Resinacein S ameliorates the obesity in mice via activating the brown adipose tissue.

Brown adipose tissue (BAT) is an ideal target organ for obesity treatment. Resinacein S is extracted from Ganoderma lucidum and can elevate Uncoupling protein 1 (UCP1) in cells, but its related effects at the animal level are not clear. The mice were fed with high-fat diet to construct obesity models and treated with Resinacein S.

The integration of optimizing train timetables with EMU route plans.

Generally, to address the resource management issues in high-speed railway operations, particularly in the context of large-scale networked high-speed train transportation organizations, a phased optimization approach is introduced. This approach divides the problem into two stages: the high-speed train timetabling and the planning of Electric Multiple Unit (EMU) route. The lack of direct integration between these stages has hindered the flexible and efficient utilization of line capacity and EMU resources based on large-scale network, limiting the potential for mutual compensation and coordination among different types of resources across different regions.

Preparation and mechanical performance of fluorite tailings geopolymer precursor under alkaline heat activation.

As one of the bulk solid wastes in the Yellow River basin in China, fluorite tailings urgently need to be utilized as resources. In this paper, NaOH and NaCO were used for alkali thermal activation of ground fluorite tailings under different temperature conditions, and the reactivity was analyzed by XRD, SEM and compressive strength after hydration, so as to evaluate the feasibility of fluorite tailings as geopolymer precursor. The results show that the fluorite tailings can exhibit certain reactivity under alkaline heat excitation, and significant amorphous glass phase can be detected.

METTL3 inhibition promotes radiosensitivity in hepatocellular carcinoma through regulation of SLC7A11 expression.

Radiotherapy is one of the main treatment modalities for advanced hepatocellular carcinoma (HCC). Ferroptosis has been shown to promote the radiosensitivity of HCC cells, but it remains unclear whether epigenetic regulations function in this process. In this study, we found that the overexpression of METTL3 was associated with poor prognosis.

Combating chemoresistance: Current approaches & nanocarrier mediated targeted delivery.

Chemoresistance, a significant challenge in effective cancer treatment needs clear elucidation of the underlying molecular mechanism for the development of novel therapeutic strategies. Alterations in transporter pumps, oncogenes, tumour suppressor genes, mitochondrial function, DNA repair processes, autophagy, epithelial-mesenchymal transition (EMT), cancer stemness, epigenetic modifications, and exosome secretion lead to chemoresistance. Despite notable advancements in targeted cancer therapies employing both small molecules and macromolecules success rates remain suboptimal due to adverse effects like drug efflux, target mutation, increased mortality of normal cells, defective apoptosis, etc.

Preparation and Application of Nature-inspired High-performance Mechanical Materials.

Natural materials are valued for their lightweight properties, high strength, impact resistance, and fracture toughness, often outperforming human-made materials. This paper reviews recent research on biomimetic composites, focusing on how composition, microstructure, and interfacial characteristics affect mechanical properties like strength, stiffness, and toughness. It explores biological structures such as mollusk shells, bones, and insect exoskeletons that inspire lightweight designs, including honeycomb structures for weight reduction and impact resistance.

DYRK1A-TGF-β signaling axis determines sensitivity to OXPHOS inhibition in hepatocellular carcinoma.

Intervening in mitochondrial oxidative phosphorylation (OXPHOS) has emerged as a potential therapeutic strategy for certain types of cancers. Employing kinome-based CRISPR screen, we find that knockout of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) synergizes with OXPHOS inhibitor IACS-010759 in liver cancer cells. Targeting DYRK1A combined with OXPHOS inhibitors activates TGF-β signaling, which is crucial for OXPHOS-inhibition-triggered cell death.

Advancing siRNA Therapeutics targeting MCT-4: A Multifaceted approach integrating Arithmetical Designing, Screening, and molecular dynamics validation.

Monocarboxylate transporter 4 (MCT-4) is involved in various metabolic processes which are crucial in maintaining cellular pH and energy metabolism, and thus influence the tumor microenvironment. The study is aimed to rationally design effective Small interfering RNA (siRNA) that can silence MCT-4. We utilized a comprehensive workflow integrating multiple tools such as siDirect version 2.

