552 results match your criteria: "School of Medicine and Population[Affiliation]"
Lancet HIV
January 2025
Division of Infectious Diseases, Washington University School of Medicine, St Louis, MO, USA.
Background: Recipients of health services value not only convenience but also respectful, kind, and helpful providers. To date, research to improve person-centred HIV treatment has focused on making services easier to access (eg, differentiated service delivery) rather than the interpersonal experience of care. We developed and evaluated a person-centred care (PCC) intervention targeting practices of health-care workers.
View Article and Find Full Text PDFJ Infect
January 2025
Department of Infectious Diseases and Tropical medicine, Sheffield Teaching Hospitals, Sheffield, United Kingdom; School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom. Electronic address:
J Immunol Methods
January 2025
GSK Vaccines Institute for Global Health (GVGH), GSK Global Health Vaccines R&D, Via Fiorentina 1, 53100 Siena, Italy. Electronic address:
Exposure to Group A Streptococcus leads to a broad spectrum of disease and sequelae, as the bacterium employs a wide range of virulence factors to facilitate colonization of the host, propagation and onward transmission, disrupting both innate and adaptive immune responses. The protease SpyCEP has a crucial role in contributing to bacterial immune evasion by impairing neutrophil recruitment and killing of bacteria through the cleavage of interleukin-8 (IL-8). Given this critical function, SpyCEP represents a key vaccine antigen and quantifying functional anti-SpyCEP antibodies represents not only an important marker of vaccine efficacy, but also a tool to dissect the natural immune response.
View Article and Find Full Text PDFTrials
December 2024
School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
Background: The acceptability of a children's premedication, prior to general anaesthesia (GA), is fundamental to ensuring positive clinical- and patient-reported outcomes. Midazolam, the current standard premedication, is known to have an unfavourable side-effects profile and presents a degree of risk which is accepted due to a need for compliance. Melatonin is a functionally diverse hormone with anxiolytic properties that offer potential benefits over midazolam.
View Article and Find Full Text PDFLife Sci Alliance
February 2025
Sheffield Institute for Translational Neuroscience (SITraN), Division of Neuroscience, School of Medicine and Population Health, Faculty of Health, University of Sheffield, Sheffield, UK
A G4C2 hexanucleotide repeat expansion in is the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD). Bidirectional transcription and subsequent repeat-associated non-AUG (RAN) translation of sense and antisense transcripts leads to the formation of five dipeptide repeat (DPR) proteins. These DPRs are toxic in a wide range of cell and animal models.
View Article and Find Full Text PDFPharmacoeconomics
December 2024
Sheffield Centre for Health and Related Research, School of Medicine and Population Health, University of Sheffield, Sheffield, S1 4DA, England.
Background: Guidelines for modelling in economic evaluation recommend that it may be necessary to consider costs and outcomes until all modelled patients have died. Some guidelines also recommend that carers' health-related quality of life (HRQoL) outcomes should be included. However, it is unclear whether economic evaluations should continue to include carers' HRQoL after patients have died, and whether there is any evidence to support an additional bereavement effect for carers.
View Article and Find Full Text PDFQual Life Res
November 2024
School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Purpose: Evidence of comprehensibility is frequently required during the development of patient reported outcome measures (PROMs); the respondent's interpretation of PROM items needs to align with intended meanings. Cognitive interviews are recommended for investigating PROM comprehensibility, yet guidance for analysis is lacking. Consequently, the quality and trustworthiness of cognitive interview data and analysis is threatened, as there is no clear procedure detailing how analysts can systematically, and consistently, identify evidence that respondent interpretations align/misalign with intended meanings.
View Article and Find Full Text PDFSci Rep
December 2024
Biochemical Pharmacology,William Harvey Research Institute, Barts & The London Faculty of Medicine &Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Local haemodynamics control arterial homeostasis and dysfunction by generating wall shear stress (WSS) which regulates endothelial cell (EC) physiology. Here we use a zebrafish model to identify genes that regulate EC proliferation in response to flow. Suppression of blood flow in zebrafish embryos (by targeting cardiac troponin) reduced EC proliferation in the intersegmental vessels (ISVs) compared to controls exposed to flow.
View Article and Find Full Text PDFAddiction
December 2024
Department of Psychology, University of Sheffield, UK.
Background And Aims: Buying smaller-sized alcohol products can reduce alcohol consumption, but larger products have better value for money, which presents a barrier to switching. We tested whether proportional pricing prompts drinkers to buy smaller alcohol products and reduce alcohol purchasing.
Design, Setting And Participants: This study was an online experiment set in the United Kingdom, using hypothetical shopping tasks in which participants purchased different-sized products presented under proportional pricing (i.
Front Plant Sci
November 2024
Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Tartu, Estonia.
World J Gastrointest Pathophysiol
November 2024
Department of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield S10 2JF, United Kingdom.
This comprehensive review addresses the global health challenge of disparities in pancreas transplant access, particularly in low- and middle-income countries (LMICs) compared to high-income countries. Despite advancements in surgical techniques and immunosuppression for procedures like simultaneous pancreas-kidney, pancreas-after-kidney, and pancreas-transplant alone, LMICs face significant challenges, including limited infrastructure, financial constraints, and a shortage of skilled medical professionals. Donation after brain death remains constrained by sociocultural barriers.
