Rethinking sensorimotor circuits.

New research shows that the neural circuit responsible for stabilising gaze can develop in the absence of motor neurons, contrary to a long-standing model in the field.

ATP1A3 dysfunction causes motor hyperexcitability and afterhyperpolarization loss in a dystonia model.

Mutations in the gene encoding the alpha3 Na+/K+-ATPase isoform (ATP1A3) lead to movement disorders that manifest with dystonia, a common neurological symptom with many different origins, but for which the underlying molecular mechanisms remain poorly understood. We have generated an ATP1A3 mutant mouse that displays motor impairments and a hyperexcitable motor phenotype compatible with dystonia. We show that neurons harboring this mutation are compromised in their ability to extrude raised levels of intracellular sodium, highlighting a profound deficit in neuronal sodium homeostasis.

A bidirectional association between language development and prosocial behavior in childhood: Evidence from a longitudinal birth cohort in the United Kingdom.

This study investigated a developmental cascade between prosocial and linguistic abilities in a large sample ( = 11,051) from the general youth population in the United Kingdom (50% female, 46% living in disadvantaged neighborhoods, 13% non-White). Cross-lagged panel models showed that verbal ability at age 3 predicted prosociality at age 7, which in turn predicted verbal ability at age 11. Latent growth models also showed that gains in prosociality between 3 and 5 years were associated with increased verbal ability between 5 and 11 years and vice versa.

A systematic review and meta-analysis of the relationship between sensory processing differences and internalising/externalising problems in autism.

There is evidence to suggest that sensory processing differences (SPDs) to external stimuli are a plausible underlying mechanism for mental health problems among autistic people. In the current systematic review, we examined the associations between, on the one hand, eleven types of SPDs and, on the other hand, internalising and externalising problems. The literature search was conducted on five databases (MEDLINE, PsycINFO, Web of Science, EMBASE, and CINAHL) between 1990 and August 2024.

Theories of Arousal Predict a Link Between Heart Rate Variability and Reactive Aggression: Meta-Analytic Results Disagree.

Polyvagal theory posits that habitually aggressive individuals might have an impaired capacity to calm after arousal, which has led to the investigation of Arousal-based biological indicators - "biomarkers" - of aggression, to identify individuals at high risk. The most popular approach in research examining (specifically reactive) aggression is the use of wearable technologies that can non-invasively measure heart rate variability (HRV), a cardiovascular phenomenon impacted by activation of the parasympathetic ("rest and digest") nervous system. But there is a problem: no one has systematically analyzed the results of these studies to determine if HRV is an effective predictor of reactive aggression.

Thriving… or Just Surviving? Autistic Journeys in Higher Education.

Purpose Of Review: Here we synthesise key recent (2021-2024) research that aims to understand the experience of autistic people, both staff and students, who navigate the Higher Education (HE) environment.

Recent Findings: Autistic students and staff continue to experience a lack of flexible, consistent and personalised support within the HE context, and tensions remain between the benefits of disclosure and the discrimination that may result. Significant missed opportunities remain for greater social, emotional and practical supports for autistic members of the HE community.

Neural empathy mechanisms are shared for physical and social pain, and increase from adolescence to older adulthood.

Empathy is a critical component of social interaction that enables individuals to understand and share the emotions of others. We report a preregistered experiment in which 240 participants, including adolescents, young adults, and older adults, viewed images depicting hands and feet in physically or socially painful situations (versus nonpainful). Empathy was measured using imagined pain ratings and EEG mu suppression.

The promises and challenges of neurotechnology to improve human health and cognition.

This PLOS Biology collection explores the present and possible futures of neurotechnology to improve human health and cognition, as well as the scientific, technological and ethical challenges they face.

Infants Produce Optimally Informative Points to Satisfy the Epistemic Needs of Their Communicative Partner.

Pragmatic theories assume that during communicative exchanges humans strive to be optimally informative and spontaneously adjust their communicative signals to satisfy their addressee's inferred epistemic needs. For instance, when necessary, adults flexibly and appropriately modify their communicative gestures to provide their partner the relevant information she lacks about the situation. To investigate this ability in infants, we designed a cooperative task in which 18-month-olds were asked to point at the target object they wanted to receive.

Border-ownership tuning determines the connectivity between V4 and V1 in the macaque visual system.

Cortical feedback connections are extremely numerous but the logic of connectivity between higher and lower areas remains poorly understood. Feedback from higher visual areas to primary visual cortex (V1) has been shown to enhance responses on perceptual figures compared to backgrounds, an effect known as figure-background modulation (FBM). A likely source of this feedback are border-ownership (BO) selective cells in mid-tier visual areas (e.