Unprecedented East Siberian wildfires intensify Arctic snow darkening through enhanced poleward transport of black carbon.

Summer Arctic black carbon (BC) predominantly originates from boreal wildfires, significantly contributing to Arctic warming. This study examined the impact of MODIS-detected extensive East Siberian wildfires from 2019 to 2021 on Arctic BC and the associated radiative effects using GEOS-Chem and SNICAR simulations. During these years, Arctic surface BC aerosol concentrations rose to 46 ng m, 43 ng m, and 59 ng m, nearly doubling levels from the low-fire year of 2022.

The droplet dynamics of asymmetrical impingement on moving ridged surface.

Hypothesis: The depth of research into the mechanism of droplet impacting structured surfaces dictates the efficacy of their applications. The impact stress generated when a droplet impacts a surface is a pivotal factor influencing the efficiency of surface applications, ultimately determining the extent of surface wear. Despite the systematic examination of impact force, there remains a scarcity of research on impact stress and its mitigation strategies.

Differentially expressed messenger RNA isoforms in beef cattle skeletal muscle with different fatty acid profiles.

This study aimed to identify mRNA isoforms that were expressed differently in the muscle tissue of Nellore cattle based on their intramuscular fatty acid profile. Forty-eight young bulls were used to quantify beef fatty acids (FA) and perform RNA sequencing analysis. The young bulls were divided into three different groups based on quantifying FA using k-means analysis.

Accelerating electron transfer reduces CH and CO emissions in paddy soil.

As an accelerated electron transfer device, the influence of microbial electrochemical snorkel (MES) on soil greenhouse gas production remains unclear. Electron transport is the key to methane production and denitrification. We found that the NO amount of the MES treatment was comparable to the control however the cumulative CO and CH emissions were reduced by 50% and 41%, respectively.

Creatine monohydrate administration delayed muscle glycolysis of antemortem-stressed broilers by enhancing muscle energy status, increasing antioxidant capacity and regulating muscle metabolite profiles.

Preslaughter stress induced a negative energy balance of broilers, resulted in an accelerated glycolysis and finally led to an inferior meat quality. The present study aimed to investigate the effects of creatine monohydrate (CMH) supplementation on muscle energy storage, antioxidant capacity, the glycolysis of postmortem muscle and the metabolite profiles in muscle of broilers subjected to preslaughter transport. Two hundred and forty broilers were chosen and randomly allocated into three treatments (group A, group B and group C), comprising 8 replicates (10 broilers each replicate).

Synergistically effects of n-3 PUFA and B vitamins prevent diabetic cognitive dysfunction through promoting TET2-mediated active DNA demethylation.

Diabetic cognitive dysfunction (DCD) refers to the cognitive impairment observed in individuals with diabetes. Epidemiological studies have suggested that supplementation with n-3 polyunsaturated fatty acid (PUFA) or B vitamins may prevent the development of diabetic complications. Post hoc studies indicate a potential synergistic effect of n-3 PUFA and B vitamins in preventing cognitive impairment.

Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain.

The brain uses a specialized system to transport cerebrospinal fluid (CSF), consisting of interconnected ventricles lined by motile ciliated ependymal cells. These cells act jointly with CSF secretion and cardiac pressure gradients to regulate CSF dynamics. To date, the link between cilia-mediated CSF flow and brain function is poorly understood.

Deciphering the colostral-immunity transfer: from mammary gland to neonates small intestine.

Colostrum, the initial mammary secretion produced by various mammals following birth, is a conduit for maternal immunity transfer in diverse mammalian species. Concurrently, many cellular processes are occurring in the neonatal small intestine to prepare it to receive molecular signals from a superfood essential for the neonate's health and development. During the prepartum colostrum secretion, the newborn intestine undergoes transient alterations in the intestinal barrier, primarily regulating immunoglobulin absorption.

