2,349 results match your criteria: "School of Medicine at Temple University[Affiliation]"
Dissecting cellulitis mimicking kerion in a 9-year-old boy.
JAAD Case Rep
December 2024
Department of Dermatology, University of Connecticut School of Medicine, Farmington, Connecticut.
Compensatory adaptation of parallel motor pathways promotes skilled forelimb recovery after spinal cord injury.
iScience
December 2024
Department of Neuroscience, Shriners Hospitals Pediatric Research Center, Center for Neural Rehabilitation and Repair, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Skilled forelimb patterning is regulated by the corticospinal tract (CST) with support from brainstem regions. When the CST is lesioned, there is a loss of forelimb function; however, if indirect pathways remain intact, rehabilitative training can facilitate recovery. Following spinal cord injury, rehabilitation is thought to enhance the reorganization and plasticity of spared supraspinal-propriospinal circuits, aiding functional recovery.
View Article and Find Full Text PDFHigh intracranial pressure following endoscopic third ventriculostomy: illustrative case.
J Neurosurg Case Lessons
December 2024
Department of Neurosurgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Background: Endoscopic third ventriculostomy (ETV) is an effective procedure for the treatment of triventriculomegaly associated with aqueductal stenosis. However, some patients can develop severe and symptomatic intracranial pressure (ICP) elevations in the immediate postoperative period that can be monitored and treated with external ventricular drain (EVD) placement and controlled cerebrospinal fluid (CSF) diversion until the ICP normalizes and symptoms resolve.
Observations: The authors describe the case of a 39-year-old male who underwent ETV and intraoperative EVD placement for obstructive hydrocephalus associated with aqueductal stenosis.
Critical Care Decisions After Large Core Cerebral Infarctions: A Secondary Analysis From the SELECT2 Trial.
Ann Neurol
April 2025
Department of Neurology and Stroke, University Hospital Cleveland Medical Center, Case Western Reserve University, Cleveland, OH.
Article Synopsis
- This study analyzed decisions regarding decompressive hemicraniectomy (DHC) and early withdrawal of life-sustaining therapy (WLST) in patients with large vessel occlusion (LVO) and large ischemic strokes from the SELECT2 trial.* -
- Among 352 patients, DHC was utilized in 55 patients, and WLST was chosen for 81, showing no significant differences in usage between those receiving endovascular thrombectomy (EVT) and those treated medically.* -
- About 21% of DHC patients were able to walk independently after one year, indicating that DHC did not negatively impact the benefits of thrombectomy, while WLST generally resulted in poor outcomes.*
GOLD Science Committee recommendations for the use of pre- and post-bronchodilator spirometry for the diagnosis of COPD.
Eur Respir J
February 2025
University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK.
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) report states that the diagnosis of COPD should be considered in individuals with chronic respiratory symptoms and/or exposure to risk factors. Forced spirometry demonstrating airflow obstruction after bronchodilation is required to confirm the diagnosis using a threshold of forced expiratory volume in 1 s (FEV)/forced vital capacity (FVC) ratio <0.7.
View Article and Find Full Text PDFA quantitative method for assessing treatment-related changes within the airway mucosa in patients with chronic bronchitis.
Respir Med
January 2025
Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, 3500 North Broad Street, Philadelphia, PA, 19140, USA. Electronic address:
Background: No standardized method has yet been established for evaluating airway mucosal aberrancies associated with chronic obstructive pulmonary disease (COPD) or chronic bronchitis (CB). While goblet cell hyperplasia (GCH) is an established pathognomonic hallmark of the CB disease process, no standardized method exists for acquiring mucosal biopsies and assessing morphologic airway mucosa alterations. Additionally, the impacts from interventions targeting the airway mucosa are not well defined.
View Article and Find Full Text PDFRecent advances in discovery and functional analysis of the small proteins and microRNA expressed by polyomaviruses.
