Century-long West Antarctic snow accumulation changes induced by tropical teleconnections.

Ice core measurements reveal dipole-like snow accumulation trends over West Antarctica throughout the 20th century, with an increase of >2000 billion metric tons over the Antarctic Peninsula and Ellsworth Land but a decrease of ~500 billion metric tons over Marie Byrd Land. Although atmospheric teleconnections were frequently revealed, linking variability between tropics and higher latitudes on interannual and decadal timescales, centennial-scale teleconnection is absent from literature. Here, using statistical analysis and numerical experiments, we reveal that changes of tropical oceans throughout the 20th century drive the long-term Antarctic snowfall trend.

Inotodiol induces hepatocellular carcinoma apoptosis by activation of MAPK/ERK pathway.

Hepatocellular carcinoma(HCC) has a high mortality and morbidity rate and seriously jeopardizes human life. Chemicals and chemotherapeutic agents have been experiencing problems such as side effects and drug resistance in the treatment of HCC, which cannot meet the needs of clinical treatment. Therefore, finding novel low-toxicity and high-efficiency anti-hepatocellular carcinoma drugs and exploring their mechanisms of action have become the current problems to be solved in the treatment of HCC.

Nitrate induced hepatic fibrosis in tadpoles of Bufo gargarizans by mediating alterations in toll-like receptor signaling pathways.

The nitrate pollution has become an increasingly serious environmental problem worldwide, and the toxic effects of elevated nitrate levels in the environment on aquatic animals remain to be elucidated. The purpose of the present study was to investigate the mechanisms of liver injury to tadpoles after exposure to nitrate from embryonic to metamorphic climax and to assess the recovery process of liver function after cessation of exposure. In the group with continuous nitrate exposure, the livers and thyroid of tadpoles showed remarkably histological lesions, of this with structural disorganization of the hepatocytes, cellular atrophy, and fibrosis, as well as significant reduction in the follicular and colloidal area of the thyroid.

Inhibition of triglyceride metabolism-associated enhancers alters lipid deposition during adipocyte differentiation.

Triglyceride (TG) metabolism is a complex and highly coordinated biological process regulated by a series of genes, and its dysregulation can lead to the occurrence of disorders in lipid metabolism. However, the transcriptional regulatory mechanisms of crucial genes in TG metabolism mediated by enhancer-promoter interactions remain elusive. Here, we identified candidate enhancers regulating the Agpat2, Dgat1, Dgat2, Pnpla2, and Lipe genes in 3T3-L1 adipocytes by integrating epigenomic data (H3K27ac, H3K4me1, and DHS-seq) with chromatin three-dimensional interaction data.

Metallic Nanostructures: An Updated Review on Synthesis, Stability, Safety, and Applications with Tremendous Multifunctional Opportunities.

Metallic nanostructures play a vital role in technological advancement, providing exceptional performance and improved adaptability in comparison to their bulk equivalents. Conventional synthesis techniques frequently depend on dangerous reducing agents to transform metal ions into Nanoparticles (NPs), which presents considerable environmental and health issues. In contrast, the approach of green synthesis, which emphasizes the use of non-toxic reagents, has garnered significant interest as a sustainable method for the fabrication of Metallic Nanoparticles (MNPs).

Nursing professionalism and associated factors in Ethiopia: a systematic review and meta-analysis.

Background: A higher level of nursing professionalism improves autonomy among nurses, the quality of nursing care, and patient outcomes. However, inconsistent findings on the prevalence of nursing professionalism and associated factors have been reported among studies conducted in Ethiopia, and a meta-analysis of pooled results have not been performed. Therefore, the aim of this systematic review and meta-analysis was to determine the pooled prevalence of higher levels of nursing professionalism and factors associated with it.

Shearinines U-Y, indole diterpenoids from an entomogenous fungus, sp.

Five new indole diterpenoids, shearinines U-Y (2-6), and the known compound 22,23-dehydro-shearinine A (1) were isolated from cultures of the entomogenous fungus sp. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 2-6 were assigned by electronic circular dichroism calculations, respectively.