Vocal consensus building for collective departures in wild western gorillas.

The ability to coordinate actions is of vital importance for group-living animals, particularly in relation to travel. Groups can only remain cohesive if members possess a cooperative mechanism to overcome differences in individual priorities and social power when coordinating departures. To better understand how hominids achieve spatio-temporally coordinated group movements, we investigated vocally initiated group departures in three habituated groups of western gorillas () in the Central African Republic.

Confidence control for efficient behaviour in dynamic environments.

Signatures of confidence emerge during decision-making, implying confidence may be of functional importance to decision processes themselves. We formulate an extension of sequential sampling models of decision-making in which confidence is used online to actively moderate the quality and quantity of evidence accumulated for decisions. The benefit of this model is that it can respond to dynamic changes in sensory evidence quality.

Decoding sound content in the early visual cortex of aphantasic participants.

Listening to natural auditory scenes leads to distinct neuronal activity patterns in the early visual cortex (EVC) of blindfolded sighted and congenitally blind participants. This pattern of sound decoding is organized by eccentricity, with the accuracy of auditory information increasing from foveal to far peripheral retinotopic regions in the EVC (V1, V2, and V3). This functional organization by eccentricity is predicted by primate anatomical connectivity, where cortical feedback projections from auditory and other non-visual areas preferentially target the periphery of early visual areas.

Measuring empathic stress - A systematic review of methodology and practical considerations for future research.

Aside from stressors that each of us experience directly, we also share the stress of the people around us. Such empathic stress exists on psychological and physiological levels, including subjective, sympathetic, parasympathetic and endocrine activation. The objective of this review is to offer an overview of methodology over the past fifteen years of empathic stress research and derive practical considerations for future research endeavors in the field.

Oscillatory Brain Activity in the Canonical Alpha-Band Conceals Distinct Mechanisms in Attention.

Brain oscillations in the alpha-band (8-14 Hz) have been linked to specific processes in attention and perception. In particular, decreases in posterior alpha-amplitude are thought to reflect activation of perceptually relevant brain areas for target engagement, while alpha-amplitude increases have been associated with inhibition for distractor suppression. Traditionally, these alpha-changes have been viewed as two facets of the same process.

A post-Brexit intergroup contact intervention reduces affective polarization between Leavers and Remainers short-term.

With mounting evidence of the harmful societal consequences of affective polarization, it is crucial to find ways of addressing it. Employing a randomized controlled trial, this study tested the effectiveness of an intervention based on theories of intergroup contact and interpersonal communication in reducing affective polarization in the context of Brexit. Participants were 120 UK self-identified Leavers and Remainers.

Mourning and orienting to the future in a liminal occasion: (Re)defining British national identity after Queen Elizabeth II's death.

In this paper, we conceptualize the days of mourning that followed the passing of Queen Elizabeth II. as constituting a liminal occasion, a moment of in-betweenness through which we can explore sense-making in times of transition. How do people navigate through liminal occasions, and are they always transformative? Through a rapid response ethnography (N = 64, N = 122), we were able to capture the raw moments within which a collective comes together, as part of a national ritual, to transition from 'here' to 'there'.

Effectiveness of the 'SELF-program' on nurses' activity encouragement behavior and nursing home resident's ADL self-reliance; a cluster-randomized trial.

Background: Nurses play a crucial role in encouraging nursing home resident's activity and independent functioning. However, nurses often take over tasks unnecessarily, which can deprive resident's remaining abilities. The Function-Focused Care philosophy offers guidance for developing programs that support nurses to optimize activity and independence of older people.

Pronouns reactivate conceptual representations in human hippocampal neurons.

During discourse comprehension, every new word adds to an evolving representation of meaning that accumulates over consecutive sentences and constrains the next words. To minimize repetition and utterance length, languages use pronouns, like the word "she," to refer to nouns and phrases that were previously introduced. It has been suggested that language comprehension requires that pronouns activate the same neuronal representations as the nouns themselves.

Meta-learning in active inference.

Binz et al. propose meta-learning as a promising avenue for modelling human cognition. They provide an in-depth reflection on the advantages of meta-learning over other computational models of cognition, including a sound discussion on how their proposal can accommodate neuroscientific insights.

Measuring episodic memory and mental time travel: crossing the species gap.

Mental time travel is the projection of the mind into the past or future, and relates to experiential aspects of episodic memory, and episodic future thinking. Framing episodic memory and future thinking in this way causes a challenge when studying memory in animals, where demonstration of this mental projection is prevented by the absence of language. However, there is good evidence that non-human animals pass tests of episodic memory that are based on behavioural criteria, meaning a better understanding needs to be had of the relationship between episodic memory and mental time travel.