2 results match your criteria: "School of Stomatology Zhengzhou University[Affiliation]"
14-3-3ζ silencing retards tongue squamous cell carcinoma progression by inhibiting cell survival and migration.
Cancer Gene Ther
July 2016
Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Our study aimed to investigate the isoform-specific distribution of 14-3-3 in tongue squamous cell carcinoma (TSCC) and their association with cancer progression, and to further discuss their roles in cancer cell survival. In this study, 42 TSCC specimens and their matched normal para-carcinoma sections were collected. The immunohistochemistry analysis identified that 14-3-3σ and ζ isoforms presented significantly higher expression in cancerous tissues compared with the matched normal tongue tissue sections.
View Article and Find Full Text PDF14-3-3ζ regulates immune response through Stat3 signaling in oral squamous cell carcinoma.
Mol Cells
November 2015
School of Stomatology Zhengzhou University, Zhengzhou 450052, China.
Article Synopsis
- Ectopic expression of the protein 14-3-3ζ is found in various cancers, including oral squamous cell carcinoma (OSCC), but its role in tumor-immune system interactions has not been previously studied.
- 14-3-3ζ knockdown in OSCC cells increased the expression of inflammatory cytokines, while introducing 14-3-3ζ decreased these cytokines in normal cells stimulated by inflammatory agents.
- The protein 14-3-3ζ interacts with Stat3, and disrupting this interaction alleviates the inhibitory effects of 14-3-3ζ on tumor inflammation, suggesting it may play a crucial role in modulating tumor inflammation and the immune response in OSCC.