Fabrication of water-dispersible dye/polymer matrix-stabilized β-FeOOH (Rh-B/F127@β-FeOOH) nanoparticles: synthesis, characterization and therapeutic applications.

In this study, dye/polymer matrix-stabilized β-FeOOH nanomaterials were fabricated for therapeutic applications. Rh-B/F127@β-FeOOH nanomaterials were synthesized using two different methods: co-precipitation (CoP) and hydrothermal (HT) methods. The as-synthesized nanoparticles were characterized using various spectroscopic techniques, including FT-IR, UV-Vis, PL, XRD, HR-TEM, and XPS analysis.

The interplay between personal traits and coping strategies on shift-work tolerance: a cross-sectional study.

The ability to adapt to night shift work varies greatly among individuals, but little is known about how personal traits and coping strategies interact to affect shift-work tolerance. This study aimed to identify how certain personal traits (e.g.

Identification of Strains from Animal Cases in Ethiopia and Genetic Characterization by Whole-Genome Sequencing.

Anthrax is a zoonotic disease characterized by rapid onset with usual fatal outcomes in livestock and wildlife. In Ethiopia, anthrax is a persistent disease; however, there are limited data on the isolation and molecular characterization of strains. This study aimed to characterize isolated from animal anthrax outbreaks between 2019 and 2024, from different localities in Ethiopia.

Investigation and Identification of Fungal Diseases of in China.

The industry plays an important role in the economic development of Yuanjiang county of Yuxi city in Yunnan province, China. In order to reduce the harm of diseases and ensure the quality of products, the occurrence of was investigated. The pathogenic fungi of wild and cultivated species of were isolated by a tissue separation method, and DNA sequencing was carried out by using the sequence analysis of the ribosomal rDNA-ITS region, and the pathogenic fungi were classified and identified by finally combining morphological observations.

Synthesis, molecular dynamics simulation and antimicrobial activity of novel s-triazine clubbed with three different hybrid pharmacophores.

To address microbial infections and combat drug resistance, we designed, synthesized, and evaluated three novel s-triazine clubbed pharmacophores: 1-acetylpyrazoline (5a-e), 2-aminopyrimidine (6a-e), and 1,5-benzodiazepine (7a-e). These were derived from chalcone (4a-e), showing improved pharmacological profiles. The compounds underwent characterization by FTIR, NMR, and Mass Spectroscopy, and their antimicrobial activities, along with structure-activity relationships (SAR), were assessed using in silico and in vitro methods.

Single-cell RNA sequencing elucidates cellular plasticity in esophageal small cell carcinoma following chemotherapy treatment.

Small cell carcinoma of the esophagus (SCCE) is a rare and aggressively progressing malignancy that presents considerable clinical challenges.Although chemotherapy can effectively manage symptoms during the earlystages of SCCE, its long-term effectiveness is notably limited, with theunderlying mechanisms remaining largely undefined. In this study, weemployed single-cell RNA sequencing (scRNA-seq) to analyze SCCE samplesfrom a single patient both before and after chemotherapy treatment.

Optimizing CsCuBiBr double halide perovskite for solar applications: the role of electron transport layers in SCAPS-1D simulations.

Perovskite solar cells are commonly employed in photovoltaic systems because of their special characteristics. Perovskite solar cells remain efficient, but lead-based absorbers are dangerous, restricting their manufacture. Therefore, studies in the field of perovskite materials are now focusing on investigating lead-free perovskites.

The mediating effect of self-efficacy and physical activity with the moderating effect of social support on the relationship between negative body image and depression among Chinese college students: a cross-sectional study.

Background: Fitness to maintain an ideal body shape is becoming increasingly popular among college students. However, it also leads to many mental health issues. This study explores the pathways through which negative body image affects depression in college students.

Metaproteomics reveals metabolic activities potentially involved in bloom formation and succession during a mixed dinoflagellate bloom of Prorocentrum obtusidens and Karenia mikimotoi.