View Article and Find Full Text PDFMed Teach
December 2024
School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Purpose Of The Article: Generative AI can potentially streamline the creation of practice exam questions. This study sought to evaluate medical students' confidence using generative AI for this purpose, and overall attitudes towards its use.
Materials And Methods: The study used a mixed-methods approach with a pre-post intervention design.
Soc Sci Med
January 2025
Department of Behavioural Science and Health, University College London, UK; SPECTRUM Consortium, UK.
Background: Great Britain has been experiencing a cost-of-living crisis since late 2021, with the cost of everyday essentials rising more quickly than the average household income. This study provides up-to-date information on levels of subjective and objective financial hardship during this crisis, differences across population subgroups, and associations with psychological distress.
Methods: We used data from a representative cross-sectional survey of adults (≥16 y) in Great Britain (n = 7,027) conducted January-March 2023.
Int J Surg Case Rep
January 2025
Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
Introduction: Solid pseudopapillary neoplasm (SPN) is an extremely rare, low-grade, malignant pancreatic tumour with an excellent prognosis. We describe a case of SPN causing obstructive jaundice in a young female, thus mimicking pancreatic adenocarcinoma clinically and radiologically.
Case Presentation: A 32-year-old female presented with abdominal pain for 12 h, icterus, and an epigastric mass measuring 3 × 3 cm.
Radiol Cardiothorac Imaging
December 2024
From the Department of Radiology, University of Washington, Seattle, Wash (D.M.); Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (S.G.); Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom (S.A.); INSIGNEO, Institute for In Silico Medicine, University of Sheffield, Sheffield, United Kingdom (S.A.); NIHR Sheffield Biomedical Research Centre, Sheffield, United Kingdom (S.A.); Department of Medical Imaging, University of Toronto, Toronto, Canada (K.H.); University Medical Imaging Toronto, Joint Department of Medical Imaging, University Health Network, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5S 1A1 (K.H.); and Department of Cardiovascular Sciences, NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Leicester, United Kingdom (G.S.G.).
Ther Adv Gastrointest Endosc
November 2024
Academic Unit of Gastroenterology, Sheffield Teaching Hospitals, Sheffield, UK.
Background: The faecal immunochemical test (FIT) is an immunoassay used to detect human blood in the stool. The role of FIT as a screening tool for small bowel pathology remains unclear.
Objectives: This study aimed to investigate the role of FIT in predicting small bowel pathology in patients with iron deficiency anaemia (IDA).
J Diabetes Metab Disord
December 2024
Orthopaedic Department, Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Trust, 54124OX3 7LD Oxford, UK.
Objectives: Impaired awareness of hyperglycaemia (IAH) affects approximately 20-40% of people living with type 1 diabetes (T1D), predisposing them to severe hypoglycaemia. This systematic review evaluated the efficacy of closed-loop automated insulin delivery systems (CL-AID) in restoring IAH compared with standard diabetes care, including other diabetes technologies.
Methods: Six electronic databases were searched for published and unpublished observational and randomised-control studies (RCTs) from inception to 29th of May 2024.
J Endocr Soc
November 2024
Neuroendocrine and Pituitary Tumor Clinical Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Purpose: To assess whether simultaneous normalization of late-night salivary cortisol (LNSC) and mean urinary free cortisol (mUFC) in patients with Cushing disease treated with osilodrostat is associated with better clinical outcomes than control of mUFC or LNSC alone.
Methods: Pooled data from two phase III osilodrostat studies (LINC 3 and LINC 4) were analyzed. Both comprised a 48-week core phase and an optional open-label extension.
Eye (Lond)
November 2024
School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Background: Convergence insufficiency (CI) is a common condition that can impair visual performance and comfort during close visual work. This observational study evaluated the effectiveness of interventions on clinical outcomes and health-related quality-of-life using the Adult Strabismus-20 (AS20) questionnaire in patients with CI.
Methods: Data was extracted from a database collected at first consultation from 2015 to 2022.
J Int AIDS Soc
December 2024
Sheffield Centre for Health and Related Research (SCHARR); School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Small
January 2025
School of Mechanical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.
Nanoplastics (NPs) pollution is a global issue posing potential threats to human health, particularly the digestive system. NPs may exacerbate intestinal inflammation, increasing the risk of inflammatory bowel disease. However, the impact of intestinal peristalsis on NP-induced inflammation remains unknown.
View Article and Find Full Text PDFJ Clin Epidemiol
February 2025
Institute for Research in Health, Environment and Work, University of Rennes, Rennes, France.
J Surg Educ
January 2025
Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, South Yorkshire, United Kingdom, S10 2TN; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, South Yorkshire, United Kingdom, S10 2JF.
Introduction: Evidence-based Medicine (EBM) is fundamental to modern healthcare and its integration into postgraduate curricula is strongly advocated. Despite its relevance, incorporating EBM in postgraduate training, specifically in general surgery, is fraught with challenges. This study aims to explore the perceptions of general surgical trainees regarding EBM, focusing on the process of achieving competency, assessment and its associated challenges.
View Article and Find Full Text PDFAm J Hum Genet
December 2024
Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany; Technical University of Munich (TUM) and Klinikum Rechts der Isar, TUM School of Medicine and Health, 81675 Munich, Germany. Electronic address: