The Role of Exercise in Regulating the Generation of Extracellular Vesicles in Cardiovascular Diseases.

Extracellular vesicles (EVs) are nanoscale vesicles released by cells, which play an important role in intercellular communication by transporting proteins, lipids, nucleic acids, and other molecules. Different intensities of exercise can induce the release of EVs from cells and tissues, such as endothelial cells, skeletal muscle and adipose tissue, hepatocytes, immune cells, and neuronal cells. Exercise-induced EVs exert cardiovascular protective effects such as anti-inflammatory and anti-oxidative by altering their contents.

Evaluation of Acoustic Voice Quality Index in Persian-Speaking Parkinson's Patients Compared to Healthy Controls and Its Association With Disease Severity Based on UPDRS-III and Dysarthria Severity.

Introduction: Parkinson's patients with dysarthria often suffer from multiple impairments in speech subsystems, including phonation. The Acoustic Voice Quality Index (AVQI) may be considered as a predictor of the onset and severity of Parkinson's disease.

Objective: Investigating the AVQI in Persian-speaking Parkinson's patients compared to healthy controls and its association with disease severity based on Unified Parkinson's Disease Rating Scale-Part III (UPDRS-III) and dysarthria severity.

Ankle-hip joint trade-off in normal gait: Exploring the kinematic influence of the medial longitudinal arch of the foot.

Background: In human gait, leg progression into the swing phase involves two primary strategies: ankle plantar flexion and hip flexion. These strategies are believed to exhibit a trade-off relationship; however, it is unclear whether this relationship holds for normal gait and the role of the medial longitudinal arch (MLA) in shaping these strategies.

Research Questions: Does a trade-off relationship exist between ankle plantar flexion and hip flexion strategies during normal gait in young healthy adults? Do the kinematics of MLA during gait influence the strategies during leg progression into the swing phase?

Methods: Data from 36 young healthy adults were analyzed.

Successful Strategies for Occupational Health and Safety in Small and Medium Enterprises: Insights for a Sustainable Return to Work.

Purpose: The objectives of this paper were to summarize successful strategies in occupational health and safety (OHS) management in small and medium-sized enterprises (SMEs) and to explore their potential applicability for disability management (DM) and return-to-work (RTW) after work-related injuries.

Methods: A scoping review was conducted, using a consensus-based iterative approach, and a consultation with stakeholders. Twelve databases were searched in collaboration with a specialized librarian, using keywords and combinations of terms.

Bone loss in patients with spinal cord injury: Incidence and influencing factors.

Purpose: To investigate the incidence and influencing factors of bone loss in patients with spinal cord injury (SCI).

Methods: A retrospective case-control study was conducted. Patients with SCI in our hospital from January 2019 to March 2023 were collected.

Virtual Assessment Protocols for Timed-Up-and-Go, 5-Repetition Chair Rise, and 1-Minute Sit-to-Stand Tests in Community-Dwelling Older Adults: Investigating Feasibility, Reliability, and Validity.

Objective: To develop and evaluate virtual assessment protocols for the Timed-Up-and-Go usual and fast pace, Chair Rise-5 repetition, and the 1-minute Sit-to-Stand tests and examine their feasibility, reliability, and validity.

Design: This was a prospective cohort study, where participants engaged in up to 2 virtual assessments and data were collected prospectively for 1 year.

Setting: Assessments took place in participants' homes in the community.

Acceptability of physiotherapists as primary care practitioners for the care of people with musculoskeletal disorders: a French population-based cross-sectional survey.

Objectives: In France, early access to physiotherapy for people with musculoskeletal disorders (MSKDs) depends on prescription and referral by the family physician in the physician-led model of care. The readiness of French people for direct access to physiotherapy is not known. This survey aims to identify the perceptions of French adults regarding physiotherapists' competence to diagnose and manage MSKDs if they were primary care practitioners, confidence in their ability to provide quality care, and satisfaction with the last episode of care for those concerned; and to identify factors associated with these three variables.

A novel aggregation-induced emission-featured hyperbranched poly(amido amine)s stabilized copper nanoclusters‑cerium (III) sensor for detection of thiol flavor compounds in processed meat.

Thiol flavor compounds are a class of flavoring ingredients that contribute significantly to food flavor. However, rapid discrimination of multiple thiol-flavor compounds remain a challenge. In this study, a ratiometric fluorescent sensor (TPE-ssHPA@Cu NCs-Ce) with dual-channel fluorescence features was developed using tetraphenylethene-embedded hyperbranched poly(amidoamine) as a template to stabilize the copper nanocluster‑cerium ions.

Safety and Feasibility of Early Activity-Based Therapy Following Severe Traumatic Spinal Cord Injury: Results from a Single-Arm Pilot Trial.

Early activity-based therapy (E-ABT) has the potential to decrease complications and radically improve neurofunctional recovery following traumatic spinal cord injury (TSCI). Unfortunately, E-ABT after TSCI has never been attempted in humans due to practical obstacles and potential safety concerns. This study aims to report on the safety and feasibility outcomes of the Protocol for Rapid Onset of Mobilization in Patients with Traumatic SCI (PROMPT-SCI) trial: the first-ever trial of E-ABT in critically ill patients who suffered a severe TSCI.

