231 results match your criteria: "School of Radiology[Affiliation]"

Background And Purpose: Quantifying tumor heterogeneity from various dimensions is crucial for precise treatment. This study aimed to develop and validate multi-omics models based on the computed tomography images, pathological images, dose and clinical information to predict treatment response and overall survival of non-small cell lung cancer (NSCLC) patients undergoing chemotherapy and radiotherapy.

Materials And Methods: This retrospective study included 220 NSCLC patients from three centers.

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Alterations of subcortical structural volume in pediatric bipolar disorder patients with and without psychotic symptoms.

Psychiatry Res Neuroimaging

January 2025

Department of Child Psychology, The Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, National Children's Regional Medical Center, Hangzhou, Zhejiang, China. Electronic address:

Background: Pediatric bipolar disorder (PBD) with psychotic symptoms may predict more severe impairment in social functioning, but the underlying biological mechanisms remain unclear. The aim of this study was to investigate alterations in subcortical structural volume in PBD with and without psychotic symptoms.

Methods: We recruited 24 psychotic PBD (P-PBD) patients, 24 non-psychotic PBD (NP-PBD) patients, and 18 healthy controls (HCs).

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Glucose transporter type 1 deficiency syndrome (GLUT1-DS) is an uncommon condition represented by an infantile-onset disorder, frequently arising from heterozygous mutations in the gene. Individuals with GLUT1-DS may present with early-onset seizures (typically manifesting before 4 years of age), developmental delay, and complex movement disorders. In fewer cases, stroke-like events or hemiplegic migraine-like symptoms are also reported, defined by unilateral paresis affecting 1 side of the body and/or one-half of the face, occasionally accompanied by speech impairment.

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Background: Lymphedema represents a frequent cause of disability for patients undergoing oncological treatments and, being a chronic, non-reversible pathology, requires targeted and continuous rehabilitation treatments. To date, the studies available on the use of ultrasound in patients with lymphedema mainly report descriptive data; therefore, with this study, we wanted to describe in a more objective way the typical ultrasound alterations found in these patients, measuring the thickness of the different superficial structures, and defining subcutis echogenicity.

Methods: 14 patients affected by secondary lymphedema of the upper limbs were enrolled in this cross-sectional observational study (12 had breast cancer and 2 with melanoma as their primary diagnosis).

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Computed tomography plays an ever-increasing role in the management of fractures and dislocations due to its capability in efficiently providing multiplanar reformats and 3-dimensional volume rendered images. It can reveal findings that are occult on plain radiography and therefore allow for more accurate decision making with regard to fracture classification and management. Clinical radiologists play a critical role in facilitating the processing of imaging to provide adequate image reformats in the desired planes, producing 3 dimensional images but most crucially identifying pertinent findings, which will contribute between the selection of nonoperative and operative management and potentially influence surgical technique.

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Diabetes mellitus (DM) is one of the most prevalent cardiovascular risk factors in the general population, being associated with high morbidity and socioeconomic burden. Diabetic cardiomyopathy (DCM) is a non-negligible complication of DM, whose pathophysiological fundaments are the altered cardiac metabolism, the hyperglycemia-triggered formation of advanced glycation end-products (AGEs) and the inflammatory milieu which are typical in diabetic patients. These metabolic abnormalities lead to cardiomyocytes apoptosis, interstitial fibrosis and mechanical cardiac dysfunction, which can be identified with non-invasive imaging techniques, like echocardiography and cardiac magnetic resonance.

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Background And Purpose: Autism spectrum disorder (ASD) is clinically heterogeneous, and resent neuroimaging studies have shown the presence of brain structural heterogeneity in ASD. However, there is currently a lack of evidence for systemic level brain structural heterogeneity. This study aimed to reveal the heterogeneity of brain structural changes at the systemic level in ASD patients through individual differential structural covariance network (IDSCN) analysis.

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Background/objectives: Lymphedema, a common source of disability among oncology patients, necessitates continuous targeted rehabilitation. Recent studies have revealed the role of connective tissue in this pathology; however, despite existing research on ultrasound (US) use in lymphedema, no studies have specifically addressed the use of ultrasound to assess fasciae in patients with lymphedema. This study aims to provide a more objective characterization of typical US alterations in these patients by quantifying the thickness of superficial and deep fasciae and comparing them with those of healthy volunteers.

