1-Pyrene Carboxylic Acid: An Internalization Enhancer for Short Oligoarginines.

Getting through the cell membrane is challenging, and transporting a therapeutic agent while entering the cell is even more complicated. Cell-penetrating peptides (CPPs) are valuable tools for solving this problem, although they have drawbacks. In this work, the synthesis and investigation of efficient CPPs are described.

Base-Labile Safety-Catch Linker: Synthesis and Applications in Solid-Phase Peptide Synthesis.

The safety-catch concept involves a protecting group that remains stable under a range of chemical conditions and subsequently becomes labile under one of those conditions upon a chemical modification of the protecting group. The safety-catch approach introduces flexibility into the scheme, enabling the use of the same reagent in two distinct steps of the chemical process. For example, it facilitates α-amino deprotection and final cleavage in a solid-phase peptide synthesis scheme.

Point-of-Care Diagnostic Test for Rapid Detection of Infectious Laryngotracheitis Virus by Loop-Mediated Isothermal Amplification and Nanoprobes.

Infectious laryngotracheitis virus (ILTV), a DNA virus classified as , causes a highly contagious respiratory disease in chickens, leading to significant economic losses and health risks for the poultry industry. The rapid detection of ILTV is essential to control its spread and prevent outbreaks. Traditional diagnostic methods like PCR are costly, require specialized personnel, and delay response efforts.

Hydrophilic Sulfonate Covalent Organic Frameworks for Serum Glycopeptide Profiling.

Aberrant protein glycosylation is closely associated with a number of biological processes and diseases. However, characterizing the types of post-translational modifications (PTMs) from the complex biological samples is challenging for comprehensive glycoproteomic analysis. The development of high-performance enrichment materials and strategies during the sample pretreatment process is a prerequisite to glycoproteome research.

The Electronic Structure and Bonding in Some Small Molecules.

The electronic structures of the first- and second-row homonuclear diatomics, XeF, and the weakly bound dimers of nitric oxide and nitrogen dioxide molecules in their ground states are discussed in terms of molecular orbital (MO) theory and, where possible, valence bond theories. The current work is extended and supported by restricted and unrestricted Hartree-Fock (RHF and UHF) self-consistent field (SCF), complete active space SCF (CASSCF), multi-reference configuration interaction (MRCI), coupled cluster CCSD(T), and unrestricted Kohn-Sham (UKS) density functional calculations using a polarized triple-zeta basis. The dicarbon (C) molecule is especially poorly described by RHF theory, and it is argued that the current MO theories taught in most undergraduate courses should be extended in recognition of the fact that the molecule requires at least a two-configuration treatment.

Preparation and Properties of F-Doped PrBaSrCoO Perovskite Cathode Materials.

F-doped PrBaSrCoOF (PBSCF, = 0, 0.025, 0.05, 0.

Schiff Base Compounds Derived from 5-Methyl Salicylaldehyde as Turn-On Fluorescent Probes for Al Detection: Experimental and DFT Calculations.

Using 5-methyl salicylaldehyde () as a reactant to react with different amines, 2-aminobenzimidazole (), 2-aminobenzothiazole (), and 2-aminopyridine (), respectively, three types of Schiff base fluorescent probes - were designed and synthesized for selective detection of Al in aqueous media. The structure of the compounds was acquired by H NMR, C NMR, and X-ray single-crystal diffraction. Furthermore, their photochromic and fluorescent behaviors have been investigated systematically by fluorescence spectra.

Facile Synthesis of Sandwich-Type Porous Structured Ni(OH)/NCNWs/rGO Composite for High Performance Supercapacitor.

Nickel hydroxide has ultra-high energy storage capacity in supercapacitors, but poor electrical conductivity limits their further application. The use of graphene to improve its conductivity is an effective measure, but how to suppress the stacking of graphene and improve the overall performance of composite materials has become a new challenge. In this work, a well-designed substrate of N-doped carbon nanowires with reduced graphene oxide (NCNWs/rGO) was fabricated by growing polypyrrole (PPy) nanowires between GO nanosheets layers and then calcining them at high temperatures.

Faberidilactone A, a Sesquiterpene Dimer, Inhibits Hepatocellular Carcinoma Progression Through Apoptosis, Ferroptosis, and Anti-Metastatic Mechanisms.

Cancer remains a significant global public health challenge, with hepatocellular carcinoma (HCC) ranking among the top five malignancies in terms of mortality. Faberidilactone A, a sesquiterpenoid dimer isolated from , exhibits potent cytotoxicity against various human tumor cell lines and demonstrates remarkable antitumor potential. In vitro studies using HepG2 cells revealed that faberidilactone A induces apoptosis and ferroptosis, causes cell cycle arrest, enhances the production of intracellular reactive oxygen species (ROS), and disrupts mitochondrial function.