Being and Doing Together in a Naturally Occurring Retirement Community: Pandemic Experiences of Older Adults.

Developing effective, sustainable strategies that promote social inclusion, reduce isolation, and support older adults' wellbeing continues to be important to aging communities in Canada. One strategy that targets community-living older adults involves identifying naturally occurring retirement communities (NORCs) and supporting them through supportive service programs (NORC-SSPs). This qualitative descriptive study utilized semi-structured interviews to explore how older adults living in a NORC supported by an SSP, sought to build, and maintain, a sense of community during the COVID-19 pandemic.

Single high-frequency repetitive transcranial magnetic stimulation and intermittent theta pulse stimulation promote working memory behavior in participants: An event-related potential study.

Objective: Repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (L-DLPFC) has an improving effect in cognitive function, but it is still not clear in what specific cognitive domains. We here combined a single session of TMS (HF-rTMS/iTBS) with electroencephalography (EEG) to clarify the effects of magnetic stimulation techniques on executive function, working memory, and visuospatial attention in healthy participants, and to investigate the underlying neurophysiological mechanisms.

Methods: Fifty-one healthy participants were randomly assigned to three stimulation groups (HF-rTMS, iTBS, and sham groups).

Follow-up in low vision rehabilitation for users of assistive technology: a scoping review.

Assistive technology (AT) is crucial for aiding activities of daily living in individuals with visual impairment; yet, without systematic follow-up device abandonment rates remain high. This scoping review synthesizes existing literature on follow-up processes in individuals with visual impairment undergoing vision rehabilitation with AT. Employing the Arksey and O'Malley framework, this review comprehensively searched seven databases, identifying 1,061 articles, of which 43 were selected for analysis, using the concepts of and The publications span from 1989 to 2022.

The lasting influence of parenting intervention on child behavior: findings from a randomized clinical trial using care for child development guidelines.

Background: Studies have investigated the role of different parenting intervention programs in the early development of children. Here we aimed to determine the long-term efficacy of Care for Child Development (CCD) guideline interventions on behavioral dimensions of children's development.

Methods: This randomized clinical trial took place at an outpatient public Pediatrics clinic in Isfahan, Iran from February 2020 to May 2024.

Effect of Transferrin-Modified FeO Nanoparticle Targeted Delivery miR-15a-5p Combined With Photothermal Therapy on Lung Cancer.

Background: Existing studies have shown that transferrin receptor (TfR) is highly expressed on the surface of lung cancer cells, and nanoparticles (NPs) have been widely used as delivery vehicles. The aim of this study was to investigate the effect of the targeted delivery of FeO NPs modified with transferrin (Tf) compared with photothermal treatment for lung cancer.

Methods: The morphology and properties of Fe3O4 NPs modified with Tf were tested by internal morphological characterization experiments including transmission electron microscopy, particle size meter infrared spectrometer and other experiments.

Interventions for the management of long covid (post-covid condition): living systematic review.

Objective: To compare the effectiveness of interventions for the management of long covid (post-covid condition).

Design: Living systematic review.

Data Sources: Medline, Embase, CINAHL, PsycInfo, Allied and Complementary Medicine Database, and Cochrane Central Register of Controlled Trials from inception to December 2023.

Evaluation of the Staff Educational Components of the PROMOTE Program to Improve Resident Hydration.

Background/objectives: Inadequate fluid intake is prevalent among older adults living in care settings and can lead to dehydration-related events such as falls and hospitalization. Staff knowledge and confidence using diverse strategies is needed to provide adequate hydration to residents. PROMOTE is a multicomponent intervention designed to support staff to increase resident fluid intake between meals.

Cajaninstilbene Acid and Its Derivative as Multi-Therapeutic Agents: A Comprehensive Review.

Pigeon pea ( (L.) Millsp.) is a traditional Chinese medicinal plant widely utilized in folk medicine due to its significant pharmacological and nutritional properties.

Effects of muscle contraction induced by electrical stimulation on fascial gliding: Evaluation by ultrasonography.

Purpose: This study investigates the effects of neuromuscular electrical stimulation (NMES)-induced muscle contraction on fascial gliding between the muscle and adjacent tissues and identifies factors that affect fascial gliding.

Methods: The gliding between the epimysium of the vastus lateralis muscle and the subcutaneous tissue was measured using a diagnostic ultrasound system during the subject's knee joint was flexed passively. The deep temperature, deep blood flow, and tissue hardness of the vastus lateralis muscle were measured to identify factors contributing to the changes in fascial gliding.

Investigating cervical flexion-relaxation ratio in subjects with cervical lateral spinal stenosis compared with asymptomatic controls: A case control study.

Introduction: The cervical flexion-relaxation ratio (FRR) is known as a quantitative measure of the ability of the cervical extensor muscles to relax during the full flexion of the cervical spine. Compared with subjects suffering from non-specific neck pain, the changes occurring in the pattern of the neck muscles' functions in cases with cervical spinal stenosis are not yet well understood. Therefore, this study aimed to compare cervical FRR in subjects with cervical lateral spinal stenosis and asymptomatic controls.