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Achieving theranostic probes targeting BRD3/BRD4 for imaging and therapy of tumor.

Eur J Med Chem

February 2025

Department of Medicinal Chemistry, School of Pharmacy, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China. Electronic address:

The BET family proteins play pleiotropic roles in the tumorigenesis and growth of various human malignancies that have aroused great interests as the cancer therapeutic targets. Therefore, it's significant to develop labeling toolkits for the dynamic monitoring of BET family proteins in living tumor cells and tissue slices. In particular, there are few small-molecule fluorescent probes based on BET family proteins developed for real-time imaging of these proteins in tumor cells and tissues and treatment of breast cancer.

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Iliac artery aneurysms (IAA) associated with abdominal aortic aneurysms (AAA) are found in 10%-20% of AAAs. Isolated internal iliac artery aneurysms (IIAAs) are an uncommon entity, representing 0.3%-0.

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Introduction Sarcopaenia has been examined as a predictor of frailty in surgical patients and may predict mortality. The hypothesis of this study is that sarcopaenia is associated with an increased risk of death following an episode of acute lower gastrointestinal bleeding (ALGB). Methods This study included patients admitted with ALGB between January 2017 and June 2022, who underwent cross-sectional imaging (CSI).

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Electronic band structure modulation for sonodynamic therapy.

J Mater Chem B

December 2024

Medical Science and Technology Innovation Center, Shandong Provincial Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China.

Sonodynamic therapy (SDT) is a burgeoning and newfangled therapy modality with great application potential. Sonosensitizers are essential factors used to ensure the effectiveness of SDT. For the past few years, a lot of scientists have discovered many valid ways to refine and improve the performance of SDT.

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A Stretchable Conductive Material with High Fatigue Resistance for Strain Sensors.

ACS Appl Mater Interfaces

November 2024

Institute of Medical Engineering and Interdisciplinary Research, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China.

Intrinsically stretchable conductive materials based on elastic substrates and conductive components play important roles in biomedical applications, such as exercise rehabilitation monitoring and disease prediction. A persistent challenge is to combine high fatigue resistance with excellent mechanical properties in stretchable conductive materials. Herein, we present a stretchable conductive material with both good fatigue resistance and high tensile properties (∼3170%) based on poly(acrylic acid)-phytic acid-trehalose-polypyrrole (denoted as PPTP).

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Recent Advances in Silica-Based Nanomaterials for Enhanced Tumor Imaging and Therapy.

ACS Appl Bio Mater

November 2024

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing 211816, China.

Article Synopsis
  • * The review covers the latest advancements in using these nanomaterials for various imaging techniques (like MRI and PET) and therapeutic methods (including chemotherapy and immunotherapy).
  • * It also evaluates the safety and breakdown of these nanomaterials in biological systems, discussing the challenges and future prospects for their clinical use in cancer diagnostics and personalized treatment.
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Alterations of subcortical structure volume in pediatric bipolar disorder patients with manic or depressive first-episode.

BMC Psychiatry

November 2024

Department of Child Psychology, The Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, National Children's Regional Medical Center, No. 3333 Binsheng Road, Hangzhou, 310003, Zhejiang, China.

Background: Bipolar disorder may begin as depression or mania, which can affect the treatment and prognosis. The physiological and pathological differences among pediatric bipolar disorder (PBD) patients with different onset symptoms are not clear. The aims of the present study were to investigate subcortical structural alterations in PBD patients with first-episode depressive (PBD-FED) and first-episode manic (PBD-FEM).

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The efficient synthesis of the pyrrolo[4,3,2-]quinoline core of the lymphostin family (compound ) has been accomplished in 7 steps and 18.6% overall yield, providing an efficient method for the total synthesis and structural modification of the lymphostin family. Compound showed potent inhibitory activities against PI3K/mTOR in the nanomolar range and activity against human colorectal cancer cell lines comparable to that of oxaliplatin, which could be recognized as a novel lead compound for cancer therapy.