Virology
January 2025
Lewis Katz School of Medicine at Temple University, Department of Microbiology, Immunology and Inflammation Center for Neurovirology and Gene Editing, 3500 N. Broad Street, Philadelphia, PA, 19140, USA. Electronic address:
Article Synopsis
- * Some polyomaviruses can cause serious diseases such as polyomavirus-associated nephropathy, progressive multifocal leukoencephalopathy, trichodysplasia spinulosa, and Merkel cell carcinoma.
- * Recent research focuses on the functions of viral proteins and microRNA that these viruses express, shedding light on their role in viral biology, how they transform cells, and their potential impact on disease progression.
Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia.
Sci Adv
November 2024
Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA.
Article Synopsis
- Research shows that the endocannabinoid (eCB) system could be a target for new treatments to complement opioid therapies.
- Enhancing levels of 2-arachidonoylglycerol (2-AG) through a specific enzyme inhibitor in mice reduces the rewarding effects of opioids without affecting their pain-relieving abilities.
- The research indicates that these effects are linked to cannabinoid receptor 1 (CB1R) in a certain brain area, suggesting that boosting 2-AG could help in treating opioid addiction while maintaining pain management.
Concerns Regarding the Utility of High-Risk Pancreatic Cancer Surveillance.
JAMA Oncol
January 2025
Department of Epidemiology and Biostatistics, University of California, San Francisco.
The Management of Interstitial Lung Disease in the ICU: A Comprehensive Review.
J Clin Med
November 2024
Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Article Synopsis
- Interstitial lung disease (ILD) includes a variety of lung diseases marked by inflammation and fibrosis, often leading patients to require hospitalization and possibly ICU care due to respiratory failure.
- Diagnosis of ILD relies heavily on chest CT scans, while acute exacerbations necessitate thorough evaluation for triggers and possible infections, with treatments like corticosteroids, oxygen therapy, and careful ventilation strategies.
- Advanced treatments like lung transplantation may be considered for those with end-stage ILD, but the decision hinges on the patient's condition and urgency of the situation.
Variation of Stomach Shapes in Gastric Emptying Scintigraphy: Correlation With Gastric Emptying Results, Body Weight, and Symptoms.
Neurogastroenterol Motil
February 2025
Section of Gastroenterology, Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Article Synopsis
- This study aimed to explore how different stomach shapes observed in gastric emptying scintigraphy (GES) relate to gastric emptying speeds, body weight, and GI symptoms.
- Researchers reviewed 397 GES studies, identifying five stomach shapes: crescentic, J-shaped, reversed-L, cylindrical, and bag-like, with crescentic being the most common.
- Findings revealed that crescentic stomachs had the highest body mass index (BMI), while bag-like stomachs showed the slowest gastric emptying and more severe regurgitation and heartburn symptoms.
JC virus small tumor antigen promotes S phase entry and cell cycle progression.
Tumour Virus Res
December 2024
Lewis Katz School of Medicine at Temple University, Department of Microbiology, Immunology and Inflammation, Center for Neurovirology and Gene Editing, 3500 N. Broad Street, Philadelphia, PA, 19140, USA. Electronic address:
Article Synopsis
- - The JC virus (JCV) encodes multiple regulatory proteins, including large T antigen (LT-Ag) and small t antigen (Sm t-Ag), through alternative splicing of its pre-mRNA, with LT-Ag known for its role in cell transformation.
- - The study found that Sm t-Ag aids cell cycle progression by facilitating the transition from G0/G1 to S phase, which involves early expression of important cyclins and cyclin-dependent kinases (like cyclin B and Cdk2).
- - Sm t-Ag is shown to enhance growth-promoting pathways such as the PI3K/Akt/mTOR axis, leading to increased levels of active proteins like phosphorylated-Akt, suggesting
Phenotypes and Trajectories of Tobacco-exposed Persons with Preserved Spirometry: Insights from Lung Volumes.
Ann Am Thorac Soc
November 2024
UCSF, Division of Pulmonary and Critical Care Medicine, Department of Medicine and CVRI, San Francisco, California, United States.
