.

Subcortical brain regions play essential roles in the pathology of social anxiety disorder (SAD). While adolescence is the peak period of SAD, the relationships between altered development of the subcortical regions during this period and SAD are still unclear. This study investigated the age-dependent alterations in structural co-variance among subcortical regions and between subcortical and cortical regions, aiming to reflect aberrant coordination during development in the adolescent with SAD.

Response surface modeling of ceftriaxone removal from hospital wastewater.

In recent decades, an emerging concern of widespread antimicrobial resistance has been raised due to the existence of pharmaceutical samples such as antibiotics in an aqueous medium. Herein, antibiotic ceftriaxone (CTX) removal from hospital wastewater employing a hybrid process of electrocoagulation (EC) and adsorption (AD) was investigated. The response surface methodology (RSM) was employed to study the influences of main operating variables, including initial CTX concentration, pH, current density, reaction time, and chitosan dosage, on the removal efficiency of the treatment process.

First Report of Colletotrichum siamense Causing Anthracnose on Eriobotrya japonica in China.

Eriobotrya japonica (Thunb.) Lindl. is a subtropical evergreen tree with economic and medicinal value.

Specific and common functional connectivity deficits in drug-free generalized anxiety disorder and panic disorder: A data-driven analysis.

Evidence of comparing neural network differences between anxiety disorder subtypes is limited, while it is crucial to reveal the pathogenesis of anxiety disorders. The present study aimed to investigate specific and common resting-state functional connectivity (FC) networks in generalized anxiety disorder (GAD), panic disorder (PD), and healthy controls (HC). We employed the gRAICAR algorithm to decompose the resting-state fMRI into independent components and align the components across 61 subjects (22 GAD, 18 PD and 21 HC).

A methodology for determining the local mechanical properties of model atomistic glassy polymeric nanostructured materials.

We propose a methodology for calculating the distribution of the mechanical properties in model atomistic polymer-based nanostructured systems. The use of atomistic simulations is key in unravelling the fundamental mechanical behavior of composite materials. Most simulations involving the mechanical properties of polymer nanocomposites (PNCs) concern their global (average) properties, which are typically extracted by applying macroscopic strain on the boundaries of the simulation box and calculating the total (global) stress by invoking the Virial formalism over all atoms within the simulation box; thus, extracting the pertinent mechanical properties from the corresponding stress-strain relation.

Temperature and Humidity Regulate Sporulation of That Is Associated with Pathogenicity in Cucumber ( L.).

Cucumber target leaf spot, caused by , is an emerging disease with a high incidence that causes severe damage to cucumbers on a global scale. Therefore, efforts need to be undertaken to limit the spread and infection of this pathogen, preferably by using environmentally friendly methods. In this study, the effects of temperature and moisture on the sporulation of .

Dynamic analysis of the microbial communities and metabolome of healthy banana rhizosphere soil during one growth cycle.

Background: The banana-growing rhizosphere soil ecosystem is very complex and consists of an entangled network of interactions between banana plants, microbes and soil, so identifying key components in banana production is difficult. Most of the previous studies on these interactions ignore the role of the banana plant. At present, there is no research on the the micro-ecological environment of the banana planting growth cycle.

Simultaneous electrochemical degradation of pesticides from the aqueous environment using Ti/SnO-SbO/PbO/Bi electrode; process modeling and mechanism insight.

In this work, modified Bi-PbO electrode was fabricated and employed for simultaneous degradation of fenitrothion (FT), trifluralin (TF), and chlorothalonil (CT) from synthetic and pesticide wastewater through the anodic oxidation process. A novel high-performance liquid chromatography method was developed and optimized to identify the pesticides simultaneously. Quadratic models were developed to investigate the effects of main operating parameters and predict the degradation efficiencies of the treatment processes.

Synthesis of 1-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-2-morpholinoethane-1,2-dione analogues and their inhibitory activities with reduced cytotoxicity in lipopolysaccharide-induced BV2 cells.

A series of rimonabant analogues, where the N-aminopiperidine moiety was replaced by various amines and an additional carbonyl group, were synthesized and their inhibition of nitric oxide (NO) production was evaluated in lipopolysaccharide (LPS)-induced BV2 microglial cells. Among the synthesized compounds, the morpholine analogue 7y (IC = 4.71 ± 0.

Portable Colorimetric Hydrogel Test Kits and On-Mobile Digital Image Colorimetry for On-Site Determination of Nutrients in Water.

Portable colorimetric hydrogel test kits are newly developed for the on-site detection of nitrite, nitrate, and phosphate in water. Griess-doped hydrogel was prepared at the bottom of a 1.5 mL plastic tube for nitrite detection, a nitrate reduction film based on zinc powder was placed on the inner lid of a second 1.

Irreversible Electroporation Mediates Glioma Apoptosis via Upregulation of and : Transcriptome Evidence.

The heat-sink effect and thermal damage of conventional thermal ablative technologies can be minimized by irreversible electroporation (IRE), which results in clear ablative boundaries and conservation of blood vessels, facilitating maximal safe surgical resection for glioblastoma. Although much comparative data about the death forms in IRE have been published, the comprehensive genetic regulatory mechanism for apoptosis, among other forms of regulatory cell death (RCD), remains elusive. We investigated the electric field intensity threshold for apoptosis/necrosis (YO-PRO-1/PI co-staining) of the U251 human malignant glioma cell line with stepwise increased uniform field intensity.

Using Urinary Biomarkers to Estimate the Benzene Exposure Levels in Individuals Exposed to Benzene.

Urinary benzene metabolites trans, trans-muconic acid (-MA), and S-phenyl mercapturic acid (S-PMA) are often used as biomarkers of internal exposure to benzene. However, there are few reports on using urinary benzene metabolites to estimate airborne benzene concentrations in individuals exposed to benzene. In this study, -MA, and S-PMA were analyzed by UPLC-MS/MS, and a simple pharmacokinetic model was used to calculate the daily intake (DI) of benzene based on the levels of urinary -MA, and S-PMA in occupational individuals.

Guvermectin, a novel plant growth regulator, can promote the growth and high temperature tolerance of maize.

Guvermectin is a recently discovered microbial N9-glucoside cytokinin compound extracted from NEAU6. Although some research has reported that N9-glucoside cytokinin compounds do not have the activity of cytokinin, it has been noted that guvermectin can promote growth and antifungal activity in . Maize is an important food crop in the world and exploring the effect of guvermectin on this crop could help its cultivation in regions with adverse environmental conditions such as a high temperature.

Ecology of testate amoebae in waterbodies of the Central Highlands and South-Central Coast provinces of Vietnam with the description of new species Difflugia quangtrani sp. nov.

This study provides new data on ecology of testate amoebae in the waterbodies of the Central Highlands and South-Central Coast regions of Vietnam. A total of 108 species and subspecies including six new records for Vietnam were identified. One new species Difflugia quangtrani sp.

Embryonic Deletion of TXNIP in GABAergic Neurons Enhanced Oxidative Stress in PV+ Interneurons in Primary Somatosensory Cortex of Aging Mice: Relevance to Schizophrenia.

The brain is susceptible to perturbations of redox balance, affecting neurogenesis and increasing the risks of psychiatric disorders. Thioredoxin-interacting protein (TXNIP) is an endogenous inhibitor of the thioredoxin antioxidant system. Its deletion or inhibition suggests protection for a brain with ischemic stroke or Alzheimer's disease.

Gene and Single Nucleotide Polymorphisms, rs2072446 and rs11466162, Playing Roles in Psychiatric Disorders.

Psychiatric disorders are a class of complex disorders characterized by brain dysfunction with varying degrees of impairment in cognition, emotion, consciousness and behavior, which has become a serious public health issue. The gene encodes the p75 neurotrophin receptor, which regulates neuronal growth, survival and plasticity, and was reported to be associated with depression, schizophrenia and antidepressant efficacy in human patient and animal studies. In this study, we investigated its association with schizophrenia and major depression and its role in the behavioral phenotype of adult mice.