Green synthetic sodium alginate-glycerol-MXene nanocomposite membrane with excellent flexibility and mineralization ability for guided bone regeneration.

Developing a novel bioactive material as a barrier membrane for guided bone regeneration (GBR) surgery remains challenging. As a new member of two-dimensional (2D) material family, MXene is a promising candidate component for barrier membranes due to its high specific surface area and osteogenic differentiation ability. In this work, a green and simple SA/glycerol/MXene (SgM) composite membrane was prepared via solvent casting method by using sodium alginate (SA) and MXene (M) as raw materials while employing glycerol (g) as a plasticizer.

Protective effect of rapamycin in models of retinal degeneration.

Age-related macular degeneration (AMD) is a complex retinal disease with no viable treatment strategy. The causative mechanistic pathway for this disease is not yet clear. Therefore, it is highly warranted to screen effective drugs to treat AMD.

Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes.

Alkali burn to the cornea is one of the most intractable injuries to the eye due to the opacity resulting from neovascularization (NV) and fibrosis. Numerous studies have focused on studying the effect of drugs on alkali-induced corneal injury in mouse, but fewer on the involvement of alkali-induced DNA methylation and the PI3K/AKT/mTOR signaling pathway in the mechanism of alkali-induced corneal injury. Thus, the aim of this study was to determine the involvement of DNA methyltransferase 3 B-madiated DNA methylation and PI3K/AKT/mTOR signaling modulation in the mechanism of alkali-induced corneal injury in a mouse model.

A comparative study of three palatoplasty techniques in wide cleft palates.

The aim of this study was to clinically evaluate the effectiveness of various palatoplasty techniques for the repair of cleft palates greater than 8mm in width. This prospective cohort study included 142 patients with complete cleft palate between September 2017 and January 2019. Among the patients, 60 underwent a modified palatoplasty with Furlow Z-plasty (MPFZP), 51 underwent a von Langenbeck (VL) repair, and 31 underwent a two-flap palatoplasty (2FP).

Anti-atherosclerosis effect of HS donors based on nicotinic acid and chlorfibrate structures.

Based on the structures of nicotinic acid and chlorfibrate, a series of new HS donors were synthesized and their anti-atherosclerosis activities using Ox-LDL RAW 264.6 cells as model were evaluated. The release test showed that all the compounds could release HS effectively and showed low cytotoxicity.

The influence of the negative ion powder on the properties of alginate impression materials.

This paper investigated the effects of different contents of negative ion powder on the antibacterial activity and mechanical properties of the alginate impression materials. The cytotoxicity of the negative ion powder was evaluated. The antibacterial rate was evaluated by the plate count method, and the mechanical properties, including the gelation time, elastic recovery, compressive strain and compressive strength were characterized by standards method.

[Application of intraoperative CT in oral and maxillofacial surgery].

With the introduction of the concept of precision surgery and the development of modern compound operating rooms, intraoperative computerized tomography (ICT) came into being. Due to the multidisciplinary nature of ICT, its use in oral and maxillofacial surgery has also been increasing in recent years. This article describes the application of ICT in oral and maxillofacial trauma, orthognathic surgery, and craniofacial tumor treatment, and analyzes its advantages and limitations.

Synthesis, toxicities and bio-activities of manganese complexes with CO and HS dual donors.

A series of HSCO dual-donors [Mn(CO)CSNRR] was synthesized, and evaluated from toxicity and bioactivity. The COHS measuring test showed all the complexes not only released CO, but released HS. The resulting data of cytotoxicity showed all the complexes had activities against the cell proliferation; among them, complexes 1, 2 and 7 displayed higher activities than the others, and their potencies were close to cis-platinum (DDP); whereas the precursors A-A had almost no activities against all five tumor cell lines and W138 cell line proliferation.

Syntheses, toxicities and anti-inflammation of HS-donors based on non-steroidal anti-inflammatory drugs.

Three series of HS donors based on NSAIDs were synthesized and characterized by H-NMR, IR and ESI-HRMS. The HS-release abilities of all compounds were evaluated in the presence of TECP or cysteine. The results show all compounds were fast HS-releasers, and their half-lives were in range of 0-20 min.

Toxicity, bio-distribution and metabolism of CO-releasing molecules based on cobalt.

CO-releasing molecules (CORMs) containing [Co2(CO)6] moiety show many bioactivities, such as anti-inflammatory and antitumor cell proliferation. However, so far, no one knows their properties in vivo. So, here, we evaluated some these kind CORMs from drug-like properties including cytotoxicity, toxicity in vivo, distribution and metabolism.

Syntheses and evaluation of drug-like properties of CO-releasing molecules containing ruthenium and group 6 metal.

In this paper, drug-like properties of two series of carbonyl metal CO-releasing molecules, Ru(CO)₃Cl(n)L (n=1, L=amino acid or its derivatives 1-7, L=acetylacetone 8 or 2,2'-bipyridyl 9; n=2, L=aminopyridine derivatives 10-13; n=0, L=salicylaldehyde Schiff base 14-15) and M(CO)₅L(M=Cr, Mo, W; L=glycine methyl ester 16-18; L=N-methyl imidazole 19-21), were preliminarily evaluated from four aspects involving in cytotoxicity, in vivo toxicity, bio-distribution and metabolism. Cytotoxic effects of all complexes were assayed by MTT. IC₅₀ values of complexes 1-15 were 39.