Reliability and minimal detectable change of the MX3 hydration testing system.

Assessing hydration status outside of laboratories can be challenging given that most hydration measures are invasive, stationary, costly, or have questionable validity. This study investigated the within-day, test-retest reliability, and minimal detectable change (MDC) of the MX3 Hydration Testing System (MX3 Diagnostics), a relatively low cost, noninvasive, and portable method to measure saliva osmolality. Seventy-five adults (44 men, 31 women; 29.

Glucocorticoid facet joint injection for chronic back or neck pain.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: The primary objective is to assess the benefits and harms of glucocorticoid facet joint injections in adults with chronic back or neck pain that is presumed to be facet joint-mediated. The secondary objective is to assess whether the effects differ by diagnostic method for facet joint-mediated pain.

Altingia chinensis petroleum ether extract suppresses NSCLC via induction of apoptosis, attenuation of EMT, and downregulation of PI3K/Akt pathway.

Background: Non-small-cell lung cancer (NSCLC) is the primary type of lung cancer with the leading cause of fatalities from cancer, and the effective treatment is minimal. Altingia chinensis is a medicinal plant utilized as a traditional folk remedy to alleviate rheumatism, punch injury and paralysis. APE is the petroleum ether extract from A.

Wearable EEG Neurofeedback Based-on Machine Learning Algorithms for Children with Autism: A Randomized, Placebo-controlled Study.

Objective: Behavioral interventions have been shown to ameliorate the electroencephalogram (EEG) dynamics underlying the behavioral symptoms of autism spectrum disorder (ASD), while studies have also demonstrated that mirror neuron mu rhythm-based EEG neurofeedback training improves the behavioral functioning of individuals with ASD. This study aimed to test the effects of a wearable mu rhythm neurofeedback training system based on machine learning algorithms for children with autism.

Methods: A randomized, placebo-controlled study was carried out on 60 participants aged 3 to 6 years who were diagnosed with autism, at two center-based intervention sites.

Differential modulation of pain and associated anxiety by GABAergic neuronal circuits in the lateral habenula.

Persistent pain frequently precipitates the development of anxiety disorders, yet the underlying mechanisms are not fully understood. In this study, we employed a mouse model that simulates trigeminal neuralgia and observed a marked reduction in the activity of GABAergic neurons in the lateral habenula (LHb), a critical region for modulating pain and anxiety. We utilized precise optogenetic and chemogenetic techniques to modulate these neurons, which significantly alleviated behaviors associated with pain and anxiety.

Microenvironment-optimized gastrodin-functionalized scaffolds orchestrate asymmetric division of recruited stem cells in endogenous bone regeneration.

The regeneration of osteoporotic bone defects remains challenging as the critical stem cell function is impaired by inflammatory microenvironment. Synthetic materials that intrinsically direct osteo-differentiation versus self-renewal of recruited stem cell represent a promising alternative strategy for endogenous bone formation. Therefore, a microenvironmentally optimized polyurethane (PU) /n-HA scaffold to enable sustained delivery of gastrodin is engineered to study its effect on the osteogenic fate of stem cells.

A comprehensive evaluation tool to assess community capacity and readiness for virtual care implementation.

Introduction: The rapid evolution and implementation of virtual care technologies for clinical use often exceeds the development of standardized implementation protocols, leading to gaps in the equitable and sustainable adoption of virtual care services, particularly in rural and remote areas. This paper introduces a comprehensive evaluation tool designed to assess community capacity and readiness for virtual care.

Methods: The development of the tool was informed by experiences from the Virtual Care and Robotics Program at the University of Saskatchewan.

The influencing factors for tracheostomy decannulation after traumatic cervical spinal cord injury: a retrospective study.

Study Design: Retrospective study.

Objective: To investigate the outcomes and influencing factors of tracheostomy decannulation (TD) in persons with traumatic cervical spinal cord injury (SCI).

Setting: China Rehabilitation Research Center (CRRC) in Beijing, China.

Differences in brain activation and connectivity during unaffected hand exercise in subacute and convalescent stroke patients.

Patients experiencing severe hemiplegia following a stroke struggle to rehabilitate their affected limbs. Cross-education (CE) training emerges as a promising rehabilitation method due to its safety, simplicity, low risk, and ability to effectively improve muscle strength in the affected limb. However, controversy surrounds the neural mechanisms and clinical applications of CE.

Practice Trends for Hearing Aid Fitting for Adults Among Audiologists in India: A Survey.

Audiologists are hearing healthcare specialists dedicated to the rehabilitation of individuals with hearing loss by prescribing the appropriate amplification devices. The process of choosing and fitting hearing aids involves several steps for which standardized guidelines have been issued. The aim of the present investigation was to evaluate the patterns of practice employed by Indian audiologists in the evaluation and fitting of hearing aids for adults.

Effect of Simultaneous Use of Neuromodulation and Acoustic Stimulation in the Management of Tinnitus.

Tinnitus is a relatively common disorder with a heterogeneous nature. Combining methods in its treatment may offergreater effectiveness. We aim to explore the impact of concurrently applying tRNS neuromodulation and acousticstimulation for tinnitus control.

Physiotherapists as first-contact practitioners for patients with low back pain in French primary care: a pragmatic cluster randomised controlled trial.

Background: A new model of care enables French physiotherapists (PT) working in collaboration with family physicians (FP) to expand their usual scope of practice for patients with acute low back pain (LBP). The aim of our study is to evaluate the impact of this new first-contact physiotherapy (FCP) advanced practice model compared to usual FP care.

Methods: A multicentre pragmatic non-inferiority cluster randomised controlled trial (RCT) has been conducted in six multidisciplinary primary healthcare centres in France.

[Progress of experimental research on the underlying mechanisms of acupuncture in improving chronic obstructive pulmonary disease].

Chronic obstructive pulmonary disease (COPD) is a common disease that seriously jeopardizes human health and affects patients' quality of life. The clinical efficacy of acupuncture in treating COPD is definite, and it can exert positive effects such as improving skeletal muscle degradation, airway mucus hypersecretion and pulmonary vascular remodeling in COPD rats. In recent years, the research on the underlying mechanisms of acupuncture in improving COPD has become more and more in-depth.

[Electroacupuncture reduces neuronal apoptosis in rats with spinal cord injury by regulating GSK-3β expression and its phosphorylation].

Objectives: To observe the effect of electroacupuncture (EA) stimulation of "Dazhui"(GV14) and "Mingmen" (GV4) of the Governor Vessel (GV) on the apoptosis of neurons in rats with spinal cord injury (SCI) by regulating the expression of glycogen synthase kinase-3β (GSK-3β) protein and its phosphorylation level, so as to reveal partial mechanism for the treatment of SCI with EA of GV.

Methods: A total of 45 male SD rats were randomly divided into sham-operation, model and EA groups, 15 rats in each group. The SCI model was established by using the modified Allen's percussion device.

Salidroside ameliorates neuroinflammation in autistic rats by inhibiting NLRP3/Caspase-1/GSDMD signal pathway.

Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that place a huge economic and emotional burden on society. Salidroside (Sal) has been reported to have therapeutic effects in a variety of neurological disorders such as Alzheimer's disease （AD） and Parkinson's disease (PD), however no studies have been conducted to show whether salidroside is effective in ASD. Pyroptosis is involved in the pathology of a variety of neurological disorders, but has not been reported in ASD.

Exploring the Molecular Interaction Between NR2E3 and NR1D1 in Retinitis Pigmentosa: A Docking and Molecular Dynamics Study.

Background And Aims: Retinitis pigmentosa (RP) is a hereditary retinal disorder that gradually leads to vision loss due to photoreceptor cell degeneration. This study aims to investigate the clinical features and genetic underpinnings of RP within a large Iranian family. Our focus centered on mutations in the NR2E3 gene, which plays a critical role in the development and maintenance of the retina.

The biocompatibility of gallium-based liquid metals with blood and serum.

Excellent biocompatibility of liquid metals is the basis for developing biomedical applications, such as implantable devices, drug delivery, and tumor therapy. Especially, a systematic study to reveal the influence of gallium-based liquid metals on the composition of blood while they are used in the human body is vital but missing. Here, the compatibility of three kinds of frequently used gallium-based liquid metals with human blood and serum was explored systematically.

UHPLC-Q-Orbitrap HRMS and network analysis to explore the mechanisms of QiShenYiQi dripping pill for treating myocardial infarction.

This study focused on examining the protection of QiShenYiQi dripping pills (QSYQ) against myocardial infarction (MI) and investigating its potential mechanisms. Ultra high performance liquid chromatography-q exactive-orbitrap high resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) was employed to analyze potential active compounds of QSYQ. The targets of these compounds were predicted using an integrated method and cross-referenced with relevant databases to identify associated pathways.

Responsiveness of the P4, Patient Specific Functional Scale 2.0, Satisfaction and Recovery Index, and SF-12 in Patients With Musculoskeletal Disorders.

Background Recently, estimation of intervention effects has been recommended using minimum important change (MIC). This study aimed to investigate the responsiveness of the four-item pain intensity measure (P4), Patient Specific Functional Scale 2.0 (PSFS 2.