Evaluation and Characterization of High-Uniformity SiN Thin Film with Controllable Refractive Index by Home-Made Cat-CVD Based on Orthogonal Experiments.

Silicon nitride (SiN) thin film is a promising coating with great physiochemical and optical properties. However, the preparation of films with good comprehensive properties still faces challenges. This study focused on developing a method for the preparation of uniform SiN thin film with a controllable refractive index using home-made catalytic chemical vapor deposition (Cat-CVD) equipment.

MOF-Derived N-Doped Carbon Nanotube-Confined Ni Nanoparticles for the Simultaneous Electrochemical Detection of Cu²⁺ and Hg²⁺ with High Sensitivity and Stability.

Heavy metal pollution has posed a serious threat to the ecological environment and human health. Thus, the development of accurate and effective methods for their detection is crucial. In this study, a novel electrochemical sensor was fabricated to detect Cu and Hg, based on N-doped carbon nanotube-wrapped Ni nanoparticle (Ni@N-CNT) sensing material, which was derived from the pyrolysis of Ni doped ZIF-8.

Impregnation of SeS into a Nitrogen- and Sulfur-Co-Doped Functional Metal Carbides and Nitrides for High-Performance Li-S Batteries.

In this study, nitrogen- and sulfur-co-doped MXene (NS-MXene) was developed as a high-performance cathode material for lithium-sulfur (Li-S) batteries. Heterocyclic SeS molecules were successfully confined within the NS-MXene structure using a simple melt impregnation method. The resulting NS-MXene exhibited a unique wrinkled morphology with a stable structure which facilitated rapid ion transport and provided a physical barrier to mitigate the shuttle effect of polysulfide.

Liquid-Assisted Grinding Enables Efficient Ni-Catalyzed, Mn-Mediated Denitrogenative Cross-Electrophile Coupling of Benzotriazinones with Benzyl Chlorides.

An efficient and air-tolerant Ni-catalyzed denitrogenative cross-electrophile coupling of benzotriazinones with benzyl chlorides has been developed via liquid-assisted grinding by using Mn powders as reductant and DMF as assisting liquid in the presence of anhydrous calcium chloride. Scope and limitations of the protocol to access diarylmethanes have been demonstrated with more than 20 examples, showing acceptable tolerance to functional group and steric hindrance. Although electron-withdrawing substituents on benzotriazinone or benzyl counterparts decrease the yields significantly, a series of N-alkyl-2-benzylbenzamides, diarylmethanes bearing an ortho-carbamoyl aryl group, could be obtained in modest to good yields.

A Dual-Function Fe-Doped CoO Nanosheet Array for Efficient OER and HER in an Alkaline Medium.

The electrocatalysts of heteroatom-doped non-precious metal oxide materials are of great significance for efficient and low-cost electrochemical water-splitting systems. Herein, an innovative Fe-doped CoO nanoflake (Fe-CoO/NF) on nickel foam has been developed, which exhibits excellent electrocatalytic activity for both hydrogen evolution reactions (HERs) and oxygen evolution reactions (OERs). Benefiting from the synergy of the charge redistribution and d-band center shift caused by doping engineering, the as-obtained Fe-CoO/NF shows both excellent HER ( = 196 mV) and OER ( = 290 mV) activities with low Tafel slopes (109 mV dec for HER and 49 mV dec for OER, respectively) and excellent stability.

Upcycling of Waste Durian Peel into Valued Fe/N Co-Doped Porous Materials as Peroxymonosulfate Activator for Terramycin Oxidation.

Nitrogen-doped graphene-coated Fe nanoparticles (EC@NFe-700) were synthesized through the pyrolysis of a durian peel-supported urea ferric salt mixture. These materials were subsequently utilized to activate peroxymonosulfate (PMS) for oxidation of terramycin (TEC). The incorporation of an optimal amount of urea and ferric nitrate during the synthesis of materials significantly improves the catalytic activity of the resulting catalysts after pyrolysis.

The Incorporation of Nanoconfined Poly(ionic liquid)s with Two-Dimensional Covalent Organic Frameworks to Enhance Proton Conduction.

Covalent organic frameworks (COFs) hold promising potential as high-temperature proton conductors due to their highly ordered nanostructures and high specific surface areas. However, due to their limited functional groups and poor membrane-engineering properties, finding practical applications for COF-based proton-conducting materials still remains challenging. Herein, we proposed a universal strategy to fabricate proton-conducting composite membranes by the incorporation of sulfonic acid-bearing COFs and zwitterionic poly(ionic liquid)s (PILs) via in situ polymerization.

