Biomimetic Synthesis of the Marine-Derived Thioalkaloids Dassonmycins A and B.

A biomimetic synthesis of the marine thioalkaloids dassonmycins A and B is reported. The synthesis features a chemoselective reduction of a diketopiperazine to form a 2-piperazinone, which undergoes heteroannulation with naphthoquinone to yield dassonmycin A. Dassonmycin A undergoes slow cyclization to form dassonmycin B at physiological pH, supporting a biosynthesis hypothesis that this reaction could occur in the cytosol of the bacterial host species.

Bio-based polylactic acid labware as a sustainable alternative for microbial cultivation in life science laboratories.

Single-use plastics (SUPs) in life science laboratories account for approximately 5.5 million tonnes of waste per year globally. Of SUPs used in life science laboratories, Petri dishes, centrifuge tubes, and inoculation loops are some of the most common.

Adjuvant strategies to tackle -mediated polymyxin resistance.

The emergence of the () gene is a demonstrable threat contributing to the worldwide antibiotic resistance crisis. The gene is encoded on plasmids and can easily spread between different bacterial strains. encodes a phosphoethanolamine (pEtN) transferase, which catalyses the transfer of the pEtN moiety from phosphatidylethanolamine to lipid A, the head group of lipopolysaccharides (LPS).

Production of Branched Alkanes by Upcycling of Waste Polyethylene over Controlled Acid Sites of SO/ZrO-AlO Catalyst.

Branched alkanes, which enhance the octane number of gasoline, can be produced from waste polyethylene. However, achieving highly selective production of branched alkanes presents a significant challenge in the upcycling of waste polyethylene. Here, we report a one-pot process to convert polyethylene into gasoline-range hydrocarbons (C-C) with yield of 73.

Aqueous Dispersion Polymerization for the Development of Lamivudine-Polyacrylonitrile Nanoparticles through Quality by Design Approach.

The development of polymeric nanoparticles (NPs) from preformed polymers usually requires the use of organic solvents and is more expensive. Hence, in this work, the development of polymeric nanoparticles by in situ aqueous dispersion polymerization from the monomers was set as an objective. Acrylonitrile monomer based polymeric NPs comprising Lamivudine (LMV) as a model drug were prepared using the aqueous dispersion polymerization technique.

NIR emissive probe for fluorescence turn-on based dead cell sorting and viscosity mapping in .

Dead cell sorting is pivotal and plays a very significant role in homeostasis. Apoptosis and ferroptosis are the two major regulatory cell death processes. Apoptosis is a programmed cell death process, while ferroptosis is a regulatory cell death process.

Molecular self-assembly of stable and small branched DNA nanostructures: Higher than a helical turn is enough for hybridization.

The Watson-Crick base pairing property of DNA is widely used for fabricating DNA nanostructures with well-defined geometry. Moreover, DNA nanostructures can be easily modified in terms of shape, size and function at the nanoscale level. Therefore, investigation on smaller and stable branched DNA (bDNA) is of critical significance for biomedical applications.

Colorimetric and fluorometric sensing of polar E120 in juice and environmental water samples using mannitol-functionalized magnetic nanoparticles and nitrogen-doped carbon dots.

In this study, mannitol-functionalized magnetic nanoparticles (MMNPs) as a unique nanosorbent and N-doped fluorescent carbon dots (N-CDs) as a cost-effective nanosensor were created and utilized, for the first time, for dispersive micro-solid-phase extraction (Dµ-SPE) to determine carmine (E120) dye in water samples and juices. The modification of the magnetic nanoparticles with mannitol was designed to enhance the responsive potential for adsorption of the polar E120 dye from complex sample matrices through electrostatic interaction. The as-fabricated N-CDs fluorescent probe exhibited a high fluorescence quantum yield (Φs) of 43.

Magnesium Bicarbonate-Walnut Shell Dual-Template Synthesis of Multifunctional Layered Porous Carbon for Enhanced Adsorption of Aqueous Chlorinated Organic Compounds.

Chloride ions readily react with organic matter and other ions, resulting in the formation of disinfection by-products (DBPs) that exhibit heightened levels of toxicity, carcinogenicity, and mutagenicity. This study creatively employed waste walnut shells as self-templates and low-cost magnesium bicarbonate as a rigid template to successfully synthesize multifunctional porous carbon derived from walnut shells. Employing a series of characterization techniques, it was ascertained that the porous carbon material (WSC/Mg) synthesized via the dual-template method exhibited a distinct layered microscopic surface structure, with a predominance of C and O elements on the surface.

The Efficacy of a Ferric Sillen Core-Linked Polymer in Suppressing the Pathogenicity of .

spp. are considered the leading bacterial cause of human gastroenteritis in the world. The development of effective intervention strategies aimed at limiting infections has encountered various challenges, including a lack of an appropriate animal model.

Porphyrin-Polymer as a Photosensitizer Prodrug for Antimicrobial Photodynamic Therapy and Biomolecule Binding Ability.

This study presents the development and characterization of a novel porphyrin-Jeffamine polymer conjugate designed to function as a photosensitizer prodrug for antimicrobial photodynamic therapy (aPDT). The conjugate features a photosensitive porphyrin unit covalently attached to a biocompatible polymer backbone, with enhanced solubility, stability, and bioavailability compared to those of the free porphyrin derivatives. The photophysical properties were studied using transient absorption spectroscopy spanning the fs-μs time scales in addition to emission studies.

Probing Aromaticity with Supersonic Jet Spectroscopy: A Case Study on Furan, Thiophene, and Selenophene.

Aromaticity is a century-old concept that is even introduced in high school textbooks. However, the determination of the order of aromaticity of molecules as simple as furan, thiophene, and selenophene is still challenging. This work describes how different theoretical and experimental methods posit different aromaticity orders.

Smart molecular designs and applications of activatable organic photosensitizers.

Photodynamic therapy (PDT) - which combines light, oxygen and photosensitizers (PS) to generate reactive oxygen species - has emerged as an effective approach for targeted ablation of pathogenic cells with reduced risk of inducing resistance. Some organic PS are now being applied for PDT in the clinic or undergoing evaluation in clinical trials. A limitation of the first-generation organic PS was their potential off-target toxicity.

Selective hydrogenolysis of the Csp-O bond in the furan ring using hydride-proton pairs derived from hydrogen spillover.

Selective hydrogenolysis of biomass-derived furanic compounds is a promising approach for synthesizing aliphatic polyols by opening the furan ring. However, there remains a significant need for highly efficient catalysts that selectively target the Csp-O bond in the furan ring, as well as for a deeper understanding of the fundamental atomistic mechanisms behind these reactions. In this study, we present the use of Pt-Fe bimetallic catalysts supported on layered double hydroxides [PtFe /LDH] for the hydrogenolysis of furanic compounds into aliphatic alcohols, achieving over 90% selectivity toward diols and triols.

Exploring a tristhione scorpionate ligand as a suitable chelator for the theranostic pair antimony-119 and antimony-117.

Background: The highly potent Auger electron emitter antimony-119 (Sb) and the SPECT-isotope antimony-117 (Sb) comprise a true theranostic pair particularly suitable for cancer theranostics. Harnessing this potential requires development of a chelator that can rapidly form a stable complex with radioactive antimony ions at the low concentrations typical of radiopharmaceutical preparations. Stable Sb(III) complexes of hydrotris(methimazolyl)borate (TMe) are known, prompting our investigation of this chelator.

Substitutional control of non-statistical dynamics in the thermal deazetization of tetracyclic azo compounds.

Dynamical control of reactivity for the deazetization of ,-9,10-diazatetracyclo[3.3.2.

Photocatalytic Decarboxylative Cross-Coupling of α,β-Unsaturated Acids with Amines for α-Ketoamides via C-N Bond Formation.