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Article Synopsis
  • Acute myocardial infarction (AMI) is a major global health issue, and the study examines the immune cell differences between STEMI (ST-segment elevation) and NSTEMI (non-ST-segment elevation) types, impacting patient outcomes.
  • Data was analyzed using the Sequence Read Archive to identify differentially expressed genes (DEGs) related to immune responses, revealing significant immune cell differences including activated dendritic cells and various T cells.
  • A total of 21 immune-related DEGs were identified, such as CCL18 and IL33, which correlated with immune cell types and could provide valuable insights for improving AMI treatment strategies.
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Background: Applications of artificial intelligence (AI) in medical ultrasound have rapidly grown in recent years. Therefore, it is necessary to identify and visualize global research trends and hotspots of AI in medical ultrasound to provide guidance for further exploitation.

Objective: This study aims to highlight the global research trends and hotspots of the top 100 most-cited papers related to AI in medical ultrasound by combining quantitative and visualization methods.

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Article Synopsis
  • * The nanomedicine (vMnAs@HR) combines virus-like manganese-arsenic nanoparticles with a temporary protein corona to enhance targeting and safety when introduced into the bloodstream.
  • * Once at the tumor site, the protein corona is shed, improving uptake by macrophages and triggering immune responses, while the nanoparticles assist in effective arsenic delivery for enhanced cancer treatment.
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Traumatic injuries continue to be on the rise globally and with it, the role interventional radiology (IR) has also expanded in managing this patient cohort. The role of damage control surgery (DCS) has been well established in the trauma management pathway, however it is only recently that Damage Control IR (DCIR) has become increasingly utilized in managing the extremis trauma and emergency patient.Visceral artery embolizations (both temporary and permanent), temporary balloon occlusions including Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in iliac arteries and aorta respectively are amongst the treatment options now available for the trauma (and non-traumatic bleeding) patient.

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Article Synopsis
  • Researchers have focused on fascias in recent years, particularly their anatomy and related diseases, using advanced imaging techniques like ultrasound (US) and MRI for better insights.
  • This study aimed to evaluate the effectiveness of using US-guided core needle biopsy to sample fascial tissues from various regions in cadavers, assessing visibility, accuracy, and the reliability of needle placements.
  • Results showed that US-guided biopsies are consistent and reliable, successfully capturing high-quality tissue samples, which could aid in diagnosing conditions like eosinophilic fasciitis.
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Objective: To develop an ensemble machine learning (eML) model using multiphase computed tomography (MPCT) for distinguishing between gastric ectopic pancreas (GEP) and gastric stromal tumors (GIST) in lesions < 3 cm.

Methods: In this study, we retrospectively collected MPCT images from 138 patients between April 2017 and June 2023 across two centers. Cohort 1 comprised 94 patients divided into a training cohort and an internal validation cohort, while the 44 patients from Cohort 2 constituted the external validation cohort.

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Objective: Symptomatic carotid artery disease is indicative of an elevated likelihood of experiencing a subsequent stroke, with the morphology of plaque and its specific features being closely linked to the risk of stroke occurrence. Our study based on the characteristics of carotid plaque assessed by optical coherence tomography (OCT), the plaque morphology evaluated by digital subtraction angiography (DSA) and clinical laboratory indicators were combined, develop a combined predictive model to identify symptomatic carotid plaque.

Methods: Patients diagnosed with carotid atherosclerotic stenosis who underwent whole-brain DSA and OCT examination at the Affiliated Hospital of Jining Medical University from January 2021 to November 2023 were evaluated.

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Article Synopsis
  • The study aimed to evaluate how well Pulmonary Perfused Blood Volume (PBV) measurements from Dual-Energy CT (DECT) correlate with Lung Perfusion Scintigraphy (LPS) in patients with moderate to severe Pulmonary Emphysema (PE).
  • Significant but weak correlations were found between PBV and LPS in certain lung regions, with the strongest agreement in middle and lower areas, while no notable associations existed between CT densitometric analysis and visual assessments of lung damage.
  • The findings suggest that while using PBV on DECT is possible for assessing lung perfusion in PE patients, the agreement with LPS is not very strong, indicating a need for further research.
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Article Synopsis
  • Normal aging leads to brain structure and function changes that are linked to cognitive decline, with key regions being the prefrontal cortex (PFC) and subcortical areas.
  • A study involving 422 healthy individuals used advanced imaging techniques to explore the relationship between brain structure and function, revealing that aging affects the synchronization (structure-function coupling) of various brain regions.
  • Findings suggest that increased synchronization in the PFC and thalamus is related to declines in cognitive abilities, particularly executive function and fluid intelligence, highlighting the importance of these brain areas in understanding aging and cognition.
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