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Soluble costimulatory molecule sTim3 regulates the differentiation of Th1 and Th2 in patients with unexplained recurrent spontaneous abortion.

Int J Clin Exp Med

August 2015

Reproductive Medicine Center, First Affiliated Hospital of Xinjiang Medical University Urumqi 830011, Xinjiang, P. R. China ; Department of Immunology, School of Preclinical Medicine of Xinjiang Medical University Urumqi 830011, Xinjiang, P. R. China.

This study is to investigate the mechanism of unexplained recurrent spontaneous abortion (URSA). A total of 35 cases of URSA patients (URSA group), 20 cases with normal pregnancy (normal pregnancy group) and 20 healthy non-pregnancy candidates (healthy control group) were enrolled in this study. Enzyme linked immunosorbent assay (ELISA) method was used for detection of serum soluble Tim-3 (sTim3) and Galectin-9.

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