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Synthetic biology in probiotic lactic acid bacteria: At the frontier of living therapeutics.

Curr Opin Biotechnol

October 2018

Department of Chemical and Biological Engineering, Tufts University, 4 Colby St, Science and Technology Center 276, Medford, MA 02155, USA. Electronic address:

Article Synopsis
  • The trillions of microbes in the human body influence health and disease through various genetic, environmental, and lifestyle factors, shaping the human ecosystem.
  • Researchers are exploring ways to design microbes as therapeutic agents, which could enhance drug delivery and restore balance in disrupted microbial communities.
  • Lactic acid bacteria (LAB) have a safe history of use in food and health, making them suitable for engineered applications, and the review discusses genetic tools and future possibilities for LAB-based therapeutic systems.
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