Developmental Changes in Gap Junction Expression in Rat Adrenal Medullary Chromaffin Cells.

Cell-to-cell communications are desirable for efficient functioning in endocrine cells. Gap junctions and paracrine factors are major mechanisms by which neighboring endocrine cells communicate with each other. The current experiment was undertaken to morphologically examine gap junction expression and developmental changes in rat adrenal medullary chromaffin (AMC) cells.

Enhancing emotion expression (3E): A novel virtual reality tool for improving alexithymia and its psychological outcomes from a multi-dimensional perspective.

Background: Alexithymia is characterized by an impaired ability in emotion awareness, expression, and regulation, associated with deficits in social and mental functioning. This study aims to develop a tool for addressing alexithymia and its psychological outcomes.

Method: In this paper, 102 subjects were recruited to investigate the relationship between alexithymia and psychological outcomes, along with the mediating role of emotion awareness, expression, and regulation.

Daily activities and suspected dementia among community-dwelling older adults: a cross-sectional study.

Background: Dementia is undiagnosed among many older adults, and more than half the people in local communities live with symptoms of dementia are not properly treated.

Objective: The study aims to explore the relationship between decline of daily activities and the incidence of suspected dementia.

Methods: A two-stage sampling method was used to conduct a multicenter cross-sectional survey.

Mediating and moderating factors between stigma and adaptability to return to work for cancer survivors.

Adaptability to return to work is a process by which cancer survivors(CSs) utilize accessible resources to reconstruct themselves. While the stigma, financial situation and social support are known to influence their adaptability to return to work, the mechanisms by which these factors work remain unclear. This study proposes a moderated mediation model to signify a pathway linking stigma to the adaptability to return to work.

Evaluating optimal rehabilitation strategies in ICU: study protocol for a multicentre cohort study to assess Physical Activity dosing, Muscle mass, and physICal outcomeS (IPAMICS study).

Background: Many patients who get discharged from the intensive care unit experience physical dysfunction that persists even after discharge. Physical dysfunction is associated with skeletal muscle atrophy and accompanying intensive care unit-acquired weakness in the early stages of intensive care unit admission, and early diagnosis and prevention with early mobilization are crucial. However, the amount of physical activity required for early mobilization remains controversial in critically ill patients.

The mediating role of resilience and sleep quality between self-efficacy and prenatal anxiety: A mediational analysis.

Background And Objective: During pregnancy, prenatal anxiety is one of the most common mental disorders that women experience. This study aims to assess the prevalence of prenatal anxiety among Chinese pregnant women and explore the parallel mediating role of resilience and sleep quality in the relationship between self-efficacy and prenatal anxiety.

Methods: Between February and June 2023, a total of 1071 pregnant women were recruited from three hospitals in Nantong, Jiangsu Province, China, using a convenience sampling method.

Adverse childhood experiences and 10-year depressive-symptoms trajectories among middle-aged and older adults in China: a population-based cohort study.

Background: Adverse childhood experiences (ACEs) influence depressive symptoms. Depressive symptoms were heterogeneous from the perspective of life course.

Objective: To explore the effects of ACEs on the trajectory of depressive symptoms in China.

Psychometric properties of the modified Chinese version of the family resilience assessment for families of patients with cancer.

Family resilience is critical for families recovering and growing from a cancer crisis; however, there remains a lack of universal family resilience assessment tools for families of patients with cancer. This study aimed to modify the Family Resilience Assessment Scale (FRA) and examine its psychometric properties. First, the FRA scale was modified into the Family Resilience Assessment Scale for Family Cancer (FRAS-FC) based on cultural adaptations and cancer population applicability.

CircMETTL9 targets CCAR2 to induce neuronal oxidative stress and apoptosis via mitochondria-mediated pathways following traumatic brain injury.

Traumatic brain injury (TBI) remains a principal factor in neurological disorders, often resulting in significant morbidity due to secondary neuroinflammatory and oxidative stress responses. While circular RNAs are recognized for their high expression levels in the nervous system and play crucial roles in various neurological processes, their specific contributions to the pathophysiology of TBI remain underexplored. In this study, the possible molecular mechanisms through which circMETTL9 modulated oxidative stress and neurological outcomes following TBI were investigated.

Synergistic effects of combined lead and iprodione exposure on P53 signaling-mediated hepatotoxicity, enterotoxicity and transgenerational toxicity in zebrafish.

Environmental heavy metal contamination, combined with inappropriate use of fungicides, has led to the co-existence of lead (Pb) and iprodione (IPR), presenting signification risks to ecosystems and human health. The toxic effects resulting from concurrent exposure to Pb and IPR, however, remain poorly understood. In the study, we conducted a comprehensive 60-day subchronic study to investigate the toxic effects on the liver and gut in parental male zebrafish through employing multi-omics analyses.

Status quo and influencing factors of posttraumatic growth of nurses exposed to nurse-to-nurse horizontal violence: a cross-sectional multicenter study.

Background: Post-Traumatic Growth (PTG) relieves physical and psychological stress symptoms in nurses who exposed to nurse-to-nurse horizontal violence (HV), has great intervention potential to reverse the negative effects of HV events. Therefore, in-depth exploration of the overall characteristics of PTG in HV-exposed nurses and its influencing factors are of great practical significance to provide them with precise psychological adaptive interventions.

Objective: This study aims to describe the current state of PTG of HV-exposed nurses and its influencing factors.

The impact of social frailty on mortality in older patients with chronic heart failure: A prospective cohort study.

Background: There is still insufficient longitudinal evidence regarding the risk of mortality in older patients with chronic heart failure (CHF) and social frailty (SF).

Objectives: The purpose of study was to describe the incidence rate of non-SF, pre-SF, and SF in older patients with CHF and explore its impact on mortality.

Methods: The observational study was conducted at a tertiary hospital in China.

Development of a growth mindset assessment scale for nursing students based on the growth mindset model: A mixed-method study.

Objective: The aim was to develop a growth mindset assessment scale based on the growth mindset model.

Background: Growth mindset is a critical factor in the development of nursing students, but there are limited tools available to measure growth mindset effectively among nursing students.

Design: A Delphi study and cross-sectional study.

Factors related to the treatment burden of patients with coronary heart disease: A cross-sectional study.

Background: Treatment burden is a significant barrier to patient adherence that may lead to deterioration of health.

Objectives: The purpose of this study was to understand the treatment burden of Chinese patients with coronary heart disease (CHD) and its associations with demographic, capacity, and workload-related factors.

Methods: We conducted an observational cross-sectional study.

Intraventricular Medication with or without Ventricular Shunt for Leptomeningeal Metastases with Different Intracranial Pressure: A Single-Center, Large-Scale Retrospective Study.

Objective: To evaluate the efficacy and prognosis of intraventricular medication (IVM) administered via the reservoir of Ommaya or ventricular shunt (VS) system to control leptomeningeal metastases, with or without VS based on intracranial pressure, in combination with postoperative systemic therapy.

Methods: Between April 2021 and December 2022, 125 patients with leptomeningeal metastases were managed in our department who underwent Ommaya reservoir placement and/or VS and subsequently received IVM postoperatively. The extent of symptom amelioration and survival, as well as the determinants influencing prognosis, were evaluated.

Case Report: Sudden death caused by methylene chloride poisoning.

Dichloromethane is widely used as an organic solvent in aerospace, electronics, and medicine. Cases of poisoning caused by this substance are rare. Recently, we successfully treated a patient with an acute dichloromethane poisoning.

The Psychometric Properties of the Chinese Version of the Pain Relief Motivation Scale in Patients With Neurogenic Chronic Pain.

Background: The Pain Relief Motivation Scale (PRMS) was administered to chronic pain sufferers and predicts their psychological well-being. However, the Chinese version of the PRMS has not undergone psychometric validation.

Objectives: The PRMS will be psychometrically validated in patients with neuropathic pain-induced chronic pain from mainland China.

Fluoxetine treatment reverses chronic stress-induced promotion on Fk506-binding protein 5 expression and multiple effects on glucocorticoid receptor phosphorylation in the paraventricular nucleus of mice.

Background: Fluoxetine is widely used as a first-line antidepressant. However, the molecular mechanisms for its antidepressant effects are still not fully understood. Hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis is a core pathogenic mechanism contributing to depression, and fluoxetine treatment prevents this dysfunction.

The effect and mechanism of IL-37d on neutrophil recruitment in the early stage of tumor metastasis in the lungs.

Background: Chronic inflammation plays a pivotal role in cancer progression, with tumor-associated neutrophils (TANs) actively shaping the pre-metastatic niche. Interleukin-37 (IL-37), a known immunosuppressive cytokine, is implicated in this regulation, although its precise function remains underexplored.Therefore, this study seeks to further elucidate the inhibitory effect of IL-37d on neutrophil recruitment within the pre-metastatic lung microenvironment and its underlying mechanisms, thereby providing a theoretical foundation for clinical interventions in the early stages of cancer progression.

Correlations of strength, proprioception, and dynamic balance to the Cumberland Ankle Instability Tool Score among patients with chronic ankle instability: a cross-sectional study.

Background: The Cumberland Ankle Instability Tool (CAIT) is used to screen patients with chronic ankle instability (CAI) and to quantify the severity of ankle instability. Neuromuscular deficits are common in CAI, including proprioception, strength, and balance issues. The relationship between CAIT scores and neuromuscular factors is unclear.

The role of empathy and emotional regulation self-efficacy in adult attachment type and marital adjustment in breast cancer patients-a moderated mediation model.

To date, previous research has elucidated the impact of adult attachment type on marital relationships. However, the mechanisms underpinning the relationship between attachment type and marital adjustment in breast cancer patients remain unclear. In this study, a cohort of 272 breast cancer patients was surveyed using several instruments: the General Information Questionnaire, Revised Marital Adjustment Scale (RDAS), Adult Attachment Scale (AAS), Interpersonal Reactivity Indicator Scale (IRI), and Regulated Emotional Self-Efficacy Scale (RESS).

[Screen exposure status and related factors in children with epilepsy].

Objectives: To understand the status of screen exposure in children with epilepsy and analyze the influencing factors for screen exposure time, providing a scientific basis for managing screen exposure in these children.

Methods: A convenience sampling method was used to select 275 children with epilepsy from outpatient clinics or those undergoing 24-hour electroencephalogram monitoring at two tertiary hospitals in Jinan from March to June 2023. Their parents (fathers or mothers) completed a questionnaire to collect data on screen exposure, parental screen regulation behaviors, and related information about the children and their families.