Among tobacco-exposed persons with preserved spirometry (TEPS), we previously demonstrated that different lung volume indices, specifically elevated total lung capacity (TLC) versus elevated ratio of functional residual capacity-to-TLC (FRC/TLC), identify different lung disease characteristics in the COPDGene cohort. Determine differential disease characteristics and trajectories associated with the lung volume indices among TEPS in the SPIROMICS cohort. We categorized TEPS (n=814) by tertiles (low, intermediate, high) of TLC or residual volume-to-TLC (RV/TLC) derived from baseline CT images, and then examined clinical and spirometric disease trajectories in mutually exclusive categories of participants with high TLC without high RV/TLC ([TLC]) versus high RV/TLC without high TLC ([RV/TLC]).
View Article and Find Full Text PDFMitochondrial dysfunction and impaired DNA damage repair through PICT1 dysregulation in alveolar type II cells in emphysema.
Cell Commun Signal
November 2024
Center for Inflammation and Lung Research, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA, 19140, USA.
Article Synopsis
- - Alveolar type II (ATII) cells play a critical role in lung repair but their damage, often caused by cigarette smoke, contributes to the onset of emphysema, marked by destruction of alveolar walls.
- - Researchers examined ATII cells from non-smokers, smokers, and emphysema patients, focusing on the protein PICT1 and its role in disease progression, using both human cell analysis and a murine model.
- - Findings revealed decreased PICT1 levels in emphysema, linked to reduced DNA damage repair capabilities and mitochondrial dysfunction, suggesting that targeting PICT1 could lead to new treatments for the disease.
Treatment of Xylazine-Associated Injection Skin Injuries.
Case Rep Dermatol Med
November 2024
Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Article Synopsis
- The introduction of fentanyl and xylazine in the drug market has led to an increase in severe skin injuries among injection drug users, specifically from "tranq wounds."
- This case series examines four patients treated for severe xylazine-related skin injuries, highlighting the deep, ulcerative wounds caused by the drug and the complications in their healing process.
- The study emphasizes the need for a better understanding of these injuries, as treatment is often complicated by factors related to patients' social conditions and the ongoing prevalence of xylazine in the U.S. drug supply.
Guidance for clinical management of pathogenic variant carriers at elevated genetic risk for ALS/FTD.
J Neurol Neurosurg Psychiatry
January 2025
Department of Basic and Clinical Neuroscience, King's College London, London, UK.
Article Synopsis
- There is an increasing awareness of the early stages of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), leading to new efforts aimed at prevention, largely driven by the participation of individuals at genetic risk. !* -
- A recent workshop outlined recommendations for clinical care and lifestyle management tailored to those at elevated risk for ALS and FTD, covering aspects such as genetic testing, early symptom monitoring, and FDA-approved treatments. !* -
- The guidance document seeks to inform both patients and healthcare providers about best practices and highlights the need for further research to strengthen evidence for future recommendations. !*
Article Synopsis
- The ASFA Attending Physician Subcommittee reviewed 2023 apheresis literature and selected the top 10 seminal articles in the field.
- They focused on four main topics: donor apheresis, therapeutic apheresis, education, and cellular therapy, using PubMed and OVID for research.
- The chosen articles met key criteria such as novel findings, practice-changing results, and relevance to current clinical practice, while excluding case reports, reviews, and meta-analyses.
Sidney Yankauer, the Mechanical Genius.
Ear Nose Throat J
November 2024
Department of Otolaryngology-Head & Neck Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Smoking and outcomes in candidates for liver transplantation: Analysis of the Pulmonary Vascular Complications of Liver Disease 2 (PVCLD2).
Liver Transpl
November 2024
Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Patients with chronic liver disease commonly have abnormal lung function; however, the impact of smoking on outcomes in these patients is unknown. We hypothesized current or past smoking would be associated with worse survival in patients with advanced liver disease. The Pulmonary Vascular Complications in Liver Disease Study 2 (PVCLD2) was a prospective cohort of patients with advanced liver disease undergoing evaluation for liver transplantation (LT).
View Article and Find Full Text PDFAdvanced emphysema leads to high false positivity rate for pneumothorax in point of care ultrasound.
Respir Med
December 2024
Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Article Synopsis
- Point of Care Ultrasound (POCUS) is used to assess pleural movement in patients with advanced emphysema, but its effectiveness in these patients is not well established.
- A study evaluated ultrasound findings in 48 COPD patients and found a significant number showed abnormal patterns, such as absent lung sliding or a barcode appearance.
- Results indicated there is limited correlation between ultrasound abnormalities and standard lung function measures, highlighting a need for cautious interpretation of POCUS in these cases.
Facial Filler Injections: Questions Patients Ask and Where They Find Answers.
ORL J Otorhinolaryngol Relat Spec
March 2025
Department of Otorhinolaryngology - Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Article Synopsis
- Patients frequently search for information about facial fillers, with a significant focus on the costs associated with these procedures.
- A study using the Ahrefs tool revealed that websites providing filler information vary in quality, with private practice sources rated lower on the JAMA score compared to corporate sources.
- Interest in lip fillers specifically has grown more rapidly than inquiries about other types of injections over the past three years, highlighting a shift in consumer interest.
Epidemiology and Characteristics of Women With Facial Fractures Seeking Emergency Care in the United States: A Retrospective Cohort Study.
Craniomaxillofac Trauma Reconstr
May 2024
Division of Plastic and Reconstructive Surgery, Fox Chase Cancer Center, Philadelphia, PA, USA.
Article Synopsis
- Facial bone fractures are less common in women than in men in the U.S., yet there is limited knowledge about the specifics of women who experience these injuries.
- The study aims to analyze the characteristics, types, and costs of emergency care for women with facial fractures using 2019 data from the National Emergency Department Sample.
- Findings show that while women represent 37% of facial fractures in emergency settings, they tend to be older, more likely to be on Medicare, and have lower medical costs compared to men, but the total financial burden for their care is significant at $1.6 billion.
Exploring Socioeconomic Disparities in Mandibular Trauma: A Retrospective Cohort Analysis of Patient Profiles and Treatment Outcomes.
Craniomaxillofac Trauma Reconstr
December 2024
Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Article Synopsis
- - The study is a retrospective chart review focusing on mandible fractures in an urban hospital serving a low-income population, aiming to identify risk factors and reduce complications associated with these injuries.
- - From 272 patients analyzed, a significant majority of fractures (78.3%) were linked to interpersonal violence; key risk factors for complications included financial deprivation, type of fracture, tobacco use, hepatitis C history, and discharge to rehab programs.
- - The findings emphasize the importance of addressing comorbid issues like substance use and providing comprehensive support through a multidisciplinary approach to improve treatment outcomes for at-risk patients.
Incidence and Characterization of Facial Lacerations in Emergency Departments in the United States.
Craniomaxillofac Trauma Reconstr
May 2024
Division of Plastic and Reconstructive Surgery, Fox Chase Cancer Center, Philadelphia, PA, USA.
Article Synopsis
- - This study analyzes data from the Nationwide Emergency Department Sample to understand characteristics and costs associated with emergency department visits for facial lacerations from 2019.
- - Findings reveal over 2.5 million ED visits, primarily unintentional injuries, with scalps being the most common injury site, predominantly affecting adult males who often have private insurance.
- - Most encounters occurred during summer months (June-August) in large urban areas and at teaching hospitals, highlighting the demographic and economic factors involved in facial laceration treatment in the U.S. emergency departments.
Comparison of outcomes between single-port and multi-port robotic radical nephrectomy.
J Robot Surg
November 2024
Department of Urology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, 6th Floor, New York City, NY, 10029, USA.
Article Synopsis
- Single-port (SP) robotic surgery is being compared to multi-port (MP) surgery to assess their effectiveness in robotic radical nephrectomy (RN), focusing on various outcomes like surgery time and recovery.* -
- In a study of 341 patients, the SP group (14% of the total) had smaller tumors and longer operative times compared to the MP group but similar overall safety and recovery metrics.* -
- SP robotic surgery may lead to shorter hospital stays and smaller incisions, despite longer surgery times, illustrating its potential benefits while maintaining safety comparable to MP methods.*