Rational Design of Dual-Targeted Nanomedicines for Enhanced Vascular Permeability in Low-Permeability Tumors.

Designing dual-targeted nanomedicines to enhance tumor delivery efficacy is a complex challenge, largely due to the barrier posed by blood vessels during systemic delivery. Effective transport across endothelial cells is, therefore, a critical topic of study. Herein, we present a synthetic biology-based approach to engineer dual-targeted ferritin nanocages (Dt-FTn) for understanding receptor-mediated transport across tumor endothelial cells.

Mitochondrial Porin Is Required for Versatile Biocontrol Trait-Involved Biological Processes in a Filamentous Insect Pathogenic Fungus.

The mitochondrial voltage-dependent anion channel (VDAC) is the major channel in the mitochondrial outer membrane for metabolites and ions. VDACs also regulate a variety of biological processes, which vary in the number of VDAC isoforms across different eukaryotes. However, little is known about VDAC-mediated biocontrol traits in biocontrol fungi.

Room-Temperature CsPbI-Quantum-Dot Reinforced Solid-State Li-Polymer Battery.

A novel polymer electrolyte based on CsPbI quantum dots (QDs) reinforced polyacrylonitrile (PAN), named as PIL, is exploited to address the low room-temperature (RT) ion conductivity and poor interfacial compatibility of polymer solid-state electrolytes. After optimizing the content of CsPbI QDs, RT ion conductivity of PIL largely increased from 0.077 to 0.

Multiscale Understanding of Anion Exchange Membrane Fuel Cells: Mechanisms, Electrocatalysts, Polymers, and Cell Management.

Anion exchange membrane fuel cells (AEMFCs) are among the most promising sustainable electrochemical technologies to help solve energy challenges. Compared to proton exchange membrane fuel cells (PEMFCs), AEMFCs offer a broader choice of catalyst materials and a less corrosive operating environment for the bipolar plates and the membrane. This can lead to potentially lower costs and longer operational life than PEMFCs.

Investigating non-target site resistance to pyroxsulam in a glyphosate-resistant Lolium rigidum population.

Background: Resistance to multiple herbicides is common in Lolium rigidum. Here, resistance to acetolactate synthase (ALS)- and susceptibility to acetyl-CoA carboxylase (ACCase)-inhibiting herbicides was confirmed in a glyphosate-resistant L. rigidum population (NLR70) from Australia and the mechanisms of pyroxsulam resistance were examined.

Efficient Catalysis for Zinc-Air Batteries by Multiwalled Carbon Nanotubes-Crosslinked Carbon Dodecahedra Embedded with Co-Fe Nanoparticles.

The design and fabrication of nanocatalysts with high accessibility and sintering resistance remain significant challenges in heterogeneous electrocatalysis. Herein, a novel catalyst is introduced that combines electronic pumping with alloy crystal facet engineering. At the nanoscale, the electronic pump leverages the chemical potential difference to drive electron migration from one region to another, separating and transferring electron-hole pairs.

An Efficient Cluster-Based Mutual Authentication and Key Update Protocol for Secure Internet of Vehicles in 5G Sensor Networks.

The Internet of Vehicles (IoV), a key component of smart transportation systems, leverages 5G communication for low-latency data transmission, facilitating real-time interactions between vehicles, roadside units (RSUs), and sensor networks. However, the open nature of 5G communication channels exposes IoV systems to significant security threats, such as eavesdropping, replay attacks, and message tampering. To address these challenges, this paper proposes the Efficient Cluster-based Mutual Authentication and Key Update Protocol (ECAUP) designed to secure IoV systems within 5G-enabled sensor networks.

Delay/Disruption Tolerant Networking Performance Characterization in Cislunar Relay Communication Architecture.

Future 7G/8G networks are expected to integrate both terrestrial Internet and space-based networks. Space networks, including inter-planetary Internet such as cislunar and deep-space networks, will become an integral part of future 7G/8G networks. Vehicle-to-everything (V2X) communication networks will also be a significant component of 7G/8G networks.