4 results match your criteria: "School of Public Health and Preventive Medicine Monash University Melbourne VIC Australia.[Affiliation]"
Plasma Protein Biomarkers and Long-Term Cardiovascular Mortality Risk in Patients With Chronic Coronary Heart Disease.
J Am Heart Assoc
November 2024
Faculty Medicine and Health, NHMRC Clinical Trials Centre University of Syndey and The Royal Prince Alfred Hospital Camperdown NSW Australia.
Background: Protein biomarkers that reflect different pathophysiological pathways have been associated with the risk of adverse cardiovascular events. However, it is uncertain whether these associations are sustained with increasing years after the biomarkers are measured.
Methods And Results: In this cohort study, 7745 patients with coronary heart disease who participated in the LIPID (Long-Term Intervention With Pravastatin in Ischemic Disease) trial, BNP (B-type natriuretic peptide), troponin I, cystatin-C, C-reactive protein, d-dimer and midregional proadrenomedullin were measured at baseline and after 1 year.
Article Synopsis
- The study investigates why some older individuals (70+) remain healthy despite having high predicted risks for atherosclerotic cardiovascular disease (ASCVD), suggesting they may possess protective genetic variants.
- Researchers conducted a genome-wide association study on over 12,000 asymptomatic older adults, identifying two significant genetic variants linked to better heart health and cholesterol profiles.
- The findings, which were confirmed in a separate population, highlight the role of these genetic variants in promoting cardiovascular resilience and could point towards new therapeutic targets for preventing ASCVD.
Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features.
Clin Transl Immunology
February 2021
Department of Microbiology and Immunology University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia.
Objectives: As the world transitions into a new era of the COVID-19 pandemic in which vaccines become available, there is an increasing demand for rapid reliable serological testing to identify individuals with levels of immunity considered protective by infection or vaccination.
Methods: We used 34 SARS-CoV-2 samples to perform a rapid surrogate virus neutralisation test (sVNT), applicable to many laboratories as it circumvents the need for biosafety level-3 containment. We correlated results from the sVNT with five additional commonly used SARS-CoV-2 serology techniques: the microneutralisation test (MNT), in-house ELISAs, commercial Euroimmun- and Wantai-based ELISAs (RBD, spike and nucleoprotein; IgG, IgA and IgM), antigen-binding avidity, and high-throughput multiplex analyses to profile isotype, subclass and Fc effector binding potential.
Human γδ T-cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation.
Clin Transl Immunology
September 2019
Background: Although γδ T cells comprise up to 10% of human peripheral blood T cells, questions remain regarding their role in disease states and T-cell receptor (TCR) clonal expansions. We dissected anti-viral functions of human γδ T cells towards influenza viruses and defined influenza-reactive γδ TCRs in the context of γδ-TCRs across the human lifespan.
Methods: We performed Cr-killing assay and single-cell time-lapse live video microscopy to define mechanisms underlying γδ T-cell-mediated killing of influenza-infected targets.