An unprecedented oxidative decarboxylative chemical domain of α,β-unsaturated acids and amines for C-N cross-coupled α-ketoamidation is disclosed. Molecular oxygen as a source oxygen in amide and water oxygen in the ketone segment furnished a green and sustainable synthesis of α-ketoamide from feedstock acids and amines. Mechanistically, photocatalyst travels with reductive quenching cycle, whereas pallado-cycle proceeded through oxidative C-N bond formation.

Dual Emission and Low-Temperature Afterglow in Xanthone-Dibenzoazepine for High EQE Host-Guest OLEDs with Low-Efficiency Roll-Off.

Research has been driven to demonstrate organic light-emitting diodes (OLEDs) with high efficiency, and in the quest for new materials, thermally activated delayed fluorescence (TADF) emitters have been employed. Preparation of donor-acceptor (D-A) π-conjugates is a useful guideline for developing TADF emitters. TADF emitters have shown excellent progress and high maximum external quantum efficiency (EQE) for OLEDs in the recent past; however, they suffer with substantial roll-off resulting in a decrease in their efficiency.

Computational insights into selective glucose to 5-hydroxymethylfurfural (HMF) conversion by reducing humins formation in aqueous media under Brønsted acid-catalyzed conditions.

5-Hydroxymethylfurfural (HMF) is known for its potential in biofuel production and as a platform chemical for many commercially important molecules. The cost-effective large-scale production of HMF from glucose is hampered by its poor yield in aqueous media due to the formation of polymeric side products known as humins. Thus, reducing humins formation is a strategy for the efficient conversion of glucose to HMF.

CsPbBr-PbSe Perovskite-Chalcogenide Epitaxial Nanocrystal Heterostructures and Their Charge Carrier Dynamics.

Lead halide perovskite and chalcogenide heterostructures which share the ionic and covalent interface bonding may be the possible materials in bringing phase stability to these emerging perovskite nanocrystals. However, in spite of significant successes in the development of halide perovskite nanocrystals, their epitaxial heterostructures with appropriate chalcogenide nanomaterials have largely remained unexplored. Keeping the importance of these materials in mind, herein, epitaxial nanocrystal heterostructures of CsPbBr-PbSe are reported.

Osteogenic citric acid linked chitosan coating of 3D-printed PLA scaffolds for preventing implant-associated infections.

>25 % of the patients who receive orthopedic implants have been reported with implant-associated osteomyelitis, which can result in inflammation, osteolysis, and aseptic loosening of implants. Current treatment methods doesn't ensure defect healing and prevention from reinfection. Thermoplastic-based 3D-printed scaffolds offer a bioresorbable, biocompatible, and mechanical strong implant system.

Potential of water-soluble chitosan Schiff bases extracted from Metapenaeus dobsoni shells as effective corrosion inhibitors.

Corrosion causes significant economic losses and structural failures in industries, highlighting the need for eco-friendly inhibitors. Chitosan (CS), a biodegradable and non-toxic biopolymer, shows potential, though its limited water solubility restricts its applications. To overcome this challenge, this study presents the synthesis of two water-soluble chitosan Schiff bases (CSBs) derived from the shells of Metapenaeus dobsoni (M.

Photoexcitation-Assisted Molecular Doping for High-Performance Polymeric Thermoelectric Materials.

Molecular doping plays a crucial role in modulating the performance of polymeric semiconductor (PSC) materials and devices. Despite the development of numerous molecular dopants and doping methods over the past few decades, achieving highly efficient doping of PSCs remains challenging, primarily because of the inadequate matching of frontier energy levels between the host polymers and the dopants, which is critical for facilitating charge transfer. In this work, we introduce a novel doping method termed photoexcitation-assisted molecular doping (PE-MD), capable of transcending limitations imposed by energy level disparities through the mediation of efficient photoinduced electron transfer between polymers and dopants.