Understanding metabolic activities involved in bloom formation during a single-species algal bloom has improved greatly. However, little is known about metabolic activities during a multi-species algal bloom. Here, we investigated protein expression profiles at different bloom stages of a mixed dinoflagellate bloom caused by Karenia mikimotoi and Prorocentrum obtusidens (syn.

Integrating immunity, antioxidative status, and gene regulation against nickel and high-temperature stress in fish: selenium nanoparticles for mitigation.

Fish face health hazards due to high-temperature (T) stress and the toxicity associated with nickel (Ni), both of which can occur in aquatic ecosystems. The accumulation of nickel in fish may pose risks to human health when contaminated fish are consumed. Consequently, the goal of this study was to clarify how selenium nanoparticles (Se-NPs) help Pangasianodon hypophthalmus by reducing the effects of nickel and high-temperature stress.

Predictors of client satisfaction with family planning services in Ethiopia: a systematic review and meta-analysis.

Background: The use of modern contraceptives by married Ethiopian women has increased over the past 15 years. Despite a few studies reporting different predictors of satisfaction with family planning services, there is a lack of nationwide data showing the determinants of client satisfaction with family planning services. Thus, this meta-analysis aimed to determine the predictors of client satisfaction with family planning services in Ethiopia.

Extended-spectrum beta-lactamase and carbapenemase-producing Gram-negative bacteria in urinary tract infections in Ethiopia: a systematic review and meta-analysis.

Background: Urinary tract infection (UTI) is one of the most common infections worldwide, particularly in developing countries. It also is among the most prevalent nosocomial infections, largely due to the widespread use of urinary catheters in hospitalized patients. These catheters often act as reservoirs for multidrug-resistant bacteria, including extended-spectrum beta-lactamase- and carbapenemase-producing pathogens, which significantly limit treatment options and delay appropriate care.

Influence of chitosan-capped quercetin nanoparticles on chitosan/poly(vinyl) alcohol multifunctional films: A sustainable approach for bread preservation.

Food packaging industries are growing to meet consumer demand and prevent pollution by adopting significant biopolymer advancements. Therefore, this study aimed to develop functionally active chitosan (CS)/polyvinyl alcohol (PVA)-based biopolymer films and evaluate the effect of Justicia Adhatoda extract (JAE), pure quercetin (Q), and CS-capped quercetin nanoparticles ((Q) NPs) on sustainable bread packaging. CS was successfully loaded onto (Q) by the one-pot method, which was confirmed by light absorption spectroscopy (UV), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD).

Phytantriol phase behaviour in deep eutectic solvent-water mixtures.

Deep eutectic solvents are highly tailorable non-aqueous solvents with potential applications ranging from energy catalysis to cryopreservation. Self-assembled lipid structures are already used in a variety of industries including cosmetics, drug delivery and as microreactors. However, most research into lipid self-assembly has been limited to aqueous solvents.

A comprehensive review of probiotics and human health-current prospective and applications.

The beneficial properties of probiotics have always been a point of interest. Probiotics play a major role in maintaining the health of Gastrointestinal Tract (GIT), a healthy digestive system is responsible for modulating all other functions of the body. The effectiveness of probiotics can be enhanced by formulating them with prebiotics the formulation thus formed is referred to as synbiotics.

Physicochemical properties, structural analysis, and activity of Shancigu polysaccharides.

Objective: To investigate the physicochemical properties, structural characteristics and in vitro activities of Shancigu polysaccharides to identify the authenticity of Shancigu, safeguard its medicinal value, and ensure the safety of its market distribution.

Methods: Eleven polysaccharides from different sources of Shancigu were obtained using water extraction and alcohol precipitation. Physicochemical properties were determined using colorimetry.

Fungal Planet description sheets: 1697-1780.

Novel species of fungi described in this study include those from various countries as follows: , from accumulated snow sediment sample. , on leaf spots of . , on submerged decaying wood in sea water, on , as endophyte from healthy leaves of .