A Review of Recent Developments in Analytical Methods for Determination of Phosphorus from Environmental Samples.

Phosphorus is essential to environmental systems because it affects both agricultural productivity and ecological balance. Since it contributes to eutrophication and pollution problems, its existence in a variety of environmental matrices, including soil, water, and air, necessitates precise and effective determination methods for monitoring and managing its levels. This review paper provides an extensive overview of the latest advancements in analytical techniques for measuring phosphorus in environmental samples.

Chemical Analysis and Antioxidant Activities of Resin Fractions from L. in Neuroblastoma SH-SY5Y Cells.

Chios mastiha is the natural aromatic resin of L. , which is exclusively cultivated in the southern part of the Greek island of Chios. Chios mastiha (/Chios mastiha) is well-known for its distinctive taste and aroma and has been known since ancient times due to its healing properties in gastrointestinal and inflammatory disorders and because of its anti-bacterial and anti-fungal activities.

The Facile Synthesis of Exogenous Lewis-Base-Free Amidoalanes: A Structural Comparison.

A simple one-pot reaction of LiAlH, AlCl, and a secondary amine HNR [R = Et, Pr, Bu, cyclo-CH, (CH), and (CH)] in hydrocarbon solvents results in the formation of exogenous Lewis-base-free amidoalanes [HAl(NR)] (n = 2 or 3) as crystalline solids (35-85% yield). In the solid state (seven X-ray structures), all the amidoalanes exist as dimers, with the exception of the pyrrolidine-derived alane which exists as a trimer. As solids, these amidoalanes exhibit significant kinetic stability towards oxygen/moisture allowing the brief (ca.

Applications of Metal-Organic Frameworks and Their Derivatives in Fuel Cells.

Metal-organic frameworks (MOFs) and their derivatives represent a novel class of porous crystalline materials characterized by exceptional porosity, high specific surface areas, and uniquely tunable physicochemical properties. These attributes render them highly promising for applications in the field of fuel cells. This review provides a comprehensive overview of the classification of MOFs and their current applications as catalysts, catalyst supports, and membranes in fuel cells.

Functionalization of Phenolic Aldehydes for the Preparation of Sustainable Polyesters and Polyurethanes.

Biobased organic diols derived from the phenolic aldehyde by-products in the depolymerization of lignin (4-hydroxybenzaldehyde, vanillin, and syringaldehyde) for the synthesis of polyesters and polyurethanes is described. Methods to prepare lignin-based diols involved a two-step synthetic route using either a hydroxy alkylation and aldehyde reduction or an aldehyde reduction and Williamson-Ether substitution. The preparation of five polyesters (PEs) and ten polyurethanes (PUs) from lignin-based diols was also performed and their physical and thermal properties were analyzed.

Enhanced Piezoelectric Performance of Highly-Aligned ZnO Nanorods Embedded in P(VDF-TrFE) Nanofiber Membranes.

Flexible and wearable electronics often rely on piezoelectric materials, and Poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) membranes are popular for this application. However, their electromechanical performance is limited due to a relatively low piezoelectric coefficient. To address this, this study investigates the incorporation of zinc oxide (ZnO) nanorods (NRs) into a P(VDF-TrFE) nanofiber membrane matrix.

Research Advances in Natural Polymers for Environmental Remediation.

The search for sustainable and efficient remediation techniques is required to control increasing environmental pollution caused by synthetic dyes, heavy metal ions, and other harmful pollutants. From this point of view, natural polymers like chitosan, cellulose, lignin, and pectin have been found highly promising due to their biodegradability, availability, and possibility of chemical functionalization. Natural polymers possess inherent adsorption properties that can be further enhanced by cross-linking and surface activation.

Improvement Catalytic Efficiency of the Fenton-Like Reaction via the Interaction among Fe Species Encapsulated in N-Doped Carbon Materials.

The Fenton-like reaction has been widely used for environmental modification. However, improvement of the catalytic efficiency is still a challenge. In this study, a series of core-shell-shaped catalysts (FeNC-, presents the calcination temperature) for the Fenton-like reaction was fabricated through the pyrolysis of the Fe-based metal-organic frameworks (Fe-MOF).

Direct Observation of Cyclo-Pentazolate Anion Decomposition in a Tailored Molecular Trap.

The cyclo-pentazolate anion (cyclo-N5-) has garnered significant attention as an all-nitrogen, five-membered-ring ion with a high-energy state and unique aromaticity. Typically, the free cyclo-N5- anion is a highly unstable species, and its stabilization relies on strong interactions, such as a hydrogen bonding network or metal coordination. However, these interactions often compromise the independence of the anion, thus diminishing its aromaticity.