Cyclical Stretching Induces Excess Intracellular Ca2+ Influx in Human Keloid-Derived Fibroblasts In Vitro.

Background: The incidence of keloids is higher in the case of darker skin. It is more common in the parts exposed to stretching (thorax, abdomen, and joints). Cyclical stretching reportedly induced each Ca2+ spike through differential mechanosensitive channels in human synovial and dermal fibroblasts.

Piflufolastat F-18 (F-DCFPyL) for PSMA PET imaging in prostate cancer .

Introduction: Accurate imaging is essential for staging prostate cancer and guiding management decisions. Conventional imaging modalities are hampered by a limited sensitivity for metastatic disease. Nearly all prostate cancers express prostate-specific membrane antigen (PSMA) and F-DCFPyL (piflufolastat F 18) is a new FDA-approved positron emission tomography (PET) agent that targets PSMA for improved staging of prostate cancer.

Sympathetic Ophthalmia - An Overview.

Introduction: Sympathetic ophthalmia (SO) is rare, bilateral granulomatous panuveitis that typically occurs following penetrating or perforating ocular trauma or surgery. This review aims to provide an update on the etiopathogenesis, clinical presentations, diagnosis and treatment of SO.

Methods: Reports cited in MEDLINE database, that analyzed SO in at least 5 patients, published prior to December 1st, 2021 were included.

Transcriptional Analysis of Liver Tissue Identifies Distinct Phenotypes of Indeterminate Pediatric Acute Liver Failure.

Many patients with indeterminate pediatric acute liver failure (PALF) have evidence of T-cell driven immune injury; however, the precise inflammatory pathways are not well defined. We have characterized the hepatic cytokine and transcriptional signatures of patients with PALF. A retrospective review was performed on 22 children presenting with indeterminate (IND-PALF; n = 17) or other known diagnoses (DX-PALF; n = 6) with available archived liver tissue.

Reaction Time Predicts Brain-Computer Interface Aptitude.

There is evidence that 15-30% of the general population cannot effectively operate brain-computer interfaces (BCIs). Thus the BCI performance predictors are critically required to pre-screen participants. Current neurophysiological and psychological tests either require complicated equipment or suffer from subjectivity.

A structured framework for optimizing surgical quality through process-of-care trials.

Increased national focus has been placed on care delivery processes and their effect on health care quality. At the institutional level, investigators are increasingly engaged in surgical process-of-care trials that, compared to traditional randomized treatment trials, more explicitly control and mitigate provider- and system-based risk. Process-of-care trials have the potential to improve patient care while also improving the culture of a surgical department, hospital, and system.

Chemokine (C-C motif) receptor 7 (CCR7) associates with the tumour immune microenvironment but not progression in invasive breast carcinoma.

Some previous studies have reported that the chemokine (C-C motif) receptor 7 (CCR7) plays a role in breast cancer, is associated with lymph node metastasis and drives the site of distant metastasis. However, the impact of its expression on patient outcome and its association with tumour infiltrating inflammatory cells remain to be validated. We evaluated CCR7 protein expression by immunohistochemistry in a large well characterized cohort ( = 866) of early invasive primary breast cancers.

The Utility of Cloud Computing in Analyzing GPU-Accelerated Deformable Image Registration of CT and CBCT Images in Head and Neck Cancer Radiation Therapy.

The images generated during radiation oncology treatments provide a valuable resource to conduct analysis for personalized therapy, outcomes prediction, and treatment margin optimization. Deformable image registration (DIR) is an essential tool in analyzing these images. We are enhancing and examining DIR with the contributions of this paper: 1) implementing and investigating a cloud and graphic processing unit (GPU) accelerated DIR solution and 2) assessing the accuracy and flexibility of that solution on planning computed tomography (CT) with cone-beam CT (CBCT).

Delayed Facial Palsy After Microvascular Decompression for Hemifacial Spasm.

The purpose of this article is to study the etiology, treatment, and prognosis of delayed facial palsy (DFP) after microvascular decompression (MVD) for the hemifacial spasm. Between January 2012 and January 2014, 562 patients who underwent MVD for hemifacial spasm at our institution were retrospectively studied. Among 562 patients, 34 patients developed DFP after MVD with an incidence of 6%.

The anti-apoptosis effect of MLAA-34 in leukemia and the β-catenin/T cell factor 4 protein pathway.

Objective This study aims to observe the effects of MLAA-34 gene in leukemia and explore its mechanism. Methods MLAA-34 RNAi vector was constructed. NOD/SCID mice and 293T cells, K562 cells, HL60 cells and U937 